Results 61 to 70 of about 772,498 (301)

Sleep and the hypothalamic-pituitary-adrenocortical activity : biological processes associated with psychosocial adjustment during childhood and adolescence [PDF]

, 2015
: Sleep and the hypothalamic-pituitary-adrenocortical (HPA) activity are two biological processes that play a vital role for physical and mental health as well as general well-being.
Perkinson-Gloor, Nadine
core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Mentalization-based intervention for parents with elevated parenting stress: protocol of a RCT of the lighthouse parenting programme in China

Frontiers in Psychology
The period of childhood and early adolescence, specifically prior to the age of 14, is a critical phase for the prevention of mental health problems. Nevertheless, prevention programs for this age group remain under recognized in China.
Ruoshi Hu, Ruoshi Hu, Svenja Taubner, Anna Georg   +3 more
doaj   +1 more source

Psychological impact of COVID‐19 pandemic and lockdown among the population involved in tourism sector in Lakeside of Pokhara: A qualitative study

Health Science Reports, 2023
Background and Aims The COVID‐19 pandemic has exerted a substantial influence on every sector of people's lives worldwide, including Nepal. The tourism industry is not exceptional.
Rajesh Paudel, Seema Khadka, Jeetendra Rai, Rakesh Singh   +3 more
doaj   +1 more source

Modeling Progressive Brain Volume Losses in Chronic Moderate Severe Traumatic Brain Injury: Extensive, but Attenuating

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progressive brain atrophy has now been widely observed in the chronic stages of moderate–severe traumatic brain injury (msTBI), but there is only coarse information regarding its prevalence and magnitude, and whether rate of atrophy accelerates or attenuates across time. We examined these questions in a Canadian inception cohort from
Robin E. A. Green, Brenda Colella, Alana Changoor, David J. Mikulis, Adrienne Li, Kadeen Johns, Georges A. Monette   +6 more
wiley   +1 more source

Protocol for a systematic review and meta-analysis on the associations between short rest periods between shifts and health, function, and behavioral outcomes

Systematic Reviews
Purpose This paper presents a protocol for a planned systematic review and meta-analysis that will investigate the impact of short rest periods between shifts (i.e., quick returns,
Filip Borgen Andersen, Ståle Pallesen, Ingvild Thorsen Egaas, Øystein Vedaa, Morten Birkeland Nielsen, Erlend Sunde, Øystein Holmelid, Bjarte Birkeland Kysnes, Bjørn Bjorvatn, Siri Waage, Annina Ropponen, Anne Helene Garde, Anna Dahlgren, Ingebjørg Louise Rockwell Djupedal, Anette Harris   +14 more
doaj   +1 more source

Employment Trajectories of Patients With Systemic Lupus Erythematosus and Factors Driving Transitions Between States

Arthritis Care &Research, EarlyView.
Objective Systemic lupus erythematosus (SLE) significantly impacts employment capacity. This study aimed to investigate the impact of burden of disease activity, damage, and treatment on employment outcomes and transitions in patients with SLE. Methods Using data from a single center, we analyzed employment transitions, adjusted mean disease activity ...
Javier Mencia‐Ledo, Zahi Touma, Laura Whittall Garcia, Dafna D. Gladman, Behdin Nowrouzi‐Kia   +4 more
wiley   +1 more source

Psychosocial consequences of surviving cancer diagnosed and treated in childhood versus in adolescence/young adulthood: A call for clearer delineation between groups

, 2022
Surviving childhood cancer and surviving cancer in adolescence or young adulthood may present with psychosocial similarities and differences.
Wakefield, Claire E., Darlington, Anne Sophie E., van Erp, Loes M.E., Loes M. E. van Erp, Richard J. Cohn, Winette T. A. van der Graaf, Martha A. Grootenhuis, Claire E. Wakefield, van der Graaf, Winette T. A., Cohn, Richard J., van der Graaf, Winette T.A.; id_orcid, Anne‐Sophie E. Darlington, Grootenhuis, Martha A., Darlington, Anne-Sophie E., van Erp, Loes M. E.   +14 more
core   +1 more source

Factors Associated With Fibromyalgia Diagnosis Among People Meeting Criteria: Results From UK Biobank

Arthritis Care &Research, EarlyView.
Objective The diagnosis of fibromyalgia (FM) is challenging due to the absence of definitive biomarkers, numerous overlapping comorbidities, and its reliance on patient‐reported symptoms. Discrepancies between diagnostic criteria and clinical practice imply the possibility of diagnostic biases, complicating timely and accurate identification.
Sung‐A Kim, Gary J. Macfarlane, Marcus J. Beasley   +2 more
wiley   +1 more source

Outcomes of integrating livelihood into mental health and psychosocial support program among survivors of torture: A mixed-method study from western Nepal

Torture
Introduction: From 1996 to 2006, Nepal experienced a decade-long armed conflict that adversely impacted survivors of torture. The conflict posed threats to various facets of their lives, such as men-tal health, socio-economic status, human ...
Diwakar Khanal, Sabina Sitaula, Pitambar Koirala, Kamal Gautam, Suraj Koirala   +4 more
doaj   +1 more source