Results 91 to 100 of about 6,522,528 (286)

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

open access: yesAdvanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi   +13 more
wiley   +1 more source

18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis

open access: yesAdvanced Science, EarlyView.
Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan   +11 more
wiley   +1 more source

The applicability and efficacy of Micro-Video Psychological Training Camp in groups with mild to moderate symptoms of depression and anxiety: A prospective and randomized controlled trial protocol. [PDF]

open access: yesFront Psychiatry, 2022
Zhao W   +16 more
europepmc   +1 more source

Stable Diffusion Models Reveal a Persisting Human–AI Gap in Visual Creativity

open access: yesAdvanced Science, EarlyView.
This study examines visual creativity in humans and generative AI using the TCIA framework. Human artists outperform AI overall, yet structured human guidance substantially improves AI outputs and evaluations. Findings reveal that alignment with human creativity depends critically on contextual framing, highlighting both the promise and current ...
Silvia Rondini   +8 more
wiley   +1 more source

Believing in oneself : can psychological training overcome the effects of social exclusion? [PDF]

open access: yes
This paper examines whether psychological empowerment can mitigate mental constraints that impede efforts to overcome the effects of social exclusion. Using a randomized control trial, we study a training program specifically designed to reduce stigma ...
Ghosal, Sayantan   +4 more
core  

Chronic Disease Monitoring Using Advanced Compliant Materials for Bioelectronics

open access: yesAdvanced Electronic Materials, EarlyView.
Compliant bioelectronic systems enable continuous monitoring of chronic disease through soft, stretchable materials and tissue‐conformal designs that support stable electrophysiological, mechanical, and biochemical sensing. Integration of diverse sensing modalities with thoughtful material selection, device architectures, and advanced fabrication ...
Han Kim   +7 more
wiley   +1 more source

Estrategias psicológicas para una intervención en crisis : un caso en balonmano femenino [PDF]

open access: yes, 2006
This paper studies a psychological intervention conducted with a female goalkeeper of a national division handball team. Her performance decreased when a ball struck her face.
Abenza Cano, Lucía   +2 more
core   +2 more sources

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