Results 41 to 50 of about 27,974 (178)

White matter hyperintensities are associated with locus coeruleus atrophy and astrocytic β2‐adrenergic receptor expression

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION White matter hyperintensities (WMHs) are a robust marker of brain aging and dementia risk, typically attributed to vascular pathology. However, impaired astrocytic support may also contribute. The locus coeruleus (LC), which degenerates early in aging and Alzheimer's disease, provides widespread noradrenergic projections that ...
Victor Vidal, Gonzalo Farías, Carolina Delgado, Paul H. Delano, Rodrigo C. Vergara, Patricia Orellana, Tomás Ossandón, Nicolás A. Crossley, Cecilia Gonzalez‐Campo, Sharon L. Naismith, Raul Gonzalez‐Gomez, Carlos Coronel‐Oliveros, Agustín Ibáñez, Gabriel Wainstein, Robert D. Sanders, James M. Shine, Vicente Medel   +16 more
wiley   +1 more source

Soticlestat as an adjunctive therapy in children and young adults with Dravet syndrome

Epilepsia, Volume 67, Issue 6, Page 2796-2807, June 2026.
Overview of the phase 3 trial evaluating soticlestat as adjunctive therapy in children and young adults with Dravet syndrome. Abstract Objective This study evaluated the efficacy, safety, and tolerability of soticlestat as adjunctive therapy in children and young adults with Dravet syndrome (DS).
Joseph Sullivan, Kette Valente, Vicente Villanueva, Adam Strzelczyk, Rima Nabbout, Eiji Nakagawa, Yuehua Zhang, Marta Zolnowska, Yasir Khan, Cheng Dong, Samuel Hsiao, Sarah I. Sheikh, Philipp von Rosenstiel, Mahnaz Asgharnejad, Venkatesha Murthy   +14 more
wiley   +1 more source

Literatura e psiquiatria [PDF]

Revista Latinoamericana de Psicopatologia Fundamental, 2010
Quando em 2005 foi criada, por iniciativa do Profes-sor George Christodoulou, a Secao “Literatura e Psiquiatria”da Associacao Mundial de Psiquiatria (WPA), durante aAssembleia Geral do Congresso realizado no Cairo no veraodesse ano, deu-se um passo importante dentro da empresaintelectual que pos em destaque a vinculacao entre a Medi-cina Mental e as ...
openaire   +3 more sources

Dissecting the polygenic architecture of psychopathology via singular value decomposition of eight psychiatric genome‐wide association studies and evaluation of component‐based polygenic scores

General Psychiatry, Volume 39, Issue 3, June 2026.
ABSTRACT Background Current research suggests that genetic risk for psychiatric disorders is largely due to distinct combinations of many common variants shared by different disorders. This points to the existence of latent components affecting different dimensions of psychopathology.
Fernando Facal, Ana M. Pérez‐Gutiérrez, Javier Costas   +2 more
wiley   +1 more source

Projeto de uma (psico)patologia do sujeito (I): Redefinição do conceito de psicopatologia à luz da questão do sujeito

Revista Latinoamericana de Psicopatologia Fundamental, 2020
Este trabalho propõe as bases teóricas para a elaboração de uma nova definição de Psicopatologia , concebendo-a como o estudo dos impasses mórbidos perturbando, ou mesmo impedindo, a realização de um sujeito singular no interior do laço social.
Mario Eduardo Costa Pereira
doaj   +1 more source

Acute‐Phase Interventions After Self‐Harm for Preventing Suicide and Recurrence: A Systematic Review and Meta‐Analysis

Acta Psychiatrica Scandinavica, Volume 153, Issue 6, Page 610-626, June 2026.
ABSTRACT Introduction Suicide risk is markedly elevated following presentation after self‐harm, yet the evidence base for interventions initiated in the immediate post‐presentation period has not been synthesized with specific attention to this high‐risk window. Clarifying which early interventions may reduce adverse outcomes is essential for informing
Guilherme Pimenta Roncete, Luis C. Farhat, Loren Beiram, Bianca Besteti Fernandes Damiano, Craig J. Bryan, Karina L. Ramirez, Euripedes Constantino Miguel, Rodolfo Furlan Damiano   +7 more
wiley   +1 more source

Amisulpride Augmentation for Clozapine-Refractory Positive Symptoms: Additional Benefit in Reducing Hypersialorrhea

Case Reports in Psychiatry, 2015
One-third to half of patients taking clozapine suffer from refractory symptoms despite adequate treatment. Among other adverse effects, clozapine-induced hypersalivation (CIH) occurs in approximately half of all patients.
Fabiani Bogorni, Frederico Fernandes Moreira, Eduardo Mylius Pimentel, Géder Evandro Motta Grohs, Alexandre Paim Diaz   +4 more
doaj   +1 more source

Psychiatric symptoms are present in most of the patients with idiopathic normal pressure hydrocephalus

Arquivos de Neuro-Psiquiatria, 2014
Normal pressure hydrocephalus (NPH) is characterized by gait disturbance, dementia and/or urinary incontinence associated with dilation of ventricular system with normal opening cerebrospinal fluid pressure.
Matheus F. Oliveira, João R. M. Oliveira, José M. Rotta, Fernando C. G. Pinto   +3 more
doaj   +1 more source

Religiosidade e psiquiatria

Publicações ABP documentos e vídeos = ABP Publications documents and videos, 2015
A religiosidade e a psiquiatria são assuntos que estão constantemente sendo debatidos. A religiosidade é um aspecto importante na vida de um paciente, já que o mesmo acredita que a fé pode salvá-lo de qualquer doença e isso pode auxiliar em qualquer tratamento.
Anahy Fagundes Dias Fonseca, Alexander Moreira de Almeida   +1 more
openaire   +1 more source

Psychometric Properties and Longitudinal Predictors of the Columbia Suicide Severity Rating Scale (C‐SSRS) in a Brazilian Community Cohort: A 15‐Year Follow‐Up Study

Suicide and Life-Threatening Behavior, Volume 56, Issue 3, June 2026.
ABSTRACT Introduction The Columbia Suicide Severity Rating Scale (C‐SSRS) is widely used for assessing suicidal thoughts and behaviors, yet evidence on the validity of its scoring outputs in community‐based samples from low‐ and middle‐income countries remains scarce. Methods Participants included 2076 young adults (mean age 23.45, 47% female) from the
Rodolfo Furlan Damiano, Craig J. Bryan, Pedro M. Pan, Luis A. Rohde, Euripedes Constantino Miguel, Giovanni Abrahão Salum, Maurício S. Hoffmann   +6 more
wiley   +1 more source