Results 291 to 300 of about 196,863 (319)
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Comprehensive Physiology, 2016
ABSTRACTPTH and Vitamin D are two major regulators of mineral metabolism. They play critical roles in the maintenance of calcium and phosphate homeostasis as well as the development and maintenance of bone health. PTH and Vitamin D form a tightly controlled feedback cycle, PTH being a major stimulator of vitamin D synthesis in the kidney while vitamin ...
Syed Jalal, Khundmiri +2 more
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ABSTRACTPTH and Vitamin D are two major regulators of mineral metabolism. They play critical roles in the maintenance of calcium and phosphate homeostasis as well as the development and maintenance of bone health. PTH and Vitamin D form a tightly controlled feedback cycle, PTH being a major stimulator of vitamin D synthesis in the kidney while vitamin ...
Syed Jalal, Khundmiri +2 more
openaire +2 more sources
Endocrinology, 1994
Recent data have shown that PTH down-regulation of its receptor on opossum kidney (OK) cells is not associated with any change in the steady state level of the PTH/PTH-related peptide (PTHrP) receptor messenger RNA. For analysis of down-regulation of the PTH/PTHrP receptor in OK cells, the present work uses a specific receptor anti-serum, SR-2, that is
A B, Abou-Samra +5 more
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Recent data have shown that PTH down-regulation of its receptor on opossum kidney (OK) cells is not associated with any change in the steady state level of the PTH/PTH-related peptide (PTHrP) receptor messenger RNA. For analysis of down-regulation of the PTH/PTHrP receptor in OK cells, the present work uses a specific receptor anti-serum, SR-2, that is
A B, Abou-Samra +5 more
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PTH(1–84)/PTH(7–84): a balance of power
American Journal of Physiology-Renal Physiology, 2006This review considers many new basic and clinical aspects of parathyroid hormone (PTH). We focus especially on the identification of PTH fragments and how they may relate to renal failure, diagnosis, and treatment of secondary hyperparathyroidism and renal osteodystrophy.
Peter A, Friedman, William G, Goodman
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PTH Receptors and Skeletal Resistance to PTH Action
2020Secondary hyperparathyroidism (SHPT) is an integral component of chronic kidney disease-mineral and bone disorder (CKD-MBD). Many factors have been associated with its development and progression, but the presence of skeletal or calcemic resistance to the action of PTH in CKD has often gone unnoticed.
Jordi Bover +5 more
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Journal of endocrinological investigation, 2012
At least 2 different types of cells, hematopoietic and mesenchymal, are present in the adult bone marrow, in addition to endothelial cells. Hematopoietic and mesenchymal cells are believed to originate from hematopoietic stem cells (HSC) and mesenchymal stem cells (MSC), respectively.
M. Ohishi, E. Schipani
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At least 2 different types of cells, hematopoietic and mesenchymal, are present in the adult bone marrow, in addition to endothelial cells. Hematopoietic and mesenchymal cells are believed to originate from hematopoietic stem cells (HSC) and mesenchymal stem cells (MSC), respectively.
M. Ohishi, E. Schipani
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PTHrP, PTH, and the PTH/PTHrP receptor in endochondral bone development
Birth Defects Research Part C: Embryo Today: Reviews, 2003AbstractEndochondral bone development is a fascinating story of proliferation, maturation, and death. An understanding of this process at the molecular level is emerging. In particular, significant advances have been made in understanding the role of parathyroid‐hormone‐related peptide (PTHrP), parathyroid hormone (PTH), and the PTH/PTHrP receptor in ...
Ernestina, Schipani, Sylvain, Provot
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PTH spikes during parathyroid exploration—a possible pitfall during PTH monitoring?
Langenbeck's Archives of Surgery, 2006Parathyroid hormone (PTH) spikes caused by unintentional manipulation of the hypersecreting glands may lead to interpretation problems in intraoperative PTH monitoring. Their frequency and surgical consequences were evaluated.Intraoperative PTH values of 401 patients with primary hyperparathyroidism and single gland disease were analysed. Patients were
Philipp, Riss +3 more
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Conformational studies of parathyroid hormone (PTH)/PTH-related protein (PTHrp) chimeric peptides
Biopolymers, 2000The N-terminal 1-34 segments of both parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP) bind and activate the same membrane-embedded G protein-coupled receptor (PTH1 Rc) present on the surface of cells in target tissues such as bone and kidney.
SCHIEVANO, ELISABETTA +6 more
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2004
The present invention relates to peptides that are parathyroid hormone (PTH) analogs, useful for the treatment of hypoparathyroidism and diseases characterized by bone mass reduction, such as osteoporosis, and for stimulating bone repair or favoring the engraftment of a bone implant; to the pharmaceutical compositions comprising these PTH-like peptides
CAPORALE, ANDREA +6 more
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The present invention relates to peptides that are parathyroid hormone (PTH) analogs, useful for the treatment of hypoparathyroidism and diseases characterized by bone mass reduction, such as osteoporosis, and for stimulating bone repair or favoring the engraftment of a bone implant; to the pharmaceutical compositions comprising these PTH-like peptides
CAPORALE, ANDREA +6 more
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Kinetics of PTH Metabolism and PTH Fragments in Chronic Renal Failure
2015Distribution and metabolic degradation of bPTH was studied in man after infusion of 400 U bPTH and blood sampling up to 2h. Disappearance rates of intact 1-84 bPTH, carboxyl- and amino-regional peptides were calculated for healthy subjects (n = 12); patients suffering from moderate (GFR 15--30 ml/min, n = 4) and advanced (GFR less than or equal to 10 ...
N, Lustenberger +4 more
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