Results 51 to 60 of about 94,086 (305)

Psychiatric epidemiology: selected recent advances and future directions

Bulletin of the World Health Organization, 2000
Reviewed in this article are selected recent advances and future challenges for psychiatric epidemiology. Major advances in descriptive psychiatric epidemiology in recent years include the development of reliable and valid fully structured diagnostic ...
Ronald C. Kessler
doaj  

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

A step beyond the hygiene hypothesis—immune-mediated classes determined in a population-based study

BMC Medicine, 2019
Background Comorbidity patterns of childhood infections, atopic diseases, and adverse childhood experiences (ACE) are related to immune system programming conditions.
Vladeta Ajdacic-Gross, Margot Mutsch, Stephanie Rodgers, Anja Tesic, Mario Müller, Erich Seifritz, En-Young N. Wagner, Roland von Känel, Markus A. Landolt, Nina Steinemann, Viktor von Wyl, Enrique Castelao, Marie-Pierre F. Strippoli, Jennifer Glaus, Caroline Vandeleur, Pedro M. Marques-Vidal, Peter Vollenweider, Martin Preisig   +17 more
doaj   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Backtracing persistent biomarker shifts to the age of onset: A novel procedure applied to men’s and women’s white blood cell counts in post-traumatic stress disorder

Biomarkers in Neuropsychiatry, 2021
Background: Traumatic experiences tend to be preserved in altered biomarker profiles. These profiles can be traced back from cross-sectional data regarding the age of exposure. Consequently, the change across developmental stages, e.g.
Vladeta Ajdacic-Gross, Lena Ajdacic, Yanhua Xu, Mario Müller, Stephanie Rodgers, Christine Wyss, Sebastian Olbrich, Anna Buadze, Erich Seifritz, En-Young N. Wagner, Dragana Radovanovic, Viktor von Wyl, Nina Steinemann, Markus A. Landolt, Enrique Castelao, Marie-Pierre F. Strippoli, Mehdi M. Gholamrezaee, Jennifer Glaus, Caroline Vandeleur, Martin Preisig, Roland von Känel   +20 more
doaj   +1 more source

Utilization of psychiatric care and antidepressants among people with different severity of depression: a population-based cohort study in Stockholm, Sweden [PDF]

, 2018
Purpose To identify how severity of depression predicts future utilization of psychiatric care and antidepressants. Methods Data derived from a longitudinal population-based study in Stockholm, Sweden, include 10443 participants aged 20–64 years ...
Moller, J, Yip, BHK, Yuying Sun, Forsell, Y,, Samuel Y. S. Wong, Andreas Lundin, Lundin, A, Jette Möller, Yvonne Forsell, Benjamin H. K. Yip, Lundin, A,, Wong, SYS, Forsell, Y, Sun, Y   +13 more
core   +1 more source

Long‐Term Ambient Benzene Exposure and Brain Disorders Among Urban Adults: Effect Modification by Genetic Susceptibility and Potential Mediation by Plasma Proteins

Advanced Science, EarlyView.
Low‐level ambient benzene exposure is associated with increased risks of multiple brain disorders in urban adults. Genetic susceptibility modifies these associations, while plasma proteomics points to potential biological pathways linking benzene exposure to adverse brain health.
Jianhui Guo, Xia Zhong, Petros Koutrakis, Carolina L. Zilli Vieira, Feifei Si, Yaqi Wang, Xinyao Lian, Yi Fan, Zhaokun Wang, Shaodan Huang, Jing Li   +10 more
wiley   +1 more source

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

Astrocytic FDX1 Contributes to Copper Dyshomeostasis‐associated Synaptic Dysfunction in Depression and Is Modulated by Exercise

Advanced Science, EarlyView.
Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao, Rongji Hui, Zhibo Tang, Tao Feng, Zhihang Hu, Xiaoqing Zhang, Ping Jiang, Hui Zhao, Kwok‐Fai So, Tianyuan Luo, Yanzhou Chang, Lan Yan   +11 more
wiley   +1 more source

From statistics to deep learning: Using large language models in psychiatric research

International Journal of Methods in Psychiatric Research
Background Large Language Models (LLMs) hold promise in enhancing psychiatric research efficiency. However, concerns related to bias, computational demands, data privacy, and the reliability of LLM‐generated content pose challenges.
Yining Hua, Andrew Beam, Lori B. Chibnik, John Torous   +3 more
doaj   +1 more source