Results 61 to 70 of about 106,528 (297)

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Brodalumab: Seven-Year US Pharmacovigilance Report

Dermatology and Therapy
Introduction Brodalumab, a human interleukin-17 receptor A antagonist, is approved for treating adults with moderate-to-severe plaque psoriasis who qualify for systemic therapy or phototherapy and have experienced treatment failure or loss of response to
Mark G. Lebwohl, John Y. Koo, April W. Armstrong, Bruce E. Strober, Soo Han Yoon, Nicole N. Rawnsley, Earl L. Goehring Jr., Abby A. Jacobson   +7 more
doaj   +1 more source

Bimekizumab for the Treatment of Plaque Psoriasis With Involvement of Genitalia: A 16-Week Multicenter Real-World Experience—IL PSO (Italian Landscape Psoriasis)

Dermatology Practical & Conceptual
Introduction: Genital involvement is observed in approximately 60% of patients with psoriasis, presenting clinicians with formidable challenges in treatment.
Diego Orsini, Piergiorgio Malagoli, Anna Balato, Luca Bianchi, Pina Brianti, Dario Buononato, Martina Burlando, Giacomo Caldarola, Anna Campanati, Elena Campione, Carlo G. Carrera, Andrea Carugno, Francesco Cusano, Paolo Dapavo, Annunziata Dattola, Clara De Simone, Valentina Dini, Maria Esposito, Maria C. Fargnoli, Francesca M. Gaiani, Luigi Gargiulo, Paolo Gisondi, Alessandro Giunta, Luciano Ibba, Claudia Lasagni, Francesco Loconsole, Vincenzo Maione, Edoardo Mortato, Angelo V. Marzano, Martina Maurelli, Matteo Megna, Santo R. Mercuri, Alessandra Narcisi, Annamaria Offidani, Giovanni Paolino, Aurora Parodi, Giovanni Pellacani, Luca Potestio, Pietro Quaglino, Antonio G. Richetta, Francesca Romano, Paolo Sena, Marina Venturini, Chiara Assorgi, Antonio Costanzo   +44 more
doaj   +1 more source

Mucosal‐Associated Invariant T Cells in Rheumatic Diseases

Arthritis &Rheumatology, EarlyView.
Mucosal‐associated invariant T (MAIT) cells are innate‐like T cells defined by their semi‐invariant T cell receptor and restriction by the major histocompatibility complex class I–related molecule (MR1). These cells are primarily activated by microbial‐derived metabolites presented by MR1 or by cytokines.
Manon Lesturgie‐Talarek, Virginie Gonzalez, Lucie Beaudoin, Noémie Sénot, Corinne Miceli‐Richard, Yannick Allanore, Agnès Lehuen, Jerôme Avouac   +7 more
wiley   +1 more source

Brodalumab: 5-Year US Pharmacovigilance Report

Dermatology and Therapy
Introduction Brodalumab is a human interleukin-17 receptor A antagonist indicated for the treatment of moderate-to-severe plaque psoriasis in adult patients who are candidates for systemic therapy or phototherapy and have failed to respond or have lost ...
Mark G. Lebwohl, John Y. Koo, April W. Armstrong, Bruce E. Strober, George M. Martin, Nicole N. Rawnsley, Earl L. Goehring, Abby A. Jacobson   +7 more
doaj   +1 more source

Statin use and the risk of chronic kidney disease in patients with psoriasis: A nationwide cohort study in Taiwan.

PLoS ONE, 2020
BackgroundPsoriasis is associated with hyperlipidemia. Few studies have examined the association among psoriasis, hyperlipidemia, and chronic kidney disease (CKD).
Kwei-Lan Liu, Wen-Chien Tsai, Hung-Pin Tu, Chih-Hung Lee   +3 more
doaj   +1 more source

The Importance of an Interdisciplinary Approach in the Selective Treatment of Psoriasis and Psoriatic Arthritis

, 2023
Karlygash Кarina, Ayaulym Abenova
openalex   +2 more sources

Clinical Significance of Gut Microbiota Community Types for Long‐Term Response to Fecal Microbiota Transplantation in Patients With Psoriatic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Fecal microbiota transplantation (FMT) holds promises as a beneficial supplement to methotrexate in patients with psoriatic arthritis (PsA). We therefore investigated how gut bacterial signatures in patients and donor strain engraftment were associated with long‐term response to FMT.
Panpan Qin, Maja S. Kragsnaes, Dorte K. Holm, Hans Christian Horn, Anna Christine Nilsson, Jens Kjeldsen, Karsten Kristiansen, Torkell Ellingsen   +7 more
wiley   +1 more source

Transition From Psoriasis to Psoriatic Arthritis is Characterized by Distinct Alterations in Peripheral Blood Tc17, Th17, and CD4+ Effector Memory Cells

Arthritis &Rheumatology, EarlyView.
Objective Cellular mechanisms driving transition from psoriasis to psoriatic arthritis have remained largely elusive. Thus, we investigated changes within the peripheral blood T cell compartment associated with the transition phase. Methods In an observational study, 116 patients were examined and categorized into subgroups including psoriasis with at ...
Hanna Graßhoff, Sara Comdühr, Henry Nording, Jacob von Esebeck, Philine Letz, Miriam Prohaczka, Handan Gedik, Henner Zirpel, Elisabeth Spallek, Linh Ha‐Wissel, El‐Baraa Adjailia, Sabrina Arnold, Konstantinos Fourlakis, Sebastian Klapa, Ingo Eitel, Oliver J. Müller, Jens Y. Humrich, Gabriela Riemekasten, Diamant Thaçi, Peter Lamprecht   +19 more
wiley   +1 more source

Current Perspectives on Psoriasis and Its Therapeutic Approaches: A Comprehensive Review

Journal of Education, Health and Sport
Psoriasis is a chronic inflammatory skin disorder characterized by an accelerated keratinocyte cell cycle, leading to the formation of scaly plaques.
Daria Oleksy, Kamil Hermanowicz, Urszula Kaczmarska, Aleksandra Woźniak, Michał Jakub Cioch , Julia Nowak, Katarzyna Doman , Marcin Mycyk , Agnieszka Najdek, Dawid Komada   +9 more
doaj   +1 more source