Results 51 to 60 of about 43,186 (297)

Remimazolam Ameliorates Autistic‐Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD

Advanced Science, EarlyView.
The ultra‐short‐acting sedative remimazolam has a sustained therapeutic effect on the core symptoms of VPA‐exposed mice. Remimazolam, a GABA agonist, exerts its therapeutic effects by protecting dopamine neurons in the VTA of VPA‐exposed mice. Meanwhile, ferroptosis is the critical mechanism by which remimazolam protects VTA dopaminergic neurons and ...
Yuxin Zhang, Jianwei Lin, Chaoyang Tong, Xin Fu, Mengqin Shan, Yue Huang, Kan Zhang, Jijian Zheng   +7 more
wiley   +1 more source

Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression

Advanced Science, EarlyView.
This study identifies elevated taurocholic acid (TCA) in Major Depressive Disorder patients. Gut microbiome‐associated TCA impairs hippocampal neurogenesis, triggers microglia activation, and elicits depression‐like behavior in mice via the S1PR2. In patients, functional neuroimaging reveals that serum TCA levels correlate with altered functional ...
Xiaoying Cai, Taipeng Sun, Mengzhen Feng, Gang Chen, Junchi Zhou, Hong Zhuang, Dan Wang, Ying Chen, Zhen Cheng, Zhi Xu, Xiao Zheng, Xueli Zhang, Yonggui Yuan   +12 more
wiley   +1 more source

Light Therapy Alleviates Addiction‐Related Symptoms and Reshapes Habenula and Midbrain Pathways

Advanced Science, EarlyView.
This study investigates light therapy for treating Internet Gaming Disorder (IGD). Functional MRI (fMRI) data reveal that light therapy enhances brain connectivity, particularly between the habenula and the medial orbitofrontal cortex (mOFC). These changes are associated with reduced withdrawal symptoms and addiction severity, highlighting the ...
Jinhui Li, Huiyang Huang, Cunhao Hu, Xuan Zhang, Song Lin, Xiaodan Huang, Ti‐fei Yuan, Kwok‐Fai So, Lu Huang, Chaoran Ren, Qian Tao   +10 more
wiley   +1 more source

Uncovering the Lipid Interface in Neurotransmission: Single Molecule Measurements of Neurotransmitters Interacting with Membranes Reveal Species Dependent Membrane Binding

Advanced Science, EarlyView.
Using single‐molecule whispering gallery mode sensors, neurotransmitter‐specific membrane binding signatures are measured that reveal intrinsically distinct interaction kinetics and orientations on a lipid membrane. Abstract Neurotransmitters (NTs) have traditionally been understood to act via aqueous‐phase receptor binding, but growing evidence ...
Thomas L. Derrien, Aneeth Kakkanattu Arunkumar, Rosalind Cross, Emilie Sunnucks, Frank Vollmer   +4 more
wiley   +1 more source

The overprescription of antidepressants and its impact on the elderly in Australia

Trends in Psychiatry and Psychotherapy, 2018
Introduction Psychopharmaceutical medications are noted for being one of the most commonly prescribed drugs worldwide, which makes the issue of overprescribing them such a heated topic in medicine and psychiatry today.
Muath Alduhishy
doaj   +1 more source

Appropriateness of psychotropic medication use in a cohort of adolescents with intellectual disability in Queensland, Australia

BJPsych Open, 2020
Background Psychotropic medications are sometimes used off-label and inappropriately. This may cause harm to adolescents with intellectual disability. However, few studies have analysed off-label or inappropriate prescribing to this group.
Menghuan Song, Robert S. Ware, Tan N. Doan, Lyn McPherson, Julian N. Trollor, David Harley   +5 more
doaj   +1 more source

Effectiveness of Pre‐Transplant Dual GLP‐1 Receptor Agonist and SGLT2 Inhibitor Therapy on All‐Cause Mortality in Organ Transplantation Candidates with Obesity and Type 2 Diabetes: a Target‐Trial Emulation

Advanced Science, EarlyView.
This target trial emulation in solid organ transplant candidates with obesity and type 2 diabetes evaluates whether pre‐transplant dual therapy with GLP‐1 receptor agonists plus SGLT2 inhibitors is associated with post‐transplant mortality and kidney graft outcomes compared with monotherapy or usual care, using multinational electronic health records ...
Yu‐Nan Huang, Min‐Yu Tsou, Pin‐Hung Li, Jo‐Ching Chen, Yen‐Liang Liu, Gideon Meyerowitz‐Katz, Tsung‐Hsun Tsai, Pen‐Hua Su   +7 more
wiley   +1 more source

A NARRATIVE REVIEW OF ADVANCES IN PHARMACOGENETICS AND PERSONALIZED MEDICINE IN PSYCHIATRY.

Student's Journal of Health Research Africa, 2023
The variable effectiveness and side effects demonstrated in patients who receive psychotropic drugs show that there is a need for developing personalized medicines in psychiatry.
Dr. Farheen fatma, Dr.Dhruv
doaj   +1 more source

Attitudes Toward Psychological Disorders and Alternative Medicine in Saudi Participants

Frontiers in Psychiatry, 2021
Background: This study was designed to investigate Saudis' attitudes toward mental distress and psychotropic medication, attribution of causes, expected side effects, and to analyze participants' expectations toward alternative or complementary medicine ...
Mohamed H. Alegiry, Nahid H. Hajrah, Nada A. Y Alzahrani, Hossam H. Shawki, Hossam H. Shawki, Muhammadh Khan, Muhammadh Khan, Houda Zrelli, Houda Zrelli, Ahmed Atef, Youngil Kim, Ibrahim A. Alsafari, Leila Arfaoui, Hesham F. Alharby, Abdulrahman S. Hajar, Hesham El-Seedi, Lekh Raj Juneja, Jamal S. M. Sabir, Jamal S. M. Sabir, Abdelfatteh El Omri, Abdelfatteh El Omri   +20 more
doaj   +1 more source

[Psychotropic agents in emergency medicine].

Medizinische Klinik, Intensivmedizin und Notfallmedizin, 2015
The aim of these two CME articles Psychotropic agents in emergency medicine and Psychopharmacotherapy in emergency medicine is to give an overview of drugs and their indications in the context of emergency psychiatry. Most relevant for prehospital care are benzodiazepines and antipsychotics, like lorazepam, diazepam, and haloperidol.
Wolf, A., Mueller, M. J., Pajonk, F.-G. B.   +2 more
openaire   +3 more sources