The varieties of the psychedelic experience: A preliminary study of the association between the reported subjective effects and the binding affinity profiles of substituted phenethylamines and tryptamines [PDF]
Classic psychedelics are substances of paramount cultural and neuroscientific importance. A distinctive feature of psychedelic drugs is the wide range of potential subjective effects they can elicit, known to be deeply influenced by the internal state of
Erowid, Earth +6 more
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Objectives: This study was aimed at understanding the attitudes and positions of key Australian organisational and political stakeholders towards using psychedelic agents in medically supervised environments to treat mental health conditions ...
Breanne E Kunstler +5 more
doaj +1 more source
Introduction: The current corona virus disease (COVID-19) pandemic has caused a serious global health crisis that has affected large parts of the public and private life worldwide, including the use of psychoactive substances.
Ricarda Evens +19 more
doaj +1 more source
From Trials to Clinics: Considerations for Implementing Psychedelic-Assisted Therapy Into Clinical Practice. [PDF]
Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
Kim J, Lochhead L, Weissman CR.
europepmc +2 more sources
Reaction of N,N-Dimethyltryptamine with Dichloromethane Under Common Experimental Conditions. [PDF]
A large number of clinically used drugs and experimental pharmaceuticals possess the N,N-dimethyltryptamine (DMT) structural core. Previous reports have described the reaction of this motif with dichloromethane (DCM), a common laboratory solvent used ...
Dunlap, Lee E, Olson, David E
core +3 more sources
IntroductionThere is substantial public interest in psychedelics as potential treatments for psychiatric conditions. However, most psychedelics are criminalized under federal law in the USA, so it is unclear whether use occurs with clinical support.
Kevin F. Boehnke +17 more
doaj +1 more source
REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics
This paper formulates the action of psychedelics by integrating the free-energy principle and entropic brain hypothesis. We call this formulation relaxed beliefs under psychedelics (REBUS) and the anarchic brain, founded on the principle that—via their ...
R. L. Carhart-Harris, Karl J. Friston
semanticscholar +1 more source
Psychedelics, Mystical Experience, and Therapeutic Efficacy: A Systematic Review
The mystical experience is a potential psychological mechanism to influence outcome in psychedelic therapy. It includes features such as oceanic boundlessness, ego dissolution, and universal interconnectedness, which have been closely linked to both ...
Kwonmok Ko +3 more
semanticscholar +1 more source
Psychedelic Cognition—The Unreached Frontier of Psychedelic Science
Psychedelic compounds hold the promise of changing the face of neuroscience and psychiatry as we know it. There have been numerous proposals to use them to treat a range of neuropsychiatric conditions such as depression, anxiety, addiction and PTSD; and trials to date have delivered positive results in favor of the novel therapeutics.
openaire +4 more sources
The Subjective Effects of Psychedelics Are Necessary for Their Enduring Therapeutic Effects.
Classic psychedelics produce altered states of consciousness that individuals often interpret as meaningful experiences. Across a number of human studies, when the participant-rated intensity of the overall drug effects are statistically controlled for ...
D. Yaden, R. Griffiths
semanticscholar +1 more source

