Results 31 to 40 of about 8,094 (259)

Lipid‐based Nano‐delivery systems as a promising strategy for the treatment of epilepsy: Current status and challenges

Epilepsia Open, EarlyView.
Abstract Objective Epilepsy is a prevalent chronic neurological disorder characterized by abnormal neuronal electrical activity. The primary treatment modality for individuals with epilepsy (PWE) is antiseizure medication (ASM). The multiple potential factors contributing to treatment resistance in epilepsy may be attributed to the inability of ASMs to
Priya Kannan Varshini, Arunachalam Divya, Kumar Sowndharya, Parthiban Jeevitha, Selvam Manoj, Ashiq Rahman, Athil Ahamed, Ravichandiran Abirahul, Paranthaman Subash, Sulekha Khute   +9 more
wiley   +1 more source

Disrupted Brain Structure and Function in Alzheimer's Disease Patients With Behavioral and Psychological Symptoms

iNew Medicine, EarlyView.
ABSTRACT Behavioral and psychological symptoms of dementia (BPSD) are highly prevalent in Alzheimer's disease (AD), but the underlying mechanisms are unclear. This study aims to elucidate the neuropathological mechanisms underlying BPSD by investigating gray matter volume (GMV) and brain connectivity in AD patients with and without BPSD.
Xuerui Pang, Linbo Xie, Mengdan Chen, Yi Ji, Yibing Yan, Shanshan Zhou, Panpan Hu, Xingqi Wu, Kai Wang   +8 more
wiley   +1 more source

Assessing the Czech Version of the Inventory of Personality Organization in Relation to Borderline Personality Disorder in the ICD‐11

Journal of Clinical Psychology, EarlyView.
ABSTRACT Objectives This study assessed the Czech version of the Inventory of Personality Organization (IPO‐CZ) in relation to borderline personality disorder (BPD) as defined in the ICD‐11 model for PDs and defensive functioning in BPDs. The IPO‐CZ was used as a proxy measure of personality functioning (PF), although not fully identical to the ...
Karel D. Riegel, Albert J. Ksinan
wiley   +1 more source

Familial Risk and Resilience Moderate the Association Between Intolerance of Uncertainty and Youth Suicidal Ideation

Journal of Clinical Psychology, EarlyView.
ABSTRACT Background Intolerance of uncertainty (IU), defined as a trait‐like tendency to respond to uncertain situations with negative cognitive, behavioral, and/or physiological reactions, is associated with increased risk for suicidal ideation (SI). Theory and research suggest that family‐level risk and resilience factors may shape how vulnerability ...
Alexa House, Shiane Toleson, Kathryn C. Jenkins, Kayla Kreutzer, Nicholas Allan, K. Luan Phan, Stephanie Gorka   +6 more
wiley   +1 more source

Sequelae of child maltreatment: Umbrella synthesis of 148 meta‐analyses on the mental health correlates

JCPP Advances, EarlyView.
Our umbrella synthesis found strong, often equivalent, associations between child maltreatment and all examined mental health difficulties. Different types of maltreatment appear to have comparably negative effects on mental health. If replicated, these findings may cause us to reconsider conventional wisdom that suggests some forms of CM are less ...
Barry Coughlan, Robbie Duschinsky, Marian J. Bakermans‐Kranenburg, Lianne Bakkum, Guy C. M. Skinner, Alfred Markham, Helen Beckwith, Marinus H. van Ijzendoorn   +7 more
wiley   +1 more source

‘Felt sense of anomaly’‐type transdiagnostic dissociative experiences in adolescents: Endorsed phenomenology and plausible mechanisms

JCPP Advances, EarlyView.
Abstract Background Research indicates dissociative experiences (DE) are prevalent in adolescents. However, the exact phenomenology and underlying mechanisms of dissociation in adolescence have yet to be clarified. The current study explores the presentation of, and possible psychological factors maintaining, dissociation in this population.
Emma Černis, Milan Antonović, Katie Lofthouse, Lottie Shipp, Polly Waite   +4 more
wiley   +1 more source

MOESM1 of Perception of alcohol policies by consumers of unrecorded alcohol - an exploratory qualitative interview study with patients of alcohol treatment facilities in Russia

, 2019
Additional file 1: Table S1. Sociodemographic characteristics of the study sites. Table S2. Prevalence and incidence of alcoholic psychoses and alcohol dependence for the researched regions. Table S3. Sample characteristics. Figure S1.
Lori Ross (7912868), Maria Neufeld (3627398), Hans-Ulrich Wittchen (161749), Jürgen Rehm (7912874), Carina Ferreira-Borges (7912871)   +4 more
core   +1 more source

Transdiagnostic profiles of socio‐affective functioning in adolescents at‐risk of poor mental health

JCPP Advances, EarlyView.
Abstract Background Adolescence is a developmental period during which many mental health problems emerge or worsen. Recently, there has been a shift towards identifying risk factors that predict psychopathology across a range of diagnostic boundaries—known as ‘transdiagnostic’ approaches.
Alex Lloyd, Duncan Astle, Tom (Chin‐Han) Wu, Nikolaus Steinbeis, Ritika Chokhani, Laura Lucas, Pasco Fearon, Essi Viding   +7 more
wiley   +1 more source

Transdiagnostic and symptom‐domain associations between mental illnesses and future self‐connectedness versus future self‐valence

JCPP Advances, EarlyView.
Abstract Background Future time perspective dimensions have been linked to various mental illnesses. Given the tendency for mental illnesses to co‐occur, it is necessary to disentangle associations between future‐oriented constructs and shared versus symptom‐domain‐specific psychopathology.
Yi Yang, Ingrid Obsuth, Jean‐Louis van Gelder, Denis Ribeaud, Manuel Eisner, Xinxin Zhu, Aja Louise Murray   +6 more
wiley   +1 more source

Alcoholism and Alcoholic Psychoses Trends in Late-Soviet and Post-Soviet Belarus

, 2018
Alcoholism /alcoholic psychoses ...
Razvodovsky, Y. E.
core