Results 21 to 30 of about 12,430 (191)

Involvement of 5-HT2A receptor hyperfunction in the anxiety-like behavior induced by doxorubicin and cyclophosphamide combination treatment in rats

Journal of Pharmacological Sciences, 2018
We examined whether combination treatment with doxorubicin and cyclophosphamide, a traditional chemotherapy for breast cancer, induced anxiety-like behavior in rats.
Yuka Nakamura, Yoshihisa Kitamura, Yusuke Sumiyoshi, Nanami Naito, Shiho Kan, Soichiro Ushio, Ikuko Miyazaki, Masato Asanuma, Toshiaki Sendo   +8 more
doaj   +1 more source

Hallucinogens and Serotonin 5-HT2A Receptor-Mediated Signaling Pathways [PDF]

, 2017
The neuropsychological effects of naturally occurring psychoactive chemicals have been recognized for millennia. Hallucinogens, which include naturally occurring chemicals such as mescaline and psilocybin, as well as synthetic compounds, such as lysergic acid diethylamide (LSD), induce profound alterations of human consciousness, emotion, and cognition.
Juan F, López-Giménez, Javier, González-Maeso   +1 more
openaire   +2 more sources

Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex

Molecular Brain, 2020
The serotonin (5-HT) system is the target of multiple anxiolytics, including Buspirone, which is a partial agonist of the serotonin 1A receptor (5-HT1A). Similarly, ligands of the serotonin 2A receptor (5-HT2A) were shown to alter anxiety level.
Anes Ju, Beatriz Fernandez-Arroyo, Yifan Wu, Débora Jacky, Anna Beyeler   +4 more
doaj   +1 more source

Biophysical validation of serotonin 5-HT2A and 5-HT2C receptor interaction. [PDF]

PLoS ONE, 2018
The serotonin (5-HT) 5-HT2A receptor (5-HT2AR) and 5-HT2C receptor (5-HT2CR) in the central nervous system are implicated in a range of normal behaviors (e.g., appetite, sleep) and physiological functions (e.g., endocrine secretion) while dysfunctional 5-
Daniel E Felsing, Noelle C Anastasio, Joanna M Miszkiel, Scott R Gilbertson, John A Allen, Kathryn A Cunningham   +5 more
doaj   +1 more source

Altered Serotonin 2A (5-HT2A) Receptor Signaling Underlies Mild TBI-Elicited Deficits in Social Dominance

Frontiers in Pharmacology, 2022
Various forms of traumatic brain injury (TBI) are a leading cause of disability in the United States, with the generation of neuropsychiatric complications such as depression, anxiety, social dysfunction, and suicidality being common comorbidities ...
Sean M. Collins, Christopher J. O’Connell, Evan L. Reeder, Sophia V. Norman, Kainat Lungani, Poornima Gopalan, Gary A. Gudelsky, Gary A. Gudelsky, Matthew J. Robson, Matthew J. Robson   +9 more
doaj   +1 more source

Increased DOI-Induced Wet-Dog Shakes in Adrenocorticotropic Hormone–Treated Rats Are Not Affected by Chronic Imipramine Treatment: Possible Involvement of Enhanced 5-HT2A–Receptor Expression in the Frontal Cortex

Journal of Pharmacological Sciences, 2008
We examined the influence of imipramine, a traditional tricyclic antidepressant, on the binding to serotonin (5-HT)2receptors and levels of 5-HT2A–receptor mRNA in the frontal cortex of rats treated with adrenocorticotropic hormone (ACTH).
Yoshihisa Kitamura, Kazuhiko Shibata, Kozue Akiyama, Shizue Kimoto, Yoshika Fujitani, Kouhei Kitagawa, Hirotaka Kanzaki, Mamoru Ouchida, Kenji Shimizu, Hiromu Kawasaki, Toshiaki Sendo, Yutaka Gomita   +11 more
doaj   +1 more source

Serotonin 2A (5-HT2A) receptor affects cell–matrix adhesion and the formation and maintenance of stress fibers in HEK293 cells

Scientific Reports, 2020
5-HT2A, a G-protein coupled receptor, is widely expressed in the human body, including in the gastrointestinal tract, platelets and the nervous system. It mediates various functions, for e.g.
Joe Anand Kumar John Jayakumar, Mitradas. M. Panicker, Basudha Basu   +2 more
doaj   +1 more source

Antagonist Functional Selectivity: 5-HT2A Serotonin Receptor Antagonists Differentially Regulate 5-HT2A Receptor Protein Level In Vivo [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2011
Dysregulation of the 5-HT2A receptor is implicated in both the etiology and treatment of schizophrenia. Although the essential role of 5-HT2A receptors in atypical antipsychotic drug actions is widely accepted, the contribution of 5-HT2A down-regulation to their efficacy is not known.
Prem N, Yadav, Wesley K, Kroeze, Martilias S, Farrell, Bryan L, Roth   +3 more
openaire   +2 more sources

Insights into the regulation of 5-HT2A serotonin receptors by scaffolding proteins and kinases [PDF]

Neuropharmacology, 2008
5-HT(2A) serotonin receptors are essential molecular targets for the actions of LSD-like hallucinogens and atypical antipsychotic drugs. 5-HT(2A) serotonin receptors also mediate a variety of physiological processes in peripheral and central nervous systems including platelet aggregation, smooth muscle contraction, and the modulation of mood and ...
John A, Allen, Prem N, Yadav, Bryan L, Roth   +2 more
openaire   +2 more sources

Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors [PDF]

Neuropharmacology, 2011
The serotonin 5-HT(2A) receptor (5-HT(2A)R) and dopamine D(2) receptor (D(2)R) are high-affinity G protein-coupled receptor targets for two different classes of antipsychotic drugs used to treat schizophrenia. Interestingly, the antipsychotic effects are not based on the regulation of same signaling mediators since activation of the 5-HT(2A)R and of ...
Laura, Albizu, Terrell, Holloway, Javier, González-Maeso, Stuart C, Sealfon   +3 more
openaire   +2 more sources