Results 141 to 150 of about 8,790,753 (253)

Patient iPSC‐derived astrocytes reveal impaired homeostasis and reactive‐like features in propionic acidemia

The Journal of Pathology, EarlyView.
Abstract Propionic acidemia (PA) is a neurometabolic disorder caused by propionyl‐CoA carboxylase deficiency with frequent neurological involvement, yet cell‐type‐specific mechanisms remain poorly defined. We established human induced pluripotent stem cell (iPSC)‐derived astrocytes (iAs) from patients harboring PCCA or PCCB mutations and investigated ...
Irene González‐Garnacho, Mar Álvarez, Francisco Zafra, Pilar Rodríguez‐Pombo, Lourdes R Desviat, Eva Richard   +5 more
wiley   +1 more source

Co‐Design to Capacity: An Instructional Design Approach for Indigenous Women Empowerment and Sustainable Technology Adoption

Sustainable Development, EarlyView.
ABSTRACT The adoption of rural livelihood technologies is often hindered by a gap between participatory design and user capacity. This study addresses this challenge with a co‐designed lemongrass distillation system in rural India that remained unused due to a lack of community capacity, despite a successful design process.
Aroun Clément Baudouin‐van Os, Raji Pushpalatha, Sruthy Sheela, Renjith Mohan, Maneesha Vinodini Ramesh   +4 more
wiley   +1 more source

Cardiorespiratory instability during sleep in infants: Physiological and developmental consequences

Sleep Research, EarlyView.
Abstract During fetal life, autonomic control of the cardio‐respiratory system undergoes rapid maturation and this continues after birth during the first year of life. This underlying immaturity of cardio‐respiratory control leads to an increased risk of cardio‐respiratory instabilities and resultant hypoxaemia during infancy.
Rosemary S. C. Horne
wiley   +1 more source

Epidemiological distribution of MRI‐based presumptive imaging diagnoses in a large general population of cats with suspected epileptic seizures

Veterinary Record, EarlyView.
Abstract Background The reported prevalence of feline idiopathic epilepsy (IE) and presumptive imaging diagnoses based on magnetic resonance imaging (MRI) varies depending on factors such as differences between primary care versus referral study populations.
Anna Knebel, Sebastian Meller, Julien Labruyère, Holger A. Volk   +3 more
wiley   +1 more source

A Scalable Model for Global Procedural Skills Training: Introduction to SELF

World Journal of Surgery, EarlyView.
Around the world, demand for surgical care is growing rapidly as populations expand and incomes rise. Procedural skills are still largely taught through apprenticeship models that depend on the availability of experienced instructors and specialized training environments. ABSTRACT Background Around the world, demand for surgical care is growing rapidly
Catherine J. Mohr, Megan Kern, Mitchell Corwin, Patrick Diamond, Eric O'Flynn   +4 more
wiley   +1 more source

Where to Begin? Prioritizing Procedures for Surgical Skills Training Development: SELF Series Article 2

World Journal of Surgery, EarlyView.
Scaling the global surgical care workforce through independent procedural skills training is essential to address unmet surgical need. Prioritization of a sub‐set of surgical skills is required. During the 2023 Surgical Education Learners Forum (SELF) Symposium, participants developed criteria to prioritize the development of self‐directed and ...
Amelia Levi, David R. Jeffcoach, Nobhojit Roy, Juan Carlos Puyana, Eric O'Flynn, Abebe Bekele   +5 more
wiley   +1 more source

Scaling SELF Simulation Training: SELF Series Article 5

World Journal of Surgery, EarlyView.
The shortage of practitioners trained to provide essential surgical care remains among the most stubborn contributors to the global burden of disease, particularly in resource‐constrained settings where expert trainers are scarce. The Surgical Education Learners Forum (SELF) is a global community of practice developing cost‐effective, scalable, open ...
Vanessa Moll, Deborah M. Rooney, May Liu, Dimitrios Stefanidis, Chisom R. Udeigwe‐Okeke, Mehdi Baqri, Marisa Seepersaud, Emmanuel A. Ameh, Olubunmi Fariyike, Doruk Ozgediz, Amit Maurya, Joshua Hantke, Selam Degu, Oliver Wylie, Eric O'Flynn   +14 more
wiley   +1 more source

Best Practices for Designing Effective Procedural Skills Training in Resource‐Constrained Settings: SELF Series Article 3

World Journal of Surgery, EarlyView.
Scaling the global surgical care workforce through independent procedural skills training is essential to address unmet surgical need. For self‐assessed simulation modules to be effective, developers need guidance and tools. This third article in the SELF series presents the expert recommendations of 2023 SELF Symposium participants on designing ...
Peter Weinstock, Kara L. Neil, Wenmiao Shu, Advait Gandhe, Vikas Karade, Eric O'Flynn, Emilio Velis, Robert Ssekitoleko, Natnael Shimelash, Christopher W. Reynolds   +9 more
wiley   +1 more source

Self‐Administered Skills Assessment Using Simulation Modules for Procedural Competency: SELF Series Article 4

World Journal of Surgery, EarlyView.
The shortage of practitioners trained to provide essential surgical care remains among the most stubborn contributors to the global burden of disease, particularly in resource‐constrained settings where expert trainers are scarce. The Surgical Education Learners Forum (SELF) is a global community of practice working to develop cost‐effective, scalable,
JoAnna L. Hunter‐Squires, Habila Umaru, Jacqueline Yao, Michelle N. Joseph, Eric O'Flynn   +4 more
wiley   +1 more source

What Happens After Menopause (WHAM)? A Progress Report of a Prospective Controlled Study of Women After Pre‐Menopausal Risk‐Reducing Bilateral Salpingo‐Oophorectomy

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Surgical menopause, the removal of both ovaries prior to natural menopause, may impact short‐and long‐term physical and emotional health. An increasingly common cause of surgical menopause is risk‐reducing salpingo‐oophorectomy (RRSO) in those at high inherited risk of ovarian cancer.
Sarah A. L. Price, Pauline M. Maki, Samar R. El Khoudary, Alison Brand, Rakibul M. Islam, Susan M. Domchek, Hadine Joffe, Gita D. Mishra, Katrina M. Moss, Fiona C. Baker, Sabine Braat, John D. Wark, Martha Hickey   +12 more
wiley   +1 more source