Results 111 to 120 of about 92,645 (204)

Current and Emerging Pharmacologic Therapies for Diabetic Retinopathy

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 3, March 2026.
ABSTRACT Diabetic retinopathy, a prevalent microvascular complication of diabetes mellitus, is a leading cause of blindness among adults in developed countries. Risk factors include prolonged duration of diabetes, elevated glycosylated hemoglobin levels, hypertension, and dyslipidemia, with rapid glucose reduction also increasing risk for developing ...
Jennifer N. Clements, Julia Mesawich, Cassandra Twisdale   +2 more
wiley   +1 more source

Lead‐Free Sb–Bi Perovskite‐Inspired Memristors: Compositional Control of Vacancy Migration for Neuromorphic Computing

Small Structures, Volume 7, Issue 3, March 2026.
Composition engineering of Sb–Bi‐based systems enables tunable ionic conduction and stable, lead‐free memristors. The interplay between capacitive and inductive processes gives rise to strong synaptic functionalities, highlighting their potential for emerging neuromorphic computing applications.
Ramesh Kumar, Noora Lamminen, Aman Ghadge, Monojit Bag, G. Krishnamurthy Grandhi, Paola Vivo   +5 more
wiley   +1 more source

Enzyme‐Powered DNA Origami Nanostructures for Enhanced Mucosal Diffusion

Small Structures, Volume 7, Issue 3, March 2026.
Single‐particle tracking reveals how DNA origami navigates mucus. Bare structures show limited diffusion, while enzyme‐functionalized nanostructures exhibit enhanced mobility. Symmetrically arranged urease creates uniform pH gradients for smooth propulsion, whereas asymmetrically placed catalase drives bubble‐mediated motion.
Matteo Tollemeto, Emily Tsang, Lars J. M. M. Paffen, Lasse H. E. Thamdrup, Jan van Hest, Tania Patiño Padial, Kurt V. Gothelf, Anja Boisen   +7 more
wiley   +1 more source

Targeting MCL‐1 and MAPK overcomes venetoclax resistance in FLT3‐ITD‐positive AML cells harbouring activating PTPN11 (SHP‐2) mutations

British Journal of Haematology, Volume 208, Issue 3, Page 905-915, March 2026.
Summary Venetoclax (VEN)‐based therapies have improved the treatment of acute myeloid leukaemia (AML); however, the emergence of resistance remains a major limitation. Mutations in protein tyrosine phosphatase (PTP) non‐receptor type 11 (PTPN11) and FMS like tyrosine kinase 3 with internal tandem duplication (FLT3‐ITD) are common in resistant patients ...
Maximilian Fleischmann, Ole Hansen, Diana Voigtländer, Julia Bechwar, Lenny‐Joseph Schwietzer, Sanja Bahr, Ulf Schnetzke, Mike Fischer, Florian H. Heidel, Tina M. Schnöder, Jörg P. Müller, Andreas Hochhaus, Sebastian Scholl   +12 more
wiley   +1 more source

Transforming cisplatin into targeted photothermal chemotherapeutics through the platinum-phosphate coordination within a hyaluronan nanogel. [PDF]

Sci Adv
Zhang Y, Wang H, Guo H, Gou X, Hao X, Li J, Deng H, Zhang W.   +7 more
europepmc   +1 more source

Protein tyrosine phosphatases as emerging targets for cancer immunotherapy

British Journal of Pharmacology, Volume 183, Issue 6, Page 1233-1249, March 2026.
Abstract Contemporary strategies in cancer immunotherapy, despite remarkable success, remain constrained by inherent limitations such as suboptimal patient responses, the emergence of drug resistance, and the manifestation of pronounced adverse effects. Consequently, the need for alternative strategies for immunotherapy becomes clear.
Zihan Qu, Jiajun Dong, Zhong‐Yin Zhang
wiley   +1 more source

Validity of the 2019 European Society of Cardiology Pre-Test Probability (2019 ESC-PTP) for predicting obstructive coronary artery disease among Malaysians. [PDF]

Sci Rep
Mohammad Rafee MA, Ibrahim KS, Kadir RFA, Mohamed-Yassin MS, Baharudin N.   +4 more
europepmc   +1 more source

Leishmania donovani's protein tyrosine phosphatases interact with DUF21 and respond to environmental magnesium

The FEBS Journal, Volume 293, Issue 6, Page 1754-1770, March 2026.
The Leishmania phosphatase PTP1, and possibly the genetically similar PTP2, interacts with the Leishmania transmembrane protein DUF21. When both ptp1 and ptp2 are knocked out of Leishmania (LdΔPTP1/2), the parasite can no longer survive without magnesium in vitro and has reduced viability in the host macrophage. Conversely, in duf21 knockout (LdΔDUF21),
Kayla Paulini, Hira Khursheed, Wen Wei Zhang, Isabelle Aubry, Greg Matlashewski, Michel L. Tremblay, Patrick Lypaczewski   +6 more
wiley   +1 more source

Microneedle-delivered ROS-adaptive asiatic acid nanoparticles promote scarless repair via remodeling the pathological microenvironment. [PDF]

J Nanobiotechnology
Zhang Y, Tang X, Ma Y, Qiu Y, Wu X, Wu Y, Zeng L, Chen L, Wu H, Zheng Y, Xie J, Liang G, Yin L.   +12 more
europepmc   +1 more source

Wogonin Mitigates Depression by Inhibiting TNF‐α/TNFR1/CXCL1 Signalling‐Mediated Astrocyte Activation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 6, March 2026.
ABSTRACT Wogonin exhibits notable anti‐inflammatory and neuroprotective effects. Current study aimed to investigate the antidepressant potential of wogonin and its underlying mechanisms through in vitro and in vivo experiments. In vitro, wogonin attenuated lipopolysaccharide (LPS)‐induced astrocyte activation.
Huihui Chai, Kunying Zhao, Weiyan Hu, Bin Liu   +3 more
wiley   +1 more source