Results 11 to 20 of about 10,701 (213)

Psilocybin desynchronizes the human brain [PDF]

Nature
A single dose of psilocybin, a psychedelic that acutely causes distortions of space–time perception and ego dissolution, produces rapid and persistent therapeutic effects in human clinical trials1–4.
Metcalf, Nicholas V, Bender, David A, Scheidter, Kristen M, Perry, Demetrius, Fair, Damien A, Kay, Benjamin P, Gratton, Caterina, Horan, Christine, Whiting, Forrest I, Gordon, Evan M, Lenze, Eric J, Nicol, Ginger E, Padawer-Curry, Jonah A, Raichle, Marcus E, Subramanian, Subha, Schweiger, Julie A, Chen, Yong, Carhart-Harris, Robin, Reneau, T Rick, Krimmel, Samuel R, Laumann, Timothy O, Chacko, Ravi V, Shimony, Joshua S, Dosenbach, Nico UF, Shinohara, Russell T, Yacoub, Essa, Siegel, Joshua S, Moser, Julia, Vizioli, Luca, Wong, Dean F, et al,, Nelson, Steven M, Raison, Charles L, Snyder, Abraham Z   +33 more
core   +5 more sources

Heterologous production of psilocybin

, 2019
The invention discloses a recombinant host cell for producing psilocybin and related compounds, such as metabolic intermediates of the psilocybin biosynthesis.
Oksman-Caldentey, Kirsi-Marja; id_orcid, Rischer, Heiko; id_orcid, Rantasalo, Anssi, Mojzita, Dominik, Kuivanen, Joosu   +4 more
core   +6 more sources

ALSUntangled #77: Psilocybin

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
ALSUntangled reviews alternate and off-label treatments prompted by patient interest. Here, we review psilocybin, a chemical derived from mushrooms and belonging in the category of drugs known as psychedelics.
Carter, Gregory T, Crayle, Jesse, Greene, Maxwell, Pattee, Gary, Jackson, Carlayne, Sun, Yuyao, Bakshi, Bhavya, Brown, Andrew, Fullam, Timothy, Pierce, Kaitlyn, Wiedau, Martina, Armon, Carmel, Wicks, Paul, Ratner, Dylan, Mallon, Elise, Bromberg, Mark, Bowser, Robert, Yerraguntla, Sandeep, Barkhaus, Paul, Cadavid, Javier Mascias, Breevoort, Sarah, Wang, Olivia, Heiman-Patterson, Terry, Bedlack, Richard, Chang, Vincent, Bertorini, Tulio, Jhooty, Sartaj, Mcdermott, Christopher J   +27 more
core   +3 more sources

The Therapeutic Potential of Psilocybin [PDF]

Molecules, 2021
The psychedelic effects of some plants and fungi have been known and deliberately exploited by humans for thousands of years. Fungi, particularly mushrooms, are the principal source of naturally occurring psychedelics. The mushroom extract, psilocybin has historically been used as a psychedelic agent for religious and spiritual ceremonies, as well as a
Henry Lowe, Ngeh Toyang, Blair Steele, Henkel Valentine, Justin Grant, Amza Ali, Wilfred Ngwa, Lorenzo Gordon   +7 more
openaire   +3 more sources

Rapid quantification of Psilocybin with reversed-phase HPLC and single-wavelength detection [PDF]

, 2021
The alkaloid psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) and the neurologically active psilocin (4-hydroxy-N,N-dimethyltryptamine) are the foremost compounds of pharmaceutical interest in Psilocybe mushrooms.
Alexzander, Samuelsson, Eric, Janusson, Markus, Roggen, Sajni, Shah   +3 more
core   +1 more source

The Effects of Daytime Psilocybin Administration on Sleep: Implications for Antidepressant Action

Frontiers in Pharmacology, 2020
Serotonergic agonist psilocybin is a psychedelic with antidepressant potential. Sleep may interact with psilocybin’s antidepressant properties like other antidepressant drugs via induction of neuroplasticity. The main aim of the study was to evaluate the
Daniela Dudysová, Daniela Dudysová, Karolina Janků, Karolina Janků, Michal Šmotek, Michal Šmotek, Elizaveta Saifutdinova, Elizaveta Saifutdinova, Jana Kopřivová, Jana Kopřivová, Jitka Bušková, Jitka Bušková, Bryce Anthony Mander, Martin Brunovský, Martin Brunovský, Peter Zach, Jakub Korčák, Veronika Andrashko, Michaela Viktorinová, Michaela Viktorinová, Filip Tylš, Filip Tylš, Anna Bravermanová, Anna Bravermanová, Tom Froese, Tomáš Páleníček, Tomáš Páleníček, Jiří Horáček, Jiří Horáček   +28 more
doaj   +1 more source

Psilocybin facilitates fear extinction in mice by promoting hippocampal neuroplasticity

Chinese Medical Journal, 2023
. Background:. Posttraumatic stress disorder (PTSD) and depression are highly comorbid. Psilocybin exerts substantial therapeutic effects on depression by promoting neuroplasticity.
Yingjie Du, Yunfeng Li, Xiangting Zhao, Yishan Yao, Bin Wang, Liming Zhang, Guyan Wang, Jing Ni   +7 more
doaj   +1 more source

Electrical spiking of psilocybin fungi [PDF]

, 2022
Psilocybin fungi, aka “magic” mushrooms, are well known for inducing colorful and visionary states of mind. Such psychoactive properties and the ease of cultivating their basidiocarps within low-tech setups make psilocybin fungi promising pharmacological
Gandia, Antoni, Adamatzky, Andrew
core   +1 more source

A systematic review to assess the use of psilocybin in the treatment of headaches

European Psychiatry, 2023
Introduction Psilocybin is a naturally occurring psychedelic compound whose effects have been seen in studies for treatment of depression, anxiety and pain management.
S. Bhanot, M. C. Q. Lin, S. Bains, A. Monroe, V. W. L. Tsang   +4 more
doaj   +1 more source

Effectiveness of Psilocybin on Depression: A Qualitative Study

, 2021
Introduction: Psilocybin mushroom use is well documented in spiritual and religious ceremonies globally. This drug is now the most popular in Europe and the USA.
Erlam, G, Alshaikhli, H, Al-Naggar, RA
core   +1 more source