Results 51 to 60 of about 52,275 (325)
A clustering and graph deep learning-based framework for COVID-19 drug repurposing [PDF]
arXiv, 2023 Drug repurposing (or repositioning) is the process of finding new therapeutic uses for drugs already approved by drug regulatory authorities (e.g., the Food and Drug Administration (FDA) and Therapeutic Goods Administration (TGA)) for other diseases. This involves analyzing the interactions between different biological entities, such as drug targets ...
arxiv
Animal Models and Experimental Medicine, EarlyView.In an ethanol (EtOH)‐treated mouse model, increases in the NLRP3 inflammasome proteins, PC degeneration, and motor coordination disorders were observed. DIP suppressed the NLRP3‐ASC‐caspase‐1 signaling pathway, and alleviated the motor deficits and cerebellar pathological changes in chronic EtOH‐treated mice.
Jian Zhang +5 more
wiley +1 more source
Key Factors that Influence Consumer Preferences for Natural‐Hyped Products
Psychology &Marketing, Volume 40, Issue 2, Page 373-390, February 2023., 2023 Abstract Natural‐hyped products are receiving greater attention from and acceptance by consumers worldwide. Environmental factors that foster the demand for natural‐hyped products, specifically hemp‐based products include the deregulation of the cannabis industry and greater consumer desire for natural foods.
Franklin Velasco +3 more
wiley +1 more source
Annals of Neurology, EarlyView.Objective The objective is to evaluate cognitive and behavioral progression and identify early predictors of these changes in a cohort of amyotrophic lateral sclerosis (ALS) patients. Methods A total of 161 ALS patients were tested at diagnosis (T0), and 107 were re‐tested after 1 year (T1) using cognitive/behavioral tests. All patients underwent whole‐
Barbara Iazzolino +13 more
wiley +1 more source
Antidepressant and antipsychotic use in an Italian pediatric population
BMC Pediatrics, 2011 Background The safety and effectiveness of psychotropic drug use in the paediatric population is widely debated, in particular because of the lack of data concerning long term effects.
Lombardo Giuseppe +9 more
doaj +1 more source
Emerging and experimental treatments for COVID-19 and drug interactions with psychotropic agents
Therapeutic Advances in Psychopharmacology, 2020 As yet, no agents have been approved for the treatment of COVID-19, although several experimental drugs are being used off licence. These may have serious adverse effects and potential drug interactions with psychotropic agents.
Delia Bishara +2 more
doaj +1 more source
Drug prescription clusters in the UK Biobank: An assessment of drug-drug interactions and patient outcomes in a large patient cohort [PDF]
arXiv, 2022 In recent decades, there has been an increase in polypharmacy, the concurrent administration of multiple drugs per patient. Studies have shown that polypharmacy is linked to adverse patient outcomes and there is interest in elucidating the exact causes behind this observation.
arxiv
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Nursing Open, Volume 10, Issue 2, Page 1016-1028, February 2023., 2023 Abstract Aim The aim of the study was to reach consensus on modifiable risk factors for a novel system of care to address Manifestations of Frailty in hospitalized older adults. Design Consensus study. Method A modified nominal group technique, incorporating expert group face‐to‐face interaction, review of existing evidence and pre/post‐meeting ...
Susanne Coleman +17 more
wiley +1 more source
Cellular & Molecular Biology LettersBackground Postoperative cognitive dysfunction (POCD) is a common complication after anesthesia/surgery, especially among elderly patients, and poses a significant threat to their postoperative quality of life and overall well-being.
Wei-Feng Wu +14 more
doaj +1 more source