Results 131 to 140 of about 451,997 (312)
Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis
Advanced Science, EarlyView.Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang +16 more
wiley +1 more source
A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia
Advanced Science, EarlyView.A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun +11 more
wiley +1 more source
Advanced Science, EarlyView.Geometry and connectivity are complementary structures, which have demonstrated their ability to represent the brain's functional activity. This study evaluates geometric and connectome eigenmodes as biologically informed constraints for EEG source localization.
Pok Him Siu +6 more
wiley +1 more source
The Role Of Artificial Intelligence (ai) In The Mental Preparation Of High-level Athletes
مجلة العلوم و التكنولوجية للنشاطات البدنية و الرياضيةThe Object of the study aims to identify the role and importance of artificial intelligence the mental preparation of high-level athletes. For this purpose, we used the method a descriptive and analytical approach, which is based on theoretical readings
Benyoucef HAFSAOUI
doaj +1 more source
Leader values as predictors of employee affect and work passion intentions [PDF]
, 2012 The purpose of this study was to examine the empirical connection between employee perceptions of their leaders’ values orientation, employee job-specific affect, and the resultant impact these two constructs have on employee work passion intentions ...
Roberts, Lyn, Zigarmi, Drea
core
Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management
Advanced Science, EarlyView.ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak +9 more
wiley +1 more source
Toward a Theory of Learner-Centered Training Design: An Integrative Framework of Active Learning [PDF]
, 2009 [Excerpt] The goal of this chapter, therefore, is to develop an integrative conceptual framework of active learning, and we do this by focusing on three primary issues.
Bell, Bradford S, Kozlowski, Steve W. J.
core +1 more source
Advanced Science, EarlyView.The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi +13 more
wiley +1 more source
Advanced Science, EarlyView.A bioactive hydrogel incorporating Chlorella vulgaris and paeoniflorin within a carboxymethyl chitosan/sodium alginate matrix cross‐linked with genipin is developed for inflammatory bowel disease therapy. The hydrogel exhibits gastric stability and intestine‐responsive release.
Jing Lu +8 more
wiley +1 more source
The response to Binet production on Brazilian education: untold aspects of a history
Revista Brasileira de História da Educação, 2014 The acceptance of Binet’s psychometric work in Brazilian education in the first decades of the 20th century is discussed, focusing on authors who produced a critical view of the use of IQ tests, or experienced a tension with authorities when ...
Regina Helena de Freitas Campos +2 more
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