Results 61 to 70 of about 39,047 (291)

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Contextual Cognitive-Behavioral Therapies Across the Psychosis Continuum [PDF]

European Psychologist, 2017
Abstract. Considering several etiologic, therapeutic, and comorbidity-related factors, a psychosis continuum model has been proposed for the understanding and treatment of psychotic disorders. Within the new emerging treatment approaches, Contextual Cognitive-Behavioral Therapies (CCBT) seem to hold promise for the psychosis continuum.
Martins, Maria João Ruivo Ventura, Castilho, Paula, Carvalho, Célia Barreto, Pereira, Ana Telma, Santos, Vitor, Gumley, Andrew, Macedo, António Ferreira de   +6 more
openaire   +3 more sources

Schizophrenia, Not a Psychotic Disorder: Bleuler Revisited

Frontiers in Psychiatry, 2019
Current diagnostic criteria delineate schizophrenia as a discrete entity essentially defined by positive symptoms. However, the role of positive symptoms in psychiatry is being questioned.
Alexandre Andrade Loch, Alexandre Andrade Loch   +1 more
doaj   +1 more source

The ‘continuum of psychosis’: scientifically unproven and clinically impractical [PDF]

British Journal of Psychiatry, 2010
SummaryThe limitations of current diagnostic categories are well recognised but their rationale, advantages and utility are often ignored. The scientific support for a ‘continuum of psychosis' is limited, and the examination of whether categories, a continuum or more than one continua, and alternatives such as subtypes or hybrid models, best account ...
Stephen M, Lawrie, Jeremy, Hall, Andrew M, McIntosh, David G C, Owens, Eve C, Johnstone   +4 more
openaire   +2 more sources

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Exploring the role of TNF-α, TGF-β, and IL-6 serum levels in categorical and noncategorical models of mood and psychosis

Scientific Reports
Psychotic and mood disorders are discussed as part of the same continuum. The potential role of immune dysregulation in defining their clinical presentations, however, remains unclear.
Maja Pantovic-Stefanovic, Milica Velimirovic, Vladimir Jurisic, Marija Puric, Marta Gostiljac, Sara Dodic, Ivana Minic, Milica Nesic, Tatjana Nikolic, Natasa Petronijevic, Maja Ivkovic, Bojana Dunjic-Kostic   +11 more
doaj   +1 more source

Are genetic risk factors for psychosis also associated with dimension-specific psychotic experiences in adolescence? [PDF]

, 2014
Psychosis has been hypothesised to be a continuously distributed quantitative phenotype and disorders such as schizophrenia and bipolar disorder represent its extreme manifestations.
A Boyd, A Fossati, AD Johnson, AG Cardno, AH Fanous, AH Fanous, AH Fanous, Alastair G. Cardno, Angelica Ronald, C M, Tuvblad, CCH Lin, CMA Haworth, Daniel Freeman, Dominika Sieradzka, E Cummings, E Cyhlarova, E Fonseca-Pedrero, EM Derks, Emma L. Meaburn, F Dudbridge, Frank Dudbridge, FV Rijsdijk, I Kelleher, J Van Os, J Welham, J Yang, James Bennett Potash, JTW Wigman, L Paternoster, M Trzaskowski, MG Vollema, NR Wray, P DeRosse, P DeRosse, P Lichtenstein, P McGuffin, PF Sullivan, Philip McGuire, R Plomin, R Poulton, RJ Pruim, Robert A. Power, Robert Plomin, S Purcell, S Zammit, SE Bergen, SH Lee, SH Lee, SM Purcell, TM Laursen, YM Hur   +50 more
core   +6 more sources

Temporal Trends in and Associations With Nonsteroidal Anti‐inflammatory Drug Prescription in Adult and Pediatric Patients With Inflammatory Bowel Disease

Arthritis Care &Research, EarlyView.
Objective Recent inflammatory bowel disease (IBD) treatment guidelines have recommended against nonsteroidal anti‐inflammatory drug (NSAID) use despite prevalent musculoskeletal symptoms and opioid overuse in this population. Given the discordance between changing national guidelines and potential clinical utility, we sought to assess national temporal
Adam S. Mayer, Rui Xiao, Andrew Grossman, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +5 more
wiley   +1 more source

Evaluation of a brief online multi-index assessment for predicting increased psychotic-like experiences in the community: A perceptual, cognitive and affective approach.

Schizophrenia Research: Cognition
Research has shown that impairments in perception, reasoning, and social cognition are evident across the psychosis continuum and are implicated in the transition from subclinical symptoms to clinical psychosis.
Caroline Cullen, Keith Gaynor, Klaus Kessler   +2 more
doaj   +1 more source

Understanding jumping to conclusions in patients with persecutory delusions: working memory and intolerance of uncertainty

, 2014
Background. Persecutory delusions are a key psychotic experience. A reasoning style known as ‘jumping to conclusions’ (JTC) – limited information gathering before reaching certainty in decision making – has been identified as a contributory factor in the
Cordwell, J., Dunn, G., Freeman, D., Kingdon, D., Mander, H., Pugh, K., Startup, H., Wingham, G., Černis, E.   +8 more
core   +1 more source