Results 61 to 70 of about 576,375 (293)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACTObjectiveCerebrospinal fluid (CSF) orexin‐A has been suggested to be a biomarker of Alzheimer disease (AD). In both cognitively unimpaired healthy older adults and individuals with symptomatic AD, CSF orexin‐A is positively associated with CSF Aβ42, p‐tau181, and total tau (t‐tau) concentrations.
Ruijin Lu +13 more
wiley +1 more source
Frontiers in Psychiatry, 2019 Introduction: The relationship between perinatal depressive symptoms, harm avoidance (HA), and a history of major depressive disorder (MDD) was examined in a prospective cohort study.Methods: This study was conducted from May 1, 2011, to December 31 ...
Chika Kubota +16 more
doaj +1 more source
FGF14 GAA Intronic Expansion in Unsolved Adult‐Onset Ataxia in the Care4Rare Canada Consortium
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background and Objectives Spinocerebellar ataxias (SCA) represent a clinically and genetically heterogeneous group of progressive neurodegenerative diseases with prominent cerebellar atrophy. Recently, a novel pathogenic repeat expansion in intron 1 of FGF14 was identified, causing adult‐onset SCA (SCA27B). We aimed to determine the proportion
Alexanne Cuillerier +20 more
wiley +1 more source
Symptom Identification for Interpretable Detection of Multiple Mental Disorders [PDF]
arXiv, 2022 Mental disease detection (MDD) from social media has suffered from poor generalizability and interpretability, due to lack of symptom modeling. This paper introduces PsySym, the first annotated symptom identification corpus of multiple psychiatric disorders, to facilitate further research progress.
arxiv
Dynamics of Disagreement: Large-Scale Temporal Network Analysis Reveals Negative Interactions in Online Collaboration [PDF]
Scientific Reports (2016) 6:36333, 2016 Disagreement and conflict are a fact of social life and considerably affect our well-being and productivity. Such negative interactions are rarely explicitly declared and recorded and this makes them hard for scientists to study. We overcome this challenge by investigating the patterns in the timing and configuration of contributions to a large online ...
arxiv +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective People with multiple sclerosis (pwMS) may require a high level of daily assistance both for indoor and outdoor activities. Usually, relatives or friends provide daily support to MS patients who have lost personal autonomy. Several factors such as disability level and disease duration may affect the burden of care in caregivers of ...
Giuseppe Schirò +9 more
wiley +1 more source
From Genotype to Phenotype: polygenic prediction of complex human traits [PDF]
arXiv, 2021 Decoding the genome confers the capability to predict characteristics of the organism(phenotype) from DNA (genotype). We describe the present status and future prospects of genomic prediction of complex traits in humans. Some highly heritable complex phenotypes such as height and other quantitative traits can already be predicted with reasonable ...
arxiv
Development of a Disease Model for Predicting Postoperative Delirium Using Combined Blood Biomarkers
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Postoperative delirium, a common neurocognitive complication after surgery and anesthesia, requires early detection for potential intervention. Herein, we constructed a multidimensional postoperative delirium risk‐prediction model incorporating multiple demographic parameters and blood biomarkers to enhance prediction accuracy ...
Hengjun Wan +7 more
wiley +1 more source
Evaluation of the psychometric properties of a Semi- structured Hoarding Rating Scale-Interview (HRS-I) in a Clinical Sample [PDF]
فصلنامه ابن سینا, 2017 Background: A valid and reliable tool for independent clinical evaluation of hoarding disorder (HD) seems to be necessary. The purpose of this paper was to assess the psychometric properties of a semi-structured diagnostic interview of HD in a clinical ...
K khorramdel +3 more
doaj
Examining the validity and reliability of the Taita symptom checklist using Rasch analysis
Journal of the Formosan Medical Association, 2015 The Taita symptom checklist (TSCL) is a standardized self-rating psychiatric symptom scale for outpatients with mental illness in Taiwan. This study aimed to examine the validity and reliability of the TSCL using Rasch analysis.
Yun-Ling Chen +3 more
doaj +1 more source