Results 11 to 20 of about 12,430 (191)
Glia-to-glia serotonin signaling directs MMP-dependent infiltration for experience-dependent synapse pruning. [PDF]
PLoS BiologySynapse connectivity is optimized in response to environmental input in critical periods, characterized by experience-dependent, temporally-restricted, and transiently-reversible synapse pruning by glial phagocytes.
Vanessa Kay Miller, Kendal Broadie
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Frontiers in Neuroergonomics, 2022 Psilocybin (a serotonin 2A, or 5-HT2A, receptor agonist) has shown preliminary efficacy as a treatment for mood and substance use disorders. The current report utilized positron emission tomography (PET) with the selective 5-HT2A receptor inverse agonist
Frederick S. Barrett +9 more
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The antidepressant 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function. [PDF]
PLoS ONE, 2014 There is considerable interest in defining new agents or targets for antithrombotic purposes. The 5-HT2A receptor is a G-protein coupled receptor (GPCR) expressed on many cell types, and a known therapeutic target for many disease states.
Olivia A Lin +4 more
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PACAP–PAC1 Signaling Regulates Serotonin 2A Receptor Internalization
Frontiers in Endocrinology, 2021 Mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP) display psychomotor abnormalities, most of which are ameliorated by atypical antipsychotics with serotonin (5-HT) 2A receptor (5-HT2A) antagonism. Heterozygous Pacap mutant mice show
Atsuko Hayata-Takano +12 more
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The role of serotonin 5-HT2A receptors in memory and cognition [PDF]
Frontiers in Pharmacology, 2015 Serotonin 5-HT2A receptors (5-HT2ARs) are widely distributed in the central nervous system, especially in brain region essential for learning and cognition. In addition to endogenous 5-HT, several hallucinogens, antipsychotics, and antidepressants function by targeting 5-HT2ARs.
Gongliang eZhang +2 more
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Scientific Reports, 2021 Serotonin 5-HT2 receptors are expressed in many tissues and play important roles in biological processes. Although the 5-HT2A receptor is primarily known for its role in central nervous system, it is also expressed in peripheral tissues.
Bangning Yu +3 more
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Decreased density of serotonin 5-HT2A receptors in rheumatoid arthritis [PDF]
Annals of the Rheumatic Diseases, 2006 Animal studies have indicated that 5-HT2A receptors could play a role in arthritic diseases.To analyse the binding properties of 5-HT2A receptors in patients with rheumatoid arthritis.Using a radioactive binding assay, 43 patients with rheumatoid arthritis were compared with 49 sex and age matched controls for density and affinity (measured as Bmax and
A, Kling +3 more
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Renal Replacement Therapy, 2020 Chronic kidney diseases (CKD) are an economic burden and occur worldwide in all age groups, and the advancement of kidney disease at some point leads to deregulate or influence the function of other body organs and to find a specific target to halt the ...
Gagandeep Kaur, Pawan Krishan
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Serotonin 5-HT2A receptor activation blocks TNF-α mediated inflammation in vivo. [PDF]
PLoS ONE, 2013 Tumor necrosis factor alpha (TNF-α) plays a key role in inflammation, and its production and signaling contribute to many inflammatory related diseases.
Felix Nau +3 more
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Communications Biology, 2021 Lyu et al analysed metabolic network integrity in Drosophila melanogaster to assess the systemic effects of nutrient choice. By knocking out the serotonin receptor, 5-HT2A, they demonstrated that the effects of different macronutrients on the stability ...
Yang Lyu +2 more
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