Results 161 to 170 of about 4,725,283 (256)

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Functional psychosurgery in psychiatry: indications and preoperative evaluation. A narrative review. [PDF]

Front Psychiatry
Moleón-Ruiz Á, Álvarez de Toledo P, Martín-Bejarano M, Bioque M, Torres Díaz CV.   +4 more
europepmc   +1 more source

Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis

Animal Research and One Health, EarlyView.
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang, Tianqi Jin, Zexin Chen, Ye Gong, Qimin Liu, Zifang Wu, Heran Cao, Yan Li, Yuyan Liu, Tianhao Yang, Zhihong Jiang, Wuzi Dong   +11 more
wiley   +1 more source

Sex Differences in Adult ADHD: A Multidimensional Multi-Informant Observational Study. [PDF]

J Clin Med
Magnesa A, Costagli E, Dominicis F, De Rosa U, Iriti A, Petrucci A, Rimoldi B, Medda P, Schiavi E, Brancati GE, Perugi G.   +10 more
europepmc   +1 more source

A Mouse Model of Depression‐Tumor Multimorbidity Reveals the Mechanism of Tumor Growth Accelerated by Depression

Animal Research and One Health, EarlyView.
Depression accelerates tumor growth by dysregulation of tumor immune microenvironment. (A) Modeling methods: Subcutaneous tumor models were established under chronic unpredictable mild stress conditions, including cold swimming, physical restraint, and food/water deprivation, leading to increased tumor growth.
Yakun Ren, Xinpei Wang, Wen Wang, Xingjiu Yang, Mengyuan Li, Jing Du, Ran Gao   +6 more
wiley   +1 more source

Anxiety-depression interaction and somatic symptoms in functional gastrointestinal disorders: a retrospective cross-sectional study from gastroenterology outpatient clinics. [PDF]

BMJ Open
Xiao S, Ran P, Li L, Deng T, Gou J, He Y, Jiang C, Liu S, Zhang L, Chen L, Kuang L, Yang M, Fu X.   +12 more
europepmc   +1 more source

Influence of Psychiatric Comorbidities on Postoperative Outcomes Following Pediatric Medial Patellofemoral Ligament Reconstruction

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To compare postoperative complications, rehabilitation outcomes, and health care utilization in children undergoing primary medial patellofemoral ligament reconstruction for patellofemoral instability with and without a pre‐existing mental illness. Methods The TriNetX U.S.
Haad A. Arif, Pearce Lane, Shamar T. Elliott, Amit Momaya, Kevin A. Williams   +4 more
wiley   +1 more source

Preoperative Risk Factors for Opioid Use Predict Self‐Reported Health and Function Up to 6 Months After Anterior Cruciate Ligament Reconstruction

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To identify risk factors that predict the need for rescue opioid use and patient‐reported outcomes following an opioid‐limiting postoperative analgesia protocol after anterior cruciate ligament reconstruction. Methods This prospective cohort study recruited 44 patients undergoing primary arthroscopic‐assisted anterior cruciate ligament ...
Eric V. Neufeld, William DeGouveia, Camille Pinpin, Matthew Zinner, Michael J. Sayegh, Michael J. Meade, Steven E. Rokito   +6 more
wiley   +1 more source

“Hands‐On” white matter anatomy: Using Air Anatomy gestures and tractography on simple brain sections to enhance teaching of white matter directions

Anatomical Sciences Education, EarlyView.
Abstract Teaching white matter (WM) anatomy to undergraduates is challenging. This is partly because WM fibers are oriented intricately and Klingler's dissection, the gold standard method used to demonstrate it, often requires time, advanced anatomical knowledge, and refined dissection skills.
Doris George Yohannan, Rohini Punja, Thomas Iype, Chandrasekharan Kesavadas, Bejoy Thomas, Kannanvilakom Govindapillai Umesan, Aswathy Maria Oommen, Usha Devi Keezhathil Bhargavi   +7 more
wiley   +1 more source

Atypical Cerebellar Responses are Associated with Altered Neural Habituation during Sensory Stimulation in Autism

Autism Research, EarlyView.
ABSTRACT Sensory processing atypicalities are highly prevalent in autistic youth; yet, the neural mechanisms underlying these differences are not well understood. While the cerebellum plays a key role in sensorimotor coordination and is structurally and functionally atypical in the autistic brain, it has been overlooked in research investigating ...
Melis E. Cakar, Kaitlin K. Cummings, Susan Y. Bookheimer, Mirella Dapretto, Shulamite A. Green   +4 more
wiley   +1 more source