Results 141 to 150 of about 111,177 (248)

Preserved mitochondrial respiration in presence of oxidative stress and reduced mitochondrial mass after 10‐day bed rest in older adults

open access: yesThe Journal of Physiology, Volume 604, Issue 18, Page 7772-7798, 15 September 2026.
Abstract figure legend Ten older healthy male adults underwent 10 days of bed rest. Vastus lateralis muscle biopsies were collected at baseline (PRE) and after 10 days of bed rest (BR10), and mitochondrial adaptations were assessed using an integrative approach combining respirometry, protein analyses, RNA sequencing and transmission electron ...
Evgeniia Motanova   +16 more
wiley   +1 more source

Kinetic Compatibility as a Predictor of PTP1B Inhibitor Combination Outcomes: An Integrated Experimental and Computational Study

open access: yesChemMedChem, Volume 21, Issue 16, 27 August 2026.
Combining PTP1B inhibitors of distinct kinetic mechanisms determines their pharmacological outcome. Integrating enzyme kinetics, docking, molecular dynamics, and membrane‐permeability simulations, we show that mechanistically compatible pairs (competitive + competitive; uncompetitive + mixed) yield additivity, whereas competitive + uncompetitive ...
Jonathan Trapala   +7 more
wiley   +1 more source

Electro-mechanical risk score for coronary artery disease risk estimation using seismocardiography. [PDF]

open access: yesEur Heart J Digit Health
Dehkordi P   +11 more
europepmc   +1 more source

Druggable genome CRISPRi screen in hydrogels reveals regulators of cortactin-driven actin remodeling promoting glioblastoma invasion. [PDF]

open access: yesJCI Insight
Hu M   +16 more
europepmc   +1 more source

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