Results 141 to 150 of about 1,116,021 (305)

Precision Diagnostics in Sports‐Related Traumatic Brain Injury: Pathophysiology, Biomarker Development and Emerging Technologies

open access: yesAdvanced Sensor Research, EarlyView.
Sports‐related traumatic brain injuries (TBIs) remain underdiagnosed, within amateur athletic cohorts. This review critically synthesises recent advancements in AI‐assisted neuroimaging, blood‐based biomarker profiling, wearable biosensing platforms for early detection, injury stratification, and longitudinal surveillance of TBIs.
Daniel Nicol   +3 more
wiley   +1 more source

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

open access: yesAdvanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian   +26 more
wiley   +1 more source

Time‐Dependent Therapeutic Effect of S‐Ketamine on PTSD Mediated by VTA‐OFC Dopaminergic Neurocircuit

open access: yesAdvanced Science, EarlyView.
This study reveals that early rather than late administration of S‐ketamine can ameliorate PTSD symptoms. This phenomenon is attributed to reversing the progressive inhibition of VTADA neurons and the function of VTADA‐OFC circuit following stress. Targeted stimulation of the OFC by TI‐NIBS to enhance DA release effectively extends the therapeutic time
Ye Wang   +20 more
wiley   +1 more source

Navigating Transition Metal‐Dependent Cell Death: Mechanisms, Crosstalk, and Future Directions

open access: yesAdvanced Science, EarlyView.
Transition metals trigger distinct regulated cell death pathways beyond traditional apoptosis. This review examines ferroptosis (iron‐catalyzed lipid peroxidation) and cuproptosis (copper‐induced mitochondrial proteotoxicity), while exploring hypothetical “cobaltosis” as a novel pathway.
Qinghang Song, Yuxuan Yang, Lina Yang
wiley   +1 more source

Psychedelic Psychiatry’s Brave New World

open access: yesCell, 2020
D. Nutt, D. Erritzoe, R. Carhart-Harris
semanticscholar   +1 more source

Cortico‐Striatal‐Midbrain Circuit Dysregulation Underlying MK‐801 Induced Impulsivity and the Ameliorative Effects of SEP

open access: yesAdvanced Science, EarlyView.
Impulsivity is a symptom across multiple psychiatric disorders, yet its neural basis remains elusive. This study shows that the NMDAR antagonist MK‐801 elevates dopamine release and disrupts neuronal selectivity in the nucleus accumbens, leading to impulsive behavior.
Xueru Wang   +6 more
wiley   +1 more source

The Lancet Psychiatry Commission on psychological treatments research in tomorrow's science.

open access: yesLancet psychiatry, 2018
E. Holmes   +11 more
semanticscholar   +1 more source

A Replicable and Generalizable Neuroimaging‐Based Indicator of Pain Sensitivity Across Individuals

open access: yesAdvanced Science, EarlyView.
Humans differ in their sensitivity to pain. With six large and diverse fMRI datasets (total N = 1046), this study finds that such individual differences in pain sensitivity can be tracked by fMRI responses to painful stimuli. A highly generalizable machine learning model is further built to predict pain sensitivity across all datasets and analgesic ...
Li‐Bo Zhang   +7 more
wiley   +1 more source

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