Results 111 to 120 of about 354,339 (315)

Preterm birth and structural brain alterations in early adulthood

NeuroImage: Clinical, 2014
Alterations in cortical development and impaired neurodevelopmental outcomes have been described following very preterm (VPT) birth in childhood and adolescence, but only a few studies to date have investigated grey matter (GM) and white matter (WM ...
Chiara Nosarti, Kie Woo Nam, Muriel Walshe, Robin M. Murray, Marion Cuddy, Larry Rifkin, Matthew P.G. Allin   +6 more
doaj   +1 more source

The many roads to psychosis: recent advances in understanding risk and mechanisms. [PDF]

, 2018
Schizophrenia is a chronic and severe mental illness which frequently leads to substantial lifelong disability. The past five years have seen major progress in our understanding of the complex genetic architecture of this disorder.
Bearden, Carrie E, Forsyth, Jennifer K
core  

Myoclonus-dystonia : distinctive motor and non-motor phenotype from other dystonia syndromes [PDF]

, 2019
Background: myoclonus-dystonia (M-D) due to a pathogenic variant of SGCE is an autosomal dominant inherited movement disorder. Apart from motor symptoms, psychiatric disorders are highly prevalent in patients with MD.
Bartels, Anna L., Bergmans, Bruno, Kuiper, Anouk, Santens, Patrick, Smit, Marenka, Tijssen, Marina A. J., Timmers, Elze R., van der Stouwe, A. M. Madelein, van der Veen, Sterre   +8 more
core   +2 more sources

Psychotropic medication use among community dwellers with and without Parkinson's disease – A nationwide cohort study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims We studied the prevalence of psychotropic use and psychotropic polypharmacy in persons with Parkinson's disease (PD) during a 10‐year follow‐up, because longitudinal studies on this topic are scarce although non‐motor symptoms of PD are often treated with psychotropics.
Noora Nieminen, Anna‐Maija Tolppanen, Valtteri Kaasinen, Marjaana Koponen, Sirpa Hartikainen   +4 more
wiley   +1 more source

HLA genotype testing for carbamazepine, oxcarbazepine and eslicarbazepine: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, EarlyView.
Carbamazepine is licensed in the United Kingdom for the treatment of epilepsy, bipolar disorder and trigeminal neuralgia. The related compounds oxcarbazepine and eslicarbazepine are licensed for the treatment of epilepsy. These drugs can cause immune‐mediated hypersensitivity reactions, which typically affect the skin, and can be of variable severity ...
Lucy Galloway, Cinzia Dello Russo, Nicholas Bass, Elvira Bramon, Helen Cross, Natalie Curley, Sarah Curran, Helen Davies, Jana De Villiers, William Evans, Bernhard Frank, Alice Groves, Judith Hayward, Jon Higham, Dyfrig A. Hughes, Shwe Sin Kyaw, Anthony G. Marson, Ailsa McLellan, Seth Mensah, Francis O'Neill, Jane Sargison, Sanjay M. Sisodiya, Jill Swan, Joanna M. Zakrewska, Munir Pirmohamed   +24 more
wiley   +1 more source

Through A Scanner Darkly: Neuropsychology and psychosis in Philip K. Dick's novel "A Scanner Darkly" [PDF]

, 2006
Partly motivated by his increasing brushes with psychosis, by the early 1970s the science fiction author Philip K. Dick was struggling with increasing doubts over the nature of reality and personal identity.
Bell, V
core  

Primary Psychoses Among Sentenced Prisoners in Finland

Criminal Behaviour and Mental Health, EarlyView.
ABSTRACT Background Recent studies suggest an increased prevalence of primary psychotic disorders among sentenced prisoners in Finland. Exploring the extent and correlates of lifetime primary psychoses through high‐quality data is crucial for early identification and effective interventions within correctional settings.
Petra Laivonen, Taina Laajasalo, Mika Rautanen   +2 more
wiley   +1 more source

AIM review tool: artificial intelligence for smarter systematic review screening

npj Artificial Intelligence
In this study, we present the AIM Review Tool, a modern web-based application that integrates active and supervised machine learning to accelerate the screening of publications for systematic reviews.
Sergio Mena, Esther Rituerto-González, Fiona Coutts, Jana von Trott, Grace R. Jacobs, Linda Bryant, Louise Moles, Nicoleta Sirbu, Liisi Promet, Dominic Oliver, Muhammad S. Ahmed, Paolo Fusar-Poli, Marian J. Bakermans-Kranenburg, Marinus H. van IJzendoorn, Nikolaos Koutsouleris, Paris Alexandros Lalousis   +15 more
doaj   +1 more source

Opioid Toxicity Following Concomitant Use of Macrolide Antibiotics with Fentanyl, Hydromorphone, or Oxycodone: A Population‐Based Study

Clinical Pharmacology &Therapeutics, EarlyView.
Fentanyl, hydromorphone, and oxycodone are metabolized by cytochrome P450 3A4 (CYP3A4). Co‐administration with CYP3A4‐inhibiting macrolides (clarithromycin or erythromycin) may increase opioid concentrations and overdose risk, but the clinical impact of these interactions is unknown.
Tony Antoniou, Joanna Yang, David N. Juurlink, Joanne M.‐W. Ho, Muhammad Mamdani, Fangyun Wu, Mina Tadrous, Tara Gomes   +7 more
wiley   +1 more source

Physical Health and Transition to Psychosis in People at Clinical High Risk

Biomedicines
Background: The clinical high risk for psychosis (CHR-P) construct represents an opportunity for prevention and early intervention in young adults, but the relationship between risk for psychosis and physical health in these patients remains unclear ...
Andrea De Micheli, Umberto Provenzani, Kamil Krakowski, Dominic Oliver, Stefano Damiani, Natascia Brondino, Philip McGuire, Paolo Fusar-Poli   +7 more
doaj   +1 more source