Results 61 to 70 of about 494,085 (317)

Overview of the molecular determinants contributing to the expression of Psoriasis and Psoriatic Arthritis phenotypes

Journal of Cellular and Molecular Medicine, 2020
Psoriasis and psoriatic arthritis are multifactorial chronic disorders whose etiopathogenesis essentially derives from the alteration of several signalling pathways and the co‐occurrence of genetic, epigenetic and non‐genetic susceptibility factors that ...
V. Caputo, C. Strafella, Andrea Termine, A. Dattola, S. Mazzilli, C. Lanna, Terenzio Cosio, E. Campione, G. Novelli, E. Giardina, R. Cascella   +10 more
semanticscholar   +1 more source

The Dermatologist and psoriatic arthritis [PDF]

Journal of the European Academy of Dermatology and Venereology, 2018
Linked article: This is a commentary on E. Audureau et al., pp. 1950–1953 in this issue.
van de Kerkhof, P.C.M., van de Kerkhof, P.C.M.   +1 more
openaire   +4 more sources

Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance

Advanced Science, EarlyView.
Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai, Kefei Wu, Qi Lin, Zhenzhen Cao, Yankun Jia, Ping Zhu   +5 more
wiley   +1 more source

Secukinumab: a new treatment option for psoriatic arthritis [PDF]

, 2016
Introduction: Psoriatic arthritis (PsA) is an immune-mediated chronic inflammatory arthropathy associated with impaired physical function and reduced quality of life.
McInnes, Iain B., Mease, Philip
core   +1 more source

Association of Structural Entheseal Lesions With an Increased Risk of Progression From Psoriasis to Psoriatic Arthritis

Arthritis & Rheumatology, 2020
To test whether the presence of structural entheseal lesions in psoriasis patients influences the risk of progression to psoriatic arthritis (PsA).
D. Simon, K. Tascilar, A. Kleyer, S. Bayat, E. Kampylafka, M. Sokolova, Ana Zevkovic, A. Hueber, J. Rech, L. Schuster, K. Engel, M. Sticherling, G. Schett   +12 more
semanticscholar   +1 more source

Targeting eRNA‐Producing Super‐Enhancers Regulates TNFα Expression and Mitigates Chronic Inflammation in Mice and Patient‐Derived Immune Cells

Advanced Science, EarlyView.
Targeting eRNAs from TNFα‐associated super‐enhancers with ASOs effectively reduces TNFα expression and inflammatory responses in both mouse models and patient‐derived immune cells. The conserved nature of these regulatory regions between species highlights the potential of eRNA‐targeted approaches as a therapeutic strategy for chronic inflammatory ...
Minjeong Cho, Su Min Kim, Jiyeon Lee, Oh Chan Kwon, Wonjin Woo, Eunji Lee, Hyo Jin Park, Yeongun Lee, So Hee Dho, Tae‐Kyung Kim, Min‐Chan Park, Richard A. Flavell, Lark Kyun Kim   +12 more
wiley   +1 more source

Urinary proteomics can define distinct diagnostic inflammatory arthritis subgroups [PDF]

, 2017
Current diagnostic tests applied to inflammatory arthritis lack the necessary specificity to appropriately categorise patients. There is a need for novel approaches to classify patients with these conditions.
Gaya, Daniel, Hampson, Rosie, Latosinska, Agnieszka, McInnes, Iain, Mischak, Harald, Mullen, William, Paterson, Caron, Porter, Duncan, Schanstra, Joost, Siebert, Stefan   +9 more
core   +2 more sources

Efficacy and Safety of Guselkumab, an Interleukin‐23p19–Specific Monoclonal Antibody, Through One Year in Biologic‐Naive Patients With Psoriatic Arthritis

Arthritis & Rheumatology, 2020
Guselkumab, a human monoclonal antibody specific to interleukin‐23p19, demonstrated efficacy and safety versus placebo through week 24 of the phase III DISCOVER‐2 trial in biologic‐naive patients with psoriatic arthritis (PsA).
I. McInnes, P. Rahman, A. Gottlieb, E. Hsia, A. Kollmeier, S. Chakravarty, Xie L. Xu, R. A. Subramanian, P. Agarwal, S. Sheng, Yusang Jiang, Bei Zhou, Y. Zhuang, Désirée van, der Heijde, P. Mease   +15 more
semanticscholar   +1 more source

Seronegative spondyloarthropathies : a review : part I: classification and differential diagnosis [PDF]

, 1993
The seronegative spondyloarthropathies comprise a group of non-rheumatoid disorders with similar clinical, laboratory and genetic features. Recognition of new clinical features has supported the notion that they all form part of a clinical spectrum ...
Borg, Andrew A., Dawes, Peter T., Hothersall, T.E.   +2 more
core  

Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis [PDF]

, 2009
Objectives Th17 cells are an effector T-cell population that plays a role in chronic inflammatory conditions and is dependent on IL-23 for their survival and expansion. More recently, a genetic association was discovered between polymorphisms in the gene
De Keyser, Filip, De Vos, Martine, Elewaut, Dirk, Jacques, Peggy, Kruithof, Elli, Melis, Lode, Mielants, Herman, VANDOOREN, BERNARD, Verbruggen, August   +8 more
core   +1 more source