Results 71 to 80 of about 52,275 (325)

Zero-shot Learning of Drug Response Prediction for Preclinical Drug Screening [PDF]

arXiv, 2023
Conventional deep learning methods typically employ supervised learning for drug response prediction (DRP). This entails dependence on labeled response data from drugs for model training. However, practical applications in the preclinical drug screening phase demand that DRP models predict responses for novel compounds, often with unknown drug ...
arxiv  

In vitro metabolism study of ADB‐P‐5Br‐INACA and ADB‐4en‐P‐5Br‐INACA using human hepatocytes, liver microsomes, and in‐house synthesized references

Drug Testing and Analysis, EarlyView.
Analyzing hepatocytes and liver microsomes samples along with synthesized references. Complete structure elucidation of major metabolites was possible, and biomarkers for both ADB‐P‐5Br‐INACA and ADB‐4en‐P‐5Br‐INACA were suggested. Abstract Synthetic cannabinoids (SCs) remain a major public health concern, as they continuously are linked to severe ...
Tobias Rautio, Robin Obrist, Lucas Krebs, Therése Klingstedt, Johan Dahlén, Xiongyu Wu, Henrik Gréen   +6 more
wiley   +1 more source

Simultaneous monitoring of activity and heart rate variability in depressed patients: A pilot study using a wearable monitor for 3 consecutive days

Neuropsychopharmacology Reports, Volume 42, Issue 4, Page 457-467, December 2022., 2022
By using a wearable sensor we examined 3‐dimensional acceleration and heart rate variability (HRV) simultaneously in depressive episode of mood disorders. We found reduced activity and altered HRV indices in depressed patients, compared with healthy participants, particularly in males. Moreover, we found that sympathetic load during sleep significantly
Norie Koga, Yoko Komatsu, Ryo Shinozaki, Ikki Ishida, Yusuke Shimizu, Sonoko Ishimaru, Hiroshi Kunugi   +6 more
wiley   +1 more source

Clinical connectivity map for drug repurposing: using laboratory tests to bridge drugs and diseases [PDF]

arXiv, 2020
Drug repurposing has attracted increasing attention from both the pharmaceutical industry and the research community. Many existing computational drug repurposing methods rely on preclinical data (e.g., chemical structures, drug targets), resulting in translational problems for clinical trials.
arxiv  

High‐throughput liquid chromatography‐vacuum differential mobility spectrometry‐mass spectrometry for the analysis of isomeric drugs of abuse in human urine

Drug Testing and Analysis, EarlyView.
This report describes the potential of vacuum differential mobility spectrometry (DMS) as an additional separation dimension to reduce liquid chromatography (LC‐MS) analysis time while maintaining good quantitative performance. A 1‐min trap/elute LC‐vDMS‐SIM/MS method for quantification of 11 drugs of abuse was developed and applied to the analysis of ...
Maria Fernanda Cifuentes Girard, Patrick Knight, Gérard Hopfgartner   +2 more
wiley   +1 more source

Recent findings on subjective well‐being and physical, psychiatric, and social comorbidities in individuals with schizophrenia: A literature review

Neuropsychopharmacology Reports, Volume 42, Issue 4, Page 430-436, December 2022., 2022
Abstract Aim Care for people with schizophrenia is shifting the locus from long‐stay mental hospitals to nonspecialized community‐based settings. Knowledge on the care is not a sole property of psychiatric specialists. Community healthcare workers who do not specialize in psychiatry are recommended to learn more about schizophrenia.
Yupeng He, Ayako Tanaka, Taro Kishi, Yuanying Li, Masaaki Matsunaga, Shinichi Tanihara, Nakao Iwata, Atsuhiko Ota   +7 more
wiley   +1 more source

The prevalence of off-label use and supratherapeutic blood levels of outpatient psychotropic medication in suicidal adolescents

Frontiers in Psychiatry
IntroductionAdolescents with mental disorders show an increased risk of suicidal phenomena. Vice versa, suicidality is a serious adverse event of psychotropic drug therapy in adolescents.
Isabel Hach, Thomas Bertsch, Patrick Nonell   +2 more
doaj   +1 more source

Metabolism study of 3‐chloromethcathinone (3‐CMC) by dried blood spot (DBS) sampling after controlled administration using a murine model

Drug Testing and Analysis, EarlyView.
The metabolism of 3‐chloromethcathinone (3‐CMC) was studied after controlled administration in a murine model using the dried blood spot (DBS) technique for the sampling, storage and purification of blood samples. The metabolite profile of 3‐CMC was studied by LC‐HRMS, while the stability of 3‐CMC and its three identified metabolites was also assessed ...
Serena Mestria, Sara Odoardi, Valeria Valentini, Giorgia Corli, Marta Bassi, Matteo Marti, Sabina Strano‐Rossi   +6 more
wiley   +1 more source

Caffeine facilitates extinction of auditory fear conditioning in rats

Neuropsychopharmacology Reports, Volume 42, Issue 4, Page 521-525, December 2022., 2022
Abstract Caffeine is the most widely consumed psychostimulant drug which could affect learning and memory acting through central adenosine receptors. Although caffeine has been suggested to impair the acquisition and the expression of auditory fear conditioning, its effect on the extinction has not been elucidated. To address this issue, in the present
Takaaki Ozawa, Kodai Kaseda, Yukio Ichitani, Kazuo Yamada   +3 more
wiley   +1 more source

Human phase‐I metabolism of three synthetic cannabinoids bearing a cumyl moiety and a cyclobutyl methyl or norbornyl methyl tail: Cumyl‐CBMEGACLONE, Cumyl‐NBMEGACLONE, and Cumyl‐NBMINACA

Drug Testing and Analysis, EarlyView.
The human phase‐I metabolism of three SCRAs bearing a cumyl moiety and a CBM or NBM tail, based on LC‐qToF‐MS data of authentic urine specimens. Abstract Synthetic cannabinoid receptor agonists (SCRAs) continue to show high prevalence on the new psychoactive substances drug market.
Arianna Giorgetti, Pietro Brunetti, Belal Haschimi, Benedikt Pulver, Jennifer Paola Pascali, Jan Riedel, Volker Auwärter   +6 more
wiley   +1 more source