Results 31 to 40 of about 52,275 (325)

Dwelling in prolonged grief: Resting state functional connectivity during oxytocin and placebo administration

Human Brain Mapping, Volume 44, Issue 1, Page 245-257, January 2023., 2023
In older adults who experienced the death of a partner, higher prolonged grief symptoms were associated with less anticorrelation between retrosplenial default network and cingulo‐opercular networks during resting state, and more dwell time in a dynamic functional connectivity state involving positive correlations between large‐scale brain networks ...
Saren H. Seeley, Jessica R. Andrews‐Hanna, John J. B. Allen, Mary‐Frances O'Connor   +3 more
wiley   +1 more source

Medical Knowledge Graph QA for Drug-Drug Interaction Prediction based on Multi-hop Machine Reading Comprehension [PDF]

, 2022
Drug-drug interaction prediction is a crucial issue in molecular biology. Traditional methods of observing drug-drug interactions through medical experiments require significant resources and labor. This paper presents a medical knowledge graph question answering model, dubbed MedKGQA, that predicts drug-drug interaction by employing machine reading ...
arxiv   +1 more source

Assessment of Potential Drug–Drug Interactions of Psycholeptics and Antidepressants in Outpatient Settings

Pharmacy
Mental health is an important segment in preserving overall health and represents a significant public health issue. In modern times, mental health disorders have risen, often requiring complex pharmacotherapy and chronic monitoring.
Iva Marović, Ivana Marinović, Vesna Bačić Vrca, Ivana Samardžić   +3 more
doaj   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Development of Carbon‐11 Labeled Pyrimidine Derivatives as Novel Positron Emission Tomography (PET) Agents Enabling Brain Sigma‐1 Receptor Imaging

Advanced Science, EarlyView.
Novel carbon‐11 labeled pyrimidine derivatives are developed as PET imaging probes for visualizing sigma‐1 receptors in the brain. [11C]CNY‐01 demonstrates superior brain uptake and binding specificity in both rodents and non‐human primates. The study reveals decreased sigma‐1 receptor expression in Alzheimer's disease, offering a promising tool for ...
Ping Bai, Ashley Gomm, Chi‐Hyeon Yoo, Prasenjit Mondal, Fleur Marie Lobo, Hui Meng, Yanting Zhou, Weiyao Xie, Hsiao‐Ying Wey, Rudolph E. Tanzi, Can Zhang, Changning Wang, Yu Lan   +12 more
wiley   +1 more source

Deep learning analysis of intracranial EEG for recognizing drug effects and mechanisms of action [PDF]

arXiv, 2020
Drug-target interaction (DTI) prediction has become a foundational task in drug repositioning, polypharmacology, drug discovery, as well as drug resistance and side-effect prediction. DTI identification using machine learning is gaining popularity in these research areas.
arxiv  

Utilizing Caenorhabditis Elegans as a Rapid and Precise Model for Assessing Amphetamine‐Type Stimulants: A Novel Approach to Evaluating New Psychoactive Substances Activity and Mechanisms

Advanced Science, EarlyView.
This study uses Caenorhabditis elegans to assess the activity of amphetamine‐type stimulants (ATS) and their analogs. The research highlights the roles of dopamine and serotonin pathways, distinguishes chiral forms of ATS, and identifies structure‐activity relationships. These findings provide a rapid and cost‐effective model for evaluating the effects
Yuanpeng Li, Hongyuan Li, Hongshuang Wang, Xiaohui Wang   +3 more
wiley   +1 more source

Risk and protective factors for marijuana use and problems with use in a national sample of female Ecuadorian secondary school students

International Journal of Psychology, Volume 58, Issue 1, Page 85-89, February 2023., 2023
This study investigated risk and protective factors for marijuana use and problems with use in Ecuadorian girls in an attempt to inform this growing problem. Female secondary school students (N = 16,310; M = 15.02, SD = 1.73 years) who completed the 2016 national survey of drug use participated. The likelihood of lifetime marijuana use, reported by 7.3%
Daniela Ocaña‐Gordillo, Wendy Kliewer
wiley   +1 more source

Multi-View Substructure Learning for Drug-Drug Interaction Prediction [PDF]

arXiv, 2022
Drug-drug interaction (DDI) prediction provides a drug combination strategy for systemically effective treatment. Previous studies usually model drug information constrained on a single view such as the drug itself, leading to incomplete and noisy information, which limits the accuracy of DDI prediction.
arxiv  

Hepatotoxicity of Psychotropic Drugs [PDF]

Hepatology, 1999
Psychotropic drugs with hepatotoxic potential can be classified based on their intended use: 1) antipsychoticsneuroleptics including phenothiazines, butyrophenones, and clozapine; 2) antidepressants including tricyclics, serotonin reuptake inhibitors, and monoamine oxidase (MAO) inhibitors; 3) anti-anxiety drugs such as benzodiazepines; 4 ...
Khaled Selim, Neil Kaplowitz
openaire   +3 more sources