Results 11 to 20 of about 9,548 (210)

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Acacetin Alleviates Loperamide-Induced Functional Constipation by Inhibiting P53-Mediated Apoptosis in Colonic Epithelial Cells. [PDF]

Neurogastroenterol Motil
Acacetin, a compound from the traditional Chinese medicine Yunweiling, alleviates functional constipation by inhibiting P53‐mediated apoptosis in colonic epithelial cells. In mouse models and cell experiments, acacetin improved gastrointestinal motility and protected colon tissue by suppressing P53 activation and maintaining Akt1 signaling.
Chen X, Yang T, Huang Y, Yang Y, Li X, Ma Y, Long H, Liao D, Zhang P, Wen W.   +9 more
europepmc   +2 more sources

US Features of the Parathyroid Glands: An Intraoperative Surgical Specimen Study

Journal of the Korean Society of Radiology, 2023
Purpose This study aimed to evaluate the US features of the parathyroid glands (PTGs) using surgical specimens of normal PTGs obtained during thyroid surgery.
Wooyul Paik, Jong Cheol Lee, Byeong-Joo Noh, Dong Gyu Na   +3 more
doaj   +1 more source

Statin-induced myopathic changes in primary human muscle cells and reversal by a prostaglandin F2 alpha analogue [PDF]

, 2020
Statin-related muscle side effects are a constant healthcare problem since patient compliance is dependent on side effects. Statins reduce plasma cholesterol levels and can prevent secondary cardiovascular diseases.
Dittmar, Gunnar, Grieben, Ulrike, Grunwald, Stefanie Anke, Haafke, Stefanie, Jedraszczak, Nicole, Kress, Wolfram, Patone, Giannino, Popp, Oliver, Saar, Kathrin, Spuler, Simone, Steinhagen-Thiessen, Elisabeth   +10 more
core   +1 more source

Scheduling in Heterogeneous Distributed Computing Systems Based on Internal Structure of Parallel Tasks Graphs with Meta-Heuristics

Applied Sciences, 2020
The problem of scheduling parallel tasks graphs (PTGs) represented by directed acyclic graphs (DAGs) in heterogeneous distributed computing systems (HDCSs) is considered an nondeterministic polynomial time (NP) problem due to the diversity of ...
Apolinar Velarde Martinez
doaj   +1 more source

Time-delayed model of immune response in plants [PDF]

, 2015
In the studies of plant infections, the plant immune response is known to play an essential role. In this paper we derive and analyse a new mathematical model of plant immune response with particular account for post-transcriptional gene silencing (PTGS).
Al-Taleb, Beretta, Beretta, Berger, Bergstrom, Bernstein, Blyuss, Blyuss, Breda, Burgyán, Campbell, Chan, Costa, Cuccato, De Lenheer, Ehness, Escobar, Fritig, G. Neofytou, Gergerich, Gourley, Groenenboom, Gu, Hammond, Himber, Jeger, Jones, K.B. Blyuss, Liang, Llave, McCluskey, Melnyk, Mitsuhara, Molnar, Perelson, Purcell, Raab, Raja, Roberts, Rojas, Roth, Ruan, Schultz, Smith, Smith, Sonoda, Strange, Taşkin, Tenllado, Tilman, van den Bosch, Vaucheret, Wassenegger, Waterhouse, Waterhouse, Y.N. Kyrychko, Yuan, Zhang, Zhang, Zhang, Zhang, Zhang, Zvereva   +62 more
core   +2 more sources

Investigation of the effects of P1 on HC-pro-mediated gene silencing suppression through genetics and omics approaches

Botanical Studies, 2020
Background Posttranscriptional gene silencing (PTGS) is one of the most important mechanisms for plants during viral infection. However, viruses have also developed viral suppressors to negatively control PTGS by inhibiting microRNA (miRNA) and short ...
Sin-Fen Hu, Wei-Lun Wei, Syuan-Fei Hong, Ru-Ying Fang, Hsin-Yi Wu, Pin-Chun Lin, Neda Sanobar, Hsin-Ping Wang, Margo Sulistio, Chun-Ta Wu, Hsiao-Feng Lo, Shih-Shun Lin   +11 more
doaj   +1 more source

TYMV and TRV infect Arabidopsis thaliana by expressing weak suppressors of RNA silencing and inducing host RNASE THREE LIKE1.

PLoS Pathogens, 2023
Post-Transcriptional Gene Silencing (PTGS) is a defense mechanism that targets invading nucleic acids of endogenous (transposons) or exogenous (pathogens, transgenes) origins.
Hayat Sehki, Agnès Yu, Taline Elmayan, Hervé Vaucheret   +3 more
doaj   +1 more source

Nucleotide bias of DCL and AGO in plant anti-virus gene silencing [PDF]

, 2010
Plant Dicer-like (DCL) and Argonaute (AGO) are the key enzymes involved in anti-virus post-transcriptional gene silencing (AV-PTGS). Here we show that AV-PTGS exhibited nucleotide preference by calculating a relative AV-PTGS efficiency on processing ...
Dalmay, Tamas, Ho, Thien, Huang, Linfeng, Li, Zhigang, Ohshima, Kazusato, Pallett, Denise W., Walsh, John A., Wang, Hui, Wang, Liang   +8 more
core   +1 more source

RDR2 partially antagonizes the production of RDR6-dependent siRNA in sense transgene-mediated PTGS.

PLoS ONE, 2012
BackgroundRNA-DEPENDENT RNA POLYMERASE6 (RDR6) and SUPPRESSOR of GENE SILENCING 3 (SGS3) are required for DNA methylation and post-transcriptional gene silencing (PTGS) mediated by 21-nt siRNAs produced by sense transgenes (S-PTGS).
Vincent Jauvion, Maud Rivard, Nathalie Bouteiller, Taline Elmayan, Hervé Vaucheret   +4 more
doaj   +1 more source