Results 111 to 120 of about 24,654 (226)

Genetic Architecture of Addiction‐Relevant Behaviors in Outbred Sprague–Dawley Rats Reveals Loci for Anxiety‐Like and Nociceptive Traits

open access: yesGenes, Brain and Behavior, Volume 25, Issue 3, June 2026.
Genome‐wide association analyses in outbred Sprague–Dawleys identified loci for anxiety‐like and nociceptive behavior on chromosomes 1, 14, and 17, which are distinct from facets of exploratory locomotion significant in our GWAS of a F2 intercross of selectively bred high‐ and low‐responder (to a novel environment) Sprague–Dawleys.
Apurva S. Chitre   +11 more
wiley   +1 more source

5-HT6R Viral Vector-Mediated Indirect Pathway Activation in the Dorsolateral Striatum: A Discussion on Basal Ganglia Habitual and Goal-Directed Circuits [PDF]

open access: yes, 2018
Altering maladaptive behavioral tendencies is relevant for clinical interventions, making research on underlying mechanisms of habit essential. Mechanisms of habit are explored here with differential activation of the indirect pathway in the basal ...
Winn, Caleb S
core   +1 more source

Orexin-Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine [PDF]

open access: yes, 2015
Release of the neuropeptides corticotropin-releasing factor (CRF) and orexin-A in the ventral tegmental area (VTA) play an important role in stress-induced cocaine-seeking behavior.
Aguinaga, David   +17 more
core   +1 more source

Rationale for psychostimulants in ADHD [PDF]

open access: yesBMJ, 2005
EDITOR—Confusion about levels of diagnosis causes most debate about psychostimulants in childhood behavioural disorders.1 DSM-IV definitions are all syndromes—that is, symptoms and signs unrelated to pathology and aetiology. Most effective therapies treat pathology and aetiology; syndromes can be treated only symptomatically.
openaire   +2 more sources

Multimodal MRI Reveals Brain Structural Differences and Executive Dysfunction in Early Methamphetamine Abstinence

open access: yesBrain and Behavior, Volume 16, Issue 5, May 2026.
In a sample of 13 early‐abstinent methamphetamine users (≤30 days) and 14 controls, multimodal MRI revealed lower cortical volume in frontal and lingual regions and thickness of the lateral occipital and lingual cortex. These structural changes accompanied poorer executive performance, suggesting dose‐related grey‐matter vulnerability in visual ...
Ben Bristow   +13 more
wiley   +1 more source

Examination of the Monoamine Oxidase A Gene Promoter on Motivation to Exercise and Levels of Voluntary Physical Activity [PDF]

open access: yes, 2017
Purpose: The purpose of this study was to examine the genetic basis underlying voluntary exercise. Monoamine oxidase A (MAO-A) is an enzyme that acts on monoamine neurotransmitters, such as dopamine, to cause inactivation. There are several polymorphisms
Kinney, Erin M.
core   +1 more source

Temporal Trends in the Epidemiology of Eating Disorders Between 2000 and 2022: A Danish Register Study of Their Incidence and Comorbidities

open access: yesEuropean Eating Disorders Review, Volume 34, Issue 3, Page 749-769, May 2026.
ABSTRACT Background Eating disorders are debilitating illnesses that often co‐occur with other psychiatric disorders and somatic diseases. Evidence indicates that the incidence of eating disorders has been increasing. We first examine the landscape of EDs over time, including the COVID‐19 period, via assessing the incidence of anorexia nervosa (AN ...
Nadia Micali   +4 more
wiley   +1 more source

Unlocking the Quality Potential of Liberoid Coffee: Advances in Composition, Processing, and Microbial Fermentation

open access: yesComprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT Liberoid coffee (Coffea liberica group), comprising varieties of Liberica and Excelsa coffee types, is gaining attention for its unique chemical composition and sensory potential. However, its quality remains under‐optimized due to limited understanding of genotype‐specific traits and processing responses.
Noor Ariefandie Febrianto, Fan Zhu
wiley   +1 more source

“Wide-Awake Drunk”: Observing the Combined Effects of Alcohol and Caffeine on Somatic Withdrawal Signs in C57BL/6J Mice [PDF]

open access: yes, 2019
Caffeine is one of the most widely used psychoactive stimulants in the world and is often used in combination with other substances. The combination of caffeine and alcohol has been shown to induce a stimulated, rather than sedated state, which may ...
Jenkins, Montana
core   +1 more source

GLP‐1 Receptor Agonists for Treating Alcohol Use Disorder: A Critical Review

open access: yesAlcohol, Clinical and Experimental Research, Volume 50, Issue 5, May 2026.
This narrative review of the development of GLP‐1 receptor agonists provides a foundation for both preclinical and clinical research on their use for treating alcohol use disorder (AUD). Both observational studies using real‐world data and randomized controlled clinical trials support the potential utility of these medications for treating AUD ...
Sean Woo   +6 more
wiley   +1 more source

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