Results 81 to 90 of about 752,078 (302)

Mental health and psychosocial support services in primary health care in Nepal: perceived facilitating factors, barriers and strategies for improvement

BMC Psychiatry, 2020
Background The barriers and facilitating factors for integrating mental health into primary health care have been well documented in the literature, but little is known about the perspectives of primary health care workers (who provide integrated mental ...
Nawaraj Upadhaya, Upasana Regmi, Dristy Gurung, Nagendra P. Luitel, Inge Petersen, Mark J. D. Jordans, Ivan H. Komproe   +6 more
doaj   +1 more source

Alzheimer's Disease Beyond Amyloid: Lessons From Atherosclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Marcello Ciaccio, Luisa Agnello
wiley   +1 more source

Auditory–Tactile Congruence for Synthesis of Adaptive Pain Expressions in RoboPatients

Advanced Robotics Research, EarlyView.
In this work, we explore auditory–tactile congruence for synthesizing adaptive vocal pain expressions in robopatients. Using a robopatient platform that integrates vocal pain sounds with palpation forces, we conducted 7680 trials across 20 participants.
Saitarun Nadipineni, Chapa Sirithunge, Yue Xie, Fumiya Iida, Thilina Dulantha Lalitharatne   +4 more
wiley   +1 more source

Evidence based cardiology - Psychosocial factors in the aetiology and prognosis of coronary heart disease: systematic review of prospective cohort studies [PDF]

, 1999
Summary points: In healthy populations, prospective cohort studies show a possible aetiological role for type A/hostility (6/14 studies), depression and anxiety (11/11 studies), psychosocial work characteristics (6/10 studies), social support (5/8 ...
Marmot, M., Hemingway, H.
core  

Optimizing a community-based intervention to improve help-seeking for depression care: study protocol for a randomized factorial trial

Trials
Background Depression is a common mental health issue that can be effectively managed in primary and community health care settings. However, there is a significant gap between the number of individuals in need of care and those who actually receive ...
Nagendra P. Luitel, Brandon A. Kohrt, Bishnu Lamichhane, Anvita Bhardwaj, Kamal Gautam, Mark JD Jordans   +5 more
doaj   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Psychosocial work stressors and risk of type 2 diabetes: effect, impact and mechanisms [PDF]

, 2010
BACKGROUND: As early as the 17th century diabetes was linked to psychosocial stressors, yet this association still remains elusive. The impact of psychosocial work stressors on diabetes is also unknown, as are the pathways involved.
Heraclides, A.
core  

Match of psychosocial risk and psychosocial care in families of a child with cancer [PDF]

, 2017
Objective: The Psychosocial Assessment Tool (PAT) was developed to screen for psychosocial risk, aimed to be supportive in directing psychosocial care to families of a child with cancer.
Boer, Y. de, Streng, Isabelle, Streng, I., S.A. Schepers, van Dijk-Lokkart, EM, Bergh, E.M. van den, Dijk-Lokkart, E.M. van, Y. de Boer, M.A. Grootenhuis, Grootenhuis, MA, Schepers, S.A., I. Streng, van den Bergh, E. M. M., C.M. Verhaak, Verhaak, C. M., E.M.M. van den Bergh, van Dijk-Lokkart, E. M., Grootenhuis, M. A., Verhaak, C.M., den Boer, Y, Nicolaas, S M S, Sint Nicolaas, S.M., Schepers, S A, Schepers, S. A., E.M. van Dijk-Lokkart, de Boer, Y., van den Bergh, EMM, Grootenhuis, M.A., Verhaak, CM, van den Bergh, E. M.M., Sint Nicolaas, S. M., S.M. Sint Nicolaas   +31 more
core   +1 more source

Tumor Exposomics: A New Paradigm for Individualized Continuous Exposure Monitoring

Advanced Science, EarlyView.
Tumor exposomics integrates continuous monitoring of environmental exposures, endogenous biological responses, and behavioral factors within a unified temporal framework. By combining multimodal sensing technologies with AI‐enabled causal modeling, this emerging paradigm reconstructs exposure‐damage trajectories and supports individualized dynamic risk
Kaicheng Shen, Weiyi Wang, Yang Wang, Yiqiang Wu, Xiaohong Liu, Wei Zhang, Juanjuan Ou   +6 more
wiley   +1 more source

Chronic Stress Promotes Gastric Cancer Metastasis by Inducing Microbiota‐Associated Kynurenine Accumulation and Macrophage Remodeling

Advanced Science, EarlyView.
Chronic stress reshapes the gut microbiota and enriches Lactobacillus reuteri, promoting microbiota‐associated kynurenine accumulation through altered tryptophan metabolism. Kynurenine drives immunosuppressive remodeling of tumor‐associated macrophages through TNFR2–C/EBPβ signaling, thereby enhancing gastric cancer dissemination.
Sicheng Zhao, Zhiyuan Song, Jingcheng Zhang, Jiaheng Lou, Shuo Zhang, Boqiang Liu, Yunhai Wei, Fengmei Qiu, Tao Jiang, Guangji Zhang   +9 more
wiley   +1 more source