Results 191 to 200 of about 397,654 (297)

Allele‐Specific Regulation of PAXIP1‐AS1 by SMC3/CEBPB at rs112651172 in Psychiatric Disorders Drives Synaptic and Behavioral Dysfunctions in Mice

Advanced Science, EarlyView.
This study identifies a functional noncoding variant, rs112651172 (C/G), that drives allele‐specific expression of PAXIP1‐AS1 in monozygotic twin pairs discordant for schizophrenia and bipolar disorder. The risk G allele enhances CEBPB binding, leading to lncRNA upregulation, CNTNAP3 derepression, and synaptic and behavioral deficits in mice.
Chaoying Ni, He Chen, Qiaqi Chen, Yangyang Liao, Yunqian Wang, Linyan Ye, Xiaohui Wu, Hongyu Ni, Tingyun Jiang, Shufen Li, Qiong Yang, Hong Xue, Zhongju Wang, Feng Yi, Cunyou Zhao   +14 more
wiley   +1 more source

Predicting epigenetic aging by the transdiagnostic internalizing spectrum vs. depressive and anxiety syndromes. [PDF]

World Psychiatry
Freilich CD, Mann FD, Markon KE, Cole SW, Krueger RF.   +4 more
europepmc   +1 more source

Exploration of Novel Biomarkers Through a Precision Medicine Approach Using Multi‐Omics and Brain Organoids in Patients With Atypical Depression and Psychotic Symptoms

Advanced Science, EarlyView.
This study examines major depressive disorder with atypical features and psychotic symptoms through a multi‐omics precision medicine approach. By integrating clinical assessments, WBC scRNA‐seq, plasma proteomics, and brain organoid models, it uncovers immune dysregulation, synaptic protein alterations, and stress‐sensitive neuronal changes.
Insook Ahn, Soyeon Chang, Jiyoung Lee, Seok‐Ho Choi, Jinju Han, Yangsik Kim   +5 more
wiley   +1 more source

Suicide risk, psychopathology and cognitive impairments in schizophrenia with insomnia: a large-scale cross-sectional study. [PDF]

BMC Psychiatry
Lu C, Qi D, Ping Y, Zhang C, Wang S, Liu N, Wang X, Li S, Li J.   +8 more
europepmc   +1 more source

Transdiagnostic dimensions of psychopathology at first episode psychosis: findings from the multinational EU-GEI study [PDF]

, 2018
Diego Quattrone, Marta Di Forti, Charlotte Gayer‐Anderson, Laura Ferraro, Hannah E. Jongsma, Giada Tripoli, Caterina La Cascia, Daniele La Barbera, Ilaria Tarricone, Domenico Berardi, Andreı̈ Szöke, Celso Arango, Antonio Lasalvia, Andrea Tortelli, Pierre‐Michel Llorca, Lieuwe de Haan, Eva Velthorst, Julio Bobes, Miquel Bernardo, Julio Sanjuán, José Luis Santos, Manuel Arrojo, Cristina Marta Del‐Ben, Paulo Rossi Menezes, Jean‐Paul Selten, Peter B. Jones, James B. Kirkbride, Alexander Richards, Michael O’Donovan, Pak C. Sham, Evangelos Vassos, Bart P. F. Rutten, Jim van Os, Craig Morgan, Cathryn M. Lewis, Robin Murray, Ulrich Reininghaus   +36 more
openalex   +1 more source

LncRNA THUMPD3‐AS1 Regulates Behavioral and Synaptic Structural Abnormalities in Schizophrenia via miR‐485‐5p and ARHGAP8

Advanced Science, EarlyView.
Schizophrenia (SCZ) is linked to synaptic structural deficits driven by dysregulated noncoding RNAs. Using the novel ceRNAxis pipeline, THUMPD3‐AS1/miR‐485‐5p/ARHGAP8 is identified as a key regulator of actin cytoskeletal remodeling through noncanonical RhoB/C‐ROCK2 signaling. Modulating this axis ameliorates SCZ‐like phenotypes in mice and aligns with
Xiaojuan Gong, Lingxi Chen, Xin Guo, Anna Jiang, Yayi He, Chunxia Yan, Liang Ma, Jiayang Gao, Jinyu Zhang, Bao Zhang   +9 more
wiley   +1 more source

Association between specific childhood trauma and symptom dimensions in patients with obsessive-compulsive disorder: dimensional and network perspectives. [PDF]

Eur J Psychotraumatol
Huang B, Wu C, Cao H, Bi Z, Song G, Cheng J, Gao J, Wang Y, Li D, Zhao Q, Wang Z.   +10 more
europepmc   +1 more source

An Effective Oral Drug Delivery Route for Pharmacokinetic Complications: Spirulina Lipid Nanotechnology System

Advanced Science, EarlyView.
Spirulina‐nano system facilitates the formation of drug coating on spirulina's surface through electrostatic adsorption. It targets intestinal villi effectively and overcomes the pharmacokinetic complications of IBS‐D. This system successfully carried out the treatment of multiple symptoms, including diarrhea, visceral hypersensitivity, mental symptoms,
Jiahui Ye, Xinyi Wu, Jin Liu, Yongmi Guo, Chong Ji, Zhouyue Wang, Di Yang, Min Zhou   +7 more
wiley   +1 more source

Mapping Multimodal Risk Factors to Mental Health Outcomes. [PDF]

Nat Ment Health
Jirsaraie RJ, Barch DM, Bogdan R, Marek SA, Bijsterbosch JD, Sotiras A, Karcher NR.   +6 more
europepmc   +1 more source

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source