Results 41 to 50 of about 742,571 (298)

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Intimate partner violence and physical health in England: Gender stratified analyses of a probability sample survey

Women's Health
Background: Gender differences in the associated health outcomes of different forms of intimate partner violence (IPV) are understudied. The long-term effects of IPV on specific physical health conditions are also under-researched in comparison to the ...
Ladan Hashemi, Anastasia Fadeeva, Nadia Khan, Sally McManus   +3 more
doaj   +1 more source

Typology of Psychological Violence in Maqashid Sharia Perspective

At-turas: Jurnal Studi Keislaman
Psychological violence in the household is a criminal offense that has not been explained with certainty. The PKDRT Law itself only explains the formulation of the consequences of psychological violence. Thus, it is important to create a typology of this
Iffaty Nasyiah, Risma Nur Arifah
doaj   +1 more source

Machine‐Learning Decomposition Identifies a Big Two Structure in Human Personality with Distinct Neurocognitive Profiles

Advanced Science, EarlyView.
Using machine learning on a mega‐scale global dataset (n = 1,336,840) reveals a robust personality trait architecture beyond the Big Five. A Big Two model, broadly capturing social engagement and internal mentation, defines a geometric space that links personality to neurocognitive profiles.
Kaixiang Zhuang, Ji Chen, Jinfeng Han, Wei Cheng, Jiang Qiu, Jianfeng Feng, Simon Eickhoff, Deniz Vatansever   +7 more
wiley   +1 more source

Occupational Violence and Staff Safety in Health-Care: A Cross-Sectional Study in a Large Public Hospital

Risk Management and Healthcare Policy, 2021
Zainab R Al-Shaban,1 Sultan T Al-Otaibi,2 Hatem A Alqahtani3 1Primary Healthcare Centers, Department of Occupational Medicine, Ministry of Health, Qatif, Kingdom of Saudi Arabia; 2Department of Public Health, College of Public Health, Imam Abdulrahman ...
Al-Shaban ZR, Al-Otaibi ST, Alqahtani HA
doaj  

Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

Advanced Science, EarlyView.
In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang, Nan Liang, Wenbo Li, Shuai Xu, Peng Li, Wanze Ni, Na Li, Sha Han, Ningjing Ou, Haowei Bai, Yuxiang Zhang, Furong Bai, Yifan Sun, Dewei Qian, Xinjie Bu, Erlei Zhi, Ruhui Tian, Yuhua Huang, Jingpeng Zhao, Fujun Zhao, Hao Chen, Zheng Li, Chencheng Yao   +22 more
wiley   +1 more source

“Witness” to violence? Psychological discourses of children in situations of domestic violence [PDF]

, 2013
This paper takes a critical discursive and feminist perspective on psychological accounts of children who experience domestic violence. Academic, popular and professional discourses around domestic violence (DV) tend to represent children and young ...
Callaghan, Jane, Sixsmith, Judith
core  

Hierarchical Summary Statistics Encoding Across Primary Visual and Posterior Parietal Cortices

Advanced Science, EarlyView.
This study shows that mouse V1 simultaneously encodes the ensemble mean and variance of motion, providing a robust summary‐statistic representation that persists despite single‐neuron variability. These signals propagate to PPC, where they are transformed into abstract category representations during decision making.
Young‐Beom Lee, Oliver James, Gaeun Jung, Doyun Lee, Yee‐Joon Kim   +4 more
wiley   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

Mediating role of future fear of violence between the direct violence and witnessed violence and psychological capital: a study of doctors and nurses

BMC Health Services Research
Background Healthcare professionals, particulary doctors and nurses, experience a complex relationship between direct violence and witnessed violence in the workplace. This study investigates how direct and witnessed violence affect psychological capital
Orhan Çakır, İrfan Akkoç, Korhan Arun, Ebru Dığrak, Seher Akkoç, Hasibe Serap Uluırmak Ünlüeroğlugil, Çağrı Işıl Çakır   +6 more
doaj   +1 more source