Results 71 to 80 of about 30,623 (153)
PTCH1 mutations' role in keratocystic odontogenic tumors and nevoid basal cell carcinoma syndrome
Oral Oncology ReportsNevoid basal cell carcinoma syndrome (NBCCS) is a typical autosomal dominant disorder distinguished by malformations in development and an increased susceptibility to cancer.
Archana Behera +1 more
doaj +1 more source
Nos2 deficiency increases the incidence of MB in Ptch1+/− mice.
, 2012 (A) Kaplan-Meier analysis of MB incidence in 215 Ptch1+/− Nos2+/+ mice (orange line) versus 221 Ptch1+/− Nos2−/− mice (red line). Ptch1+/− Nos2−/− mice demonstrated an approximately two-fold increase in MB incidence (p = 0.0007, Logrank test).
Daniel Haag (177450) +11 more
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Numb positively regulates Hedgehog signaling at the ciliary pocket
Nature CommunicationsHedgehog (Hh) signaling relies on the primary cilium, a cell surface organelle that serves as a signaling hub for the cell. Using proximity labeling and quantitative proteomics, we identify Numb as a ciliary protein that positively regulates Hh signaling.
Xiaoliang Liu +16 more
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Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms. [PDF]
, 2015 In the vertebrate neural tube, the morphogen Sonic Hedgehog (Shh) establishes a characteristic pattern of gene expression. Here we quantify the Shh gradient in the developing mouse neural tube and show that while the amplitude of the gradient increases ...
Page, KM +6 more
core
, 2015 Glioblastoma Multiforme (GBM), the most common and lethal adult primary tumor of the brain, showed a link between Sonic Hedgehog (SHH) pathway in the resistance to temozolomide (TMZ).
Munoz, Jessian L. +5 more
core +1 more source
CD antibody profiling of primary cells derived from Ptch1 deleted and wild type cerebella.
, 2019 CD antibody profiling of primary cells derived from Ptch1 deleted and wild type cerebella.
Marc Remke (3508145) +9 more
core +1 more source
Detection of PTCH1 Copy-Number Variants in Mosaic Basal Cell Nevus Syndrome
BiomedicinesBasal cell nevus syndrome (BCNS) is an inherited disorder characterized mainly by the development of basal cell carcinomas (BCCs) at an early age. BCNS is caused by heterozygous small-nucleotide variants (SNVs) and copy-number variants (CNVs) in the ...
Guido M. J. M. Roemen +9 more
doaj +1 more source
IHC analysis showing dual SHH/α-ACTIN, SHH/CD31, PTCH1/α-ACTIN, and PTCH1/CD31.
, 2013 SHH and PTCH1 co-localize with α-ACTIN in smooth muscle but were not present in the endothelium. Light blue staining is unavoidable auto-fluorescence present in human penis and dark bluish-purple represents α-ACTIN and CD31 proteins.
Nicholas L. Angeloni (445766) +3 more
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The expression patterns of Shh, Ptch1, Foxa2 and Gata3 in E11.5 mouse brain from ABA.
, 2014 Red colors ranging from light to dark indicate the gene expression intensities ranging from low to high. The expression patterns of Shh and Ptch1 defined two adjacent non-overlapping brain domains: Shh+Ptch1− domain and Shh−Ptch1+ domain as shown in ...
Jinhua Liu (189844) +5 more
core +1 more source
Ptch1 is essential for cochlear marginal cell differentiation and stria vascularis formation
Summary: A common cause of deafness in humans is dysregulation of the endocochlear potential generated by the stria vascularis (SV). Thus, proper formation of the SV is critical for hearing. Using single-cell transcriptomics and a series of Shh signaling
Karl Kam Hei So +3 more
core +1 more source