Results 41 to 50 of about 100,669 (252)

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

Mediating role of future fear of violence between the direct violence and witnessed violence and psychological capital: a study of doctors and nurses

BMC Health Services Research
Background Healthcare professionals, particulary doctors and nurses, experience a complex relationship between direct violence and witnessed violence in the workplace. This study investigates how direct and witnessed violence affect psychological capital
Orhan Çakır, İrfan Akkoç, Korhan Arun, Ebru Dığrak, Seher Akkoç, Hasibe Serap Uluırmak Ünlüeroğlugil, Çağrı Işıl Çakır   +6 more
doaj   +1 more source

Correlates of Intimate Partner Violence in Ghana

SAGE Open, 2017
This study bridges a knowledge gap in existing literature by investigating correlates of male perpetrated intimate partner violence in Ghana. Based on a review of literature, it was hypothesized that some sociodemographic factors would be associated with
Paul Alhassan Issahaku
doaj   +1 more source

Psychological Violence in the dating relationship in university students starting the Psychology career. A qualitative study

Revista de Psicología, 2021
Introduction. The alarming increase in dating violence produces devastating psychological and behavioral consequences. Objective: To understand, from a qualitative perspective, the characteristics of psychological violence (PV) in the dating relationship,
María de los Ángeles Páramo, Flavia Susana Arrigoni, Aldana Romina Ligorria Diaz   +2 more
doaj   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Experience‐Dependent Reorganization of Hippocampal CA3 Neuronal Ensembles Associates With Memory Generalization

Advanced Science, EarlyView.
Mice can transfer the learned rule of spatial working memory to guide similar but novel tasks. Hippocampal CA3 populational activity dynamically reorganize during memory generalization, shifting from task‐specific to generalized coding over testing days. Sparse yet redundant neural representations of CA3 enable rule transfer and cognitive map formation,
Da Song, Zilu Zhu, Yujun Deng, Yujie Song, Hui Li, Junjun Ni, Zhenzhen Quan, Yan Yan, Hong Qing   +8 more
wiley   +1 more source

PHYSICAL, SEXUAL AND PSYCHOLOGICAL VIOLENCE ACCORDING TO RODGERS’ EVOLUTIONARY CONCEPTUAL ANALYSIS

Cogitare Enfermagem, 2022
Objective: to clarify the concepts of physical, psychological, and sexual violence and, from the results obtained, to compare similarities and differences among concepts, their characteristics, conditions for events, and possible outcomes.
Victoria Grassi Bonamigo, Fernanda Broering Gomes Torres, Rafaela Gessner Lourenço, Marcia Regina Cubas   +3 more
doaj   +1 more source

Dual Lineages of Langerhans Cells Cooperate to Restore the Immune Barrier after Skin Injury

Advanced Science, EarlyView.
After skin injury, the epidermal immune barrier is rebuilt by two sources of Langerhans cells. Resident Langerhans cells first move into the wound during re‐epithelialization, guided by CXCR2 signaling. Later, recruited monocytes become long‐lived Langerhans cells.
Axel D. Schmitter‐Sánchez, Nicholas Basista, Sudhanshu Mishra, Hyeri Kim, Audrey Bench, Catherine Matte‐Martone, Min‐Soo Seo, Gun Woo Lee, Sangbum Park   +8 more
wiley   +1 more source

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Advanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan, Peiyi Li, Yufeng Chen, Zishan Dong, Yuanyuan Li, Boyu Liu, Yan Tai, Chuan Wang, Jianqiao Fang, Chengyu Yin, Boyi Liu   +10 more
wiley   +1 more source

Psychological Violence at Work: Problems in Applying the Law in Lithuania

Baltic Journal of Law & Politics
The recent Lithuanian Law of Labor Code of 28 July 20221 introduced into Lithuanian Labor Code the concept of “psychological violence.” The definitions of psychological violence under this law adopt quite a broad conception of the notion of psychological
Leščinskaitė Aistė
doaj   +1 more source