Psilocybin sex-dependently reduces alcohol consumption in C57BL/6J mice
Frontiers in Pharmacology, 2023 The classical psychedelic psilocybin is of interest as a treatment for alcohol use disorder (AUD). This study investigated the effects of psilocybin on voluntary ethanol consumption in adult male and female C57BL/6J mice administered saline or psilocybin
Kenneth Alper +9 more
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A systematic review to assess the use of psilocybin in the treatment of headaches
European Psychiatry, 2023 Introduction Psilocybin is a naturally occurring psychedelic compound whose effects have been seen in studies for treatment of depression, anxiety and pain management.
S. Bhanot +4 more
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Inhibition of alpha oscillations through serotonin-2A receptor activation underlies the visual effects of ayahuasca in humans [PDF]
, 2016 Ayahuasca is an Amazonian psychotropic plant tea typically obtained from two plants, Banisteriopsis caapi and Psychotria viridis. It contains the psychedelic 5-HT2A and sigma-1 agonist N,N-dimethyltryptamine (DMT) plus ß-carboline alkaloids with ...
Alonso, Joan Francesc +12 more
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Psychedelics Promote Structural and Functional Neural Plasticity. [PDF]
, 2018 Atrophy of neurons in the prefrontal cortex (PFC) plays a key role in the pathophysiology of depression and related disorders. The ability to promote both structural and functional plasticity in the PFC has been hypothesized to underlie the fast ...
Barragan, Eden V +15 more
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Shannon entropy of brain functional complex networks under the influence of the psychedelic Ayahuasca [PDF]
, 2016 The entropic brain hypothesis holds that the key facts concerning psychedelics are partially explained in terms of increased entropy of the brain's functional connectivity.
de Araujo, Draulio B. +4 more
core +6 more sources
Psilocybin facilitates fear extinction in mice by promoting hippocampal neuroplasticity
Chinese Medical Journal, 2023 . Background:. Posttraumatic stress disorder (PTSD) and depression are highly comorbid. Psilocybin exerts substantial therapeutic effects on depression by promoting neuroplasticity.
Yingjie Du +7 more
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Self unbound: ego dissolution in psychedelic experience [PDF]
, 2017 Users of psychedelic drugs often report that their sense of being a self or ‘I’ distinct from the rest of the world has diminished or altogether dissolved.
Gerrans, Philip, Letheby, Chris
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The Effects of Daytime Psilocybin Administration on Sleep: Implications for Antidepressant Action
Frontiers in Pharmacology, 2020 Serotonergic agonist psilocybin is a psychedelic with antidepressant potential. Sleep may interact with psilocybin’s antidepressant properties like other antidepressant drugs via induction of neuroplasticity. The main aim of the study was to evaluate the
Daniela Dudysová +28 more
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Recreational use, analysis and toxicity of tryptamines [PDF]
, 2015 The definition New psychoactive substances (NPS) refers to emerging drugs whose chemical structures are similar to other psychoactive compounds but not identical, representing a "legal" alternative to internationally controlled drugs.
Mannocchi, Giulio +3 more
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Knocking on the Doors of Perception: the role of psilocybin in substance use disorder treatment
European Psychiatry, 2023 Introduction Substance use disorders(SUDs) are a major health concern and current treatment interventions have proven only limited success. Despite increasing effectiveness, still about 50–60% relapse within 6–12 months after treatment [Cornelius et al.,
R. Sousa +9 more
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