Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
An investigation of factors associated with depression in older adults
As the population ages, there is a need for continued research into the etiology of geriatric depression and improved ways to detect individuals at risk for developing this disorder.
Mayhew, Katherine Mary
core +1 more source
Glymphatic Dysfunction Reflects Post‐Concussion Symptoms: Changes Within 1 Month and After 3 Months
ABSTRACT Objective Mild traumatic brain injury (mTBI) may alter glymphatic function; however, its progression and variability remain obscure. This study examined glymphatic function following mTBI within 1 month and after 3 months post‐injury to determine whether variations in glymphatic function are associated with post‐traumatic symptom severity ...
Eunkyung Kim +3 more
wiley +1 more source
Attention Deficit HyperactivityDisorder (ADHD): Survey Report [PDF]
In the spring of 2016, the New Hampshire Pediatric Improvement Partnership (NHPIP) conducted an online survey of NH pediatric and family practice clinicians to understand practice patterns, comfort level, and support needs relative to caring for ...
Daviss, W. Burl +6 more
core +1 more source
Predictors of course and outcome in hypochondriasis after cognitive-behavioral treatment [PDF]
Background. Predictors of treatment outcome were evaluated in a clinical sample suffering from hypochondriasis. Methods: The sample consisted of 96 patients with hypochondriacal disorder according to DSM-IV or high syndrome scores on the Illness Attitude
Fichter, Manfred M. +3 more
core +1 more source
Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani +8 more
wiley +1 more source
New tools to evaluate the violence risk [PDF]
Traditionally, mental health professionals are requested to provide their opinion regarding how danger are the mentally ill patients who come into contact with the judicial system.
Jorge Oscar Folino +1 more
doaj
Psychological evaluation of patients with benign musculoskeletal system tumors
Objectives: This study was designed to determine to what extent psychological status was affected by sociodemographic characteristics and by being informed about the diagnosis in patients with benign musculoskeletal tumors.\nMethods: The study included ...
Ebru Sinici +4 more
doaj
Common mental disorders and perinatal depressive symptoms: an integrative review [PDF]
Objective: to investigate occurrence and risk factors for common mental disorders and perinatal depressive symptoms. Methods: an integrative literature review using CINAHL, Embase, PubMed, PsycINFO, and LILACS, looking for studies conducted between 2014
Bruno Pereira da Silva +3 more
doaj +3 more sources
Medical students` health-related quality of life - a comparative study [PDF]
Background/Aim. Previous studies on medical students’ subjective perception of health and health-related quality of life (HRQoL) showed inconclusive results.
Latas Milan +5 more
doaj +1 more source

