Results 111 to 120 of about 407,345 (247)

Mapping the landscape of psychological literature on threat from 1961 to 2023 through structural topic modeling. [PDF]

PLoS One
Ouyang H, Wan C, Fischer R.
europepmc   +1 more source

Astrocytic FDX1 Contributes to Copper Dyshomeostasis‐associated Synaptic Dysfunction in Depression and Is Modulated by Exercise

Advanced Science, EarlyView.
Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao, Rongji Hui, Zhibo Tang, Tao Feng, Zhihang Hu, Xiaoqing Zhang, Ping Jiang, Hui Zhao, Kwok‐Fai So, Tianyuan Luo, Yanzhou Chang, Lan Yan   +11 more
wiley   +1 more source

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source

The Economic Utility of Clinical Psychology in the Multidisciplinary Management of Pain

Frontiers in Psychology, 2017
Emanuele M. Giusti, Emanuele M. Giusti, Giada Pietrabissa, Giada Pietrabissa, Gian Mauro Manzoni, Gian Mauro Manzoni, Roberto Cattivelli, Roberto Cattivelli, Enrico Molinari, Enrico Molinari, Hester R. Trompetter, Karlein M. G. Schreurs, Gianluca Castelnuovo, Gianluca Castelnuovo   +13 more
doaj   +1 more source

A next generation of the schema therapy model of personality pathology: A cross-cultural and international study protocol. [PDF]

PLoS One
Mamali FC, Rijkeboer M, Molenaar D, Rameckers SA, Panzeri M, Arntz A, Lee CW, Brockman R, Ho Tan D, Mozumder MK, Gayen TK, Dyakov D, Stabrouskaya Y, Gatam A, Lobanovich V, Kanavina S, Romanovich V, Andreevich OA, Tkhoryk N, Shabaikovich A, Dierckx E, Pauwels E, Eggermont K, Matos FR, Puléo Barela R, Frossard LQ, Lazarova IS, Peneva K, Katrandjieva A, St Lazarova A, Zhu Y, Lyu B, Liu Y, Li L, Qin H, Guo X, Hu X, Zhang S, Ma OYT, Tang ALY, Moeller SB, Arendt ITP, Bach B, Meline J, Tapia G, M'bailara K, Abdushelishvili K, Begiashvili A, Badrishvili N, Gvinianidze A, Akopashvili L, Khabazi I, Kopf-Beck J, Leithne C, Renner F, Egli S, Quaatz SM, Malogiannis IA, Giannoulis E, Simos G, Unoka Z, Simon L, Simon V, Munivenkatappa M, Sudhir PM, Kohli TK, Shrivastava A, Misra AA, Khanna A, Louis JP, Santoso NM, Shanti TI, Witarso LS, Hedayati M, Samimi A, Malekasgar S, Basile B, Krone I, Orupe A, Gecaite-Stonciene J, Pociunaite J, Renee Tan HJ, Chan E, Heimkumar V, Kadri N, Karroumi S, Chentaf FZ, Ezzahiri N, Rachidi H, Bouchebti S, Bouidar H, Hikmat W, Chroukate F, Ennaciri Z, Thimm JC, Lorentzen V, Michałowski JM, Popiel AE, Mącik D, Browarczyk WM, Céu Salvador MD, Păduraru AE, Semeniuc SE, Stroian PI, Șubredu I, Yaltonskaya A, Maryasova D, Titova O, Gegel N, Gorodentseva N, Skryabina M, Plichko A, Pavlova O, Prokaeva S, Malashchanka V, Michelle Neo HL, Stein DJ, Hawa W, Hartmann JP, Lee E, Song Y, Gómez-Juanes R, Calvete E, Cid J, Schmidt RE, Homan S, Sakulsriprasert C, Phukao D, Thawornwutichat R, Mamoon W, Chandraungs A, Supreeyaporn N, Bachrach N, Keulen-de Vos M, Lobbestael J, Dorrestijn E, Krans J, Yakin D, Baştak D, Taşlioğlu Sayiner AC, İnce B, Tasilaridis S, Ergelen M, Kennedy FC, Taylor CDJ, First MB, Lockwood G, Appenzeller Z, Norton AR, Seeley-Wait E, Abbott MJ, Allen KL, Hasan S, Morales Hernández SA, Sharaf AM, Ruths FA.   +155 more
europepmc   +1 more source

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Editorial: Advances in generative artificial intelligence for mental health. [PDF]

Front Digit Health
Han N, Guan Z, Li A, Liu X, Liu X, Xue J.   +5 more
europepmc   +1 more source

Paternal Sperm Gnas‐ICR Epigenetic Programming Contributes to PPP‐Like Phenotypes in Female Offspring

Advanced Science, EarlyView.
A paternal glucocorticoid–sperm Gnas‐ICR axis is linked to ovarian endocrine programming in female offspring. Paternal preconception caffeine exposure elevates corticosterone, promotes sperm Gnas‐ICR hypermethylation, and is associated with ovarian Gnas upregulation, cAMP/PKA/CREB–StAR activation, enhanced estradiol synthesis, and PPP‐like phenotypes ...
Jing Huang, Lu Chen, Tiancheng Wu, Yating Li, Hui Wang   +4 more
wiley   +1 more source

Supporting patients using a digital self-management intervention for symptoms of fatigue, pain, and urgency/incontinence in Inflammatory Bowel Disease: a mixed methods process evaluation of trial facilitators. [PDF]

PLoS One
Wileman V, Czuber-Dochan W, Moss-Morris R, Dibley L, McGuinness S, Miller L, Norton C, Taylor SJC.   +7 more
europepmc   +1 more source