Results 111 to 120 of about 241,274 (304)

Irregular visits in longitudinal studies: Comparing inverse intensity of visit weighting and imputation in a causal analysis of antidepressant therapeutic treatment

Canadian Journal of Statistics, EarlyView.
Abstract Irregular observation times are common in longitudinal observational studies and can affect causal inferences. We use data from electronic health records of Kaiser Permanente Washington patients in the United States who initiated an antidepressant medication between 2008 and 2018, with a confirming diagnosis of depression. We are interested in
Janie Coulombe, Erica E. M. Moodie, Susan M. Shortreed   +2 more
wiley   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

Striatal dopamine D2/D3 receptor regulation of human reward processing and behaviour

Nature Communications
Signalling at dopamine D2/D3 receptors is thought to underlie motivated behaviour, pleasure experiences and emotional expression based on animal studies, but it is unclear if this is the case in humans or how this relates to neural processing of reward ...
Martin Osugo, Matthew B. Wall, Pierluigi Selvaggi, Uzma Zahid, Valeria Finelli, George E. Chapman, Thomas Whitehurst, Ellis Chika Onwordi, Ben Statton, Robert A. McCutcheon, Robin M. Murray, Tiago Reis Marques, Mitul A. Mehta, Oliver D. Howes   +13 more
doaj   +1 more source

Population‐Stratified Distributions of Post‐Mortem Blood Drug Concentrations: An Epidemiological Framework for Contextual Interpretation

Drug Testing and Analysis, EarlyView.
Post‐mortem blood drug concentrations exhibit substantial overlap between deaths in which a drug was implicated and those in which it was not. Analysis of over 58,000 NPSUM cases demonstrates that demographic stratification does not resolve this uncertainty, reinforcing the need for contextual, evidence‐based interpretation rather than concentration ...
Thikra Algahtani, Kirsten L. Rock, Kathleen Rice‐Davies, Rebecca Lo, Benedict Morley, Stephen Morley, Caroline S. Copeland   +6 more
wiley   +1 more source

AIM review tool: artificial intelligence for smarter systematic review screening

npj Artificial Intelligence
In this study, we present the AIM Review Tool, a modern web-based application that integrates active and supervised machine learning to accelerate the screening of publications for systematic reviews.
Sergio Mena, Esther Rituerto-González, Fiona Coutts, Jana von Trott, Grace R. Jacobs, Linda Bryant, Louise Moles, Nicoleta Sirbu, Liisi Promet, Dominic Oliver, Muhammad S. Ahmed, Paolo Fusar-Poli, Marian J. Bakermans-Kranenburg, Marinus H. van IJzendoorn, Nikolaos Koutsouleris, Paris Alexandros Lalousis   +15 more
doaj   +1 more source

Researchers' Perspectives and Guidelines on the Reporting of Lived Experience Involvement in Eating Disorder Research

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objectives There is an increasing trend towards embedding consumer and community involvement in all health and medical research. The Executive Committee of the International Journal of Eating Disorders (IJED) disseminated a survey for eating disorder researchers investigating their practices and perspectives regarding Patient and Public ...
Tracey D. Wade, Marcela Radunz, Jake Linardon, Scott J. Crow, Ata Ghaderi, Anja Hilbert, Kelly L. Klump, B. Timothy Walsh, Ruth Weissman   +8 more
wiley   +1 more source

Mechanisms of an Inhibitory Control Training to Reduce Binge Eating—The Randomized Controlled MIND BINGES Trial

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Psychotherapy is the first‐line treatment for eating disorders (EDs), yet only about half of patients benefit long‐term. Bulimia nervosa (BN), Binge‐Eating‐Disorder (BED), and non‐underweight EDs with regular binge eating (> 2 binge‐eating episodes per month within the last 3 months) (OSFED/UFED) form a transdiagnostic group ...
Sebastian M. Max, Katrin E. Giel, Christian Plewnia, Simone Weller, Andreas J. Fallgatter, Veronika Lossa, Stephan Zipfel, Kathrin Schag   +7 more
wiley   +1 more source

Physical Health and Transition to Psychosis in People at Clinical High Risk

Biomedicines
Background: The clinical high risk for psychosis (CHR-P) construct represents an opportunity for prevention and early intervention in young adults, but the relationship between risk for psychosis and physical health in these patients remains unclear ...
Andrea De Micheli, Umberto Provenzani, Kamil Krakowski, Dominic Oliver, Stefano Damiani, Natascia Brondino, Philip McGuire, Paolo Fusar-Poli   +7 more
doaj   +1 more source

Mental Health and Well‐Being Across the Eating Disorder Spectrum—From Milder Symptoms of Disordered Eating Behaviors to Diagnosed Eating Disorders

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective This study examined differences in mental health and well‐being, risk behaviors, suicidality, and social functioning across a proposed eating disorder (ED) spectrum, ranging from no ED symptoms to clinically diagnosed EDs. Methods We examined 44,303 participants in the 18‐year follow‐up in the Danish National Birth Cohort (DNBC‐18 ...
Anne V. Aurup, Andrea Joensen, Else Marie Olsen, Nadia M. Mikkelsen, Stine Danielsen, Pernille Stemann Larsen, Katrine Strandberg‐Larsen   +6 more
wiley   +1 more source

Emotion Regulation in Response to Stress in the Daily Lives of Women With and Without Eating Disorders: An Ecological Momentary Assessment Study

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Emotion regulation difficulties are known risk/maintenance factors for eating disorders (EDs). Few studies have investigated use of adaptive/maladaptive emotion regulation strategies in people with EDs, especially using ecologically valid data.
Sarah E. Racine, Ege Bicaker, Alexia E. Miller, Vittoria Trolio, Lisa Y. Zhu   +4 more
wiley   +1 more source