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Disturbances of Puberty

Clinics in Obstetrics and Gynaecology, 1985
The initiation and progress of puberty requires progressive pulsatile stimulation of the pituitary by GnRH and of the gonads by LH and FSH. Gonadal maturation continues throughout childhood and is not confined to puberty. We have discussed the events of normal puberty and emphasized the consonance of the acquisition of different components of sexual ...
R, Stanhope, J, Adams, C G, Brook
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Delayed puberty

Best Practice & Research Clinical Endocrinology & Metabolism, 2002
Puberty is the acquisition of secondary sexual characteristics associated with a growth spurt and resulting in the attainment of reproductive function. Delayed puberty is diagnosed when there is no breast development by 13.4 years of age in a girl and no testicular enlargement by 14.0 years in a boy. The aetiologies are: (i) pubertal delay, either with
Cristina, Traggiai, Richard, Stanhope
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Precocious Puberty

The Indian Journal of Pediatrics, 1997
Puberty occurring before the age of 8 years in girls and 9 years in boys in considered precocious. The numerous causes of precocity can be classified as central or peripheral. Central or true precocious puberty (CPP) is due to premature activation of the hypothalamopituitary-gonadal axis and is isosexual.
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Androgens and Puberty

Best Practice & Research Clinical Endocrinology & Metabolism, 2002
Puberty is associated with an increasing production of androgenic steroids. Adrenal androgen formation, termed adrenarche, may precede gonadal testosterone synthesis. Both adrenal and gonadal androgens exert their biological effects via the androgen receptor, a nuclear transcription factor modulating a specific transcription regulation of largely ...
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Delayed puberty

Minerva Pediatrica, 2021
The onset of puberty may be late - in the latter part of the predicted normal range or truly delayed - beyond this range. The latest age to start is usually regarded as 13 years in girls and 14 years in boys. There may also be a delayed completion of puberty, 16 years in girls and 17 years in boys.
Gary, Butler, Preetha, Purushothaman
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Regulation of puberty

Best Practice & Research Clinical Endocrinology & Metabolism, 2002
Pubertal development is the last phase of a continuum of changing gonadotrophin releasing hormone (GnRH) activities. Whether or not puberty tends to start at a younger age, as has been recently described in a population of black Americans, remains under debate. Such early onset has not been confirmed in different European countries.
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Puberty

2007
Puberty consists of interrelated biological changes and occurs at a time when the individual also encounters cognitive and social changes. In this article we examine our current knowledge regarding the onset of puberty, the sequence and timing of puberty, and medical issues and physiologic changes that may arise with pubertal maturation.
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ABERRANT PUBERTY

Obstetrics and Gynecology Clinics of North America, 1992
With the emergence of an understanding of the processes at the cellular level that control the differentiated functions of tissues and eventually manifest as the developmental sequence in the whole animal, it is possible to describe pubertal aberrations in terms that are at once grounded in fundamental concepts of cellular biology and of practical ...
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Physiology of Puberty

Hormone Research, 2008
Puberty is not a single event but one stage in development. The endocrine events of puberty in many ways recapitulate previous changes in the fetus. It is currently not known what triggers puberty at an appropriate time. It appears that puberty is restrained by higher central nervous system controls, but the restraint can be eliminated by injury or ...
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GPR54 and puberty

Trends in Endocrinology & Metabolism, 2004
At puberty, pulsatile secretion of hormones initiates sexual maturation of the gonads. The G-protein-coupled receptor GPR54 is crucially involved in the initiation of puberty, along with its ligand metastin. Mice lacking GPR54 fail to undergo puberty and have immature reproductive organs and low levels of sex steroids and gonadotrophic hormones, but ...
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