Results 51 to 60 of about 414,762 (264)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Investigating the Greek general government accounting reform: The challenging task of staff training [PDF]

open access: yesContabilitate şi Informatică de Gestiune
Purpose – This article explores the status of public sector accounting education in Greece and assesses the readiness of the Greek general government financial employees to implement accrual accounting.
Michalis Bekiaris   +2 more
doaj   +1 more source

The Relationship between Perceived Justice in the Process of Human Resources Adjustment in Organization with Employees Feeling of Guilty [PDF]

open access: yesمطالعات مدیریت بهبود و تحول, 2019
At some points, organizations might have no choice but to attempt to adjust their staff and sack some. Obviously postponement or avoiding such layoffs in emergency times can be a serious threat to the whole well-being and survival of the business, but ...
Reza Vaezi   +2 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

A implementação do sistema de custos proposto pelo governo federal: uma análise sob a ótica institucional Aplicación del sistema de gastos del gobierno federal: un análisis según una lente institucional Implementing costs systems proposed by federal government: an analysis under a institutional lens

open access: yesRevista de Administração Pública, 2013
As informações sobre custos no setor público são importantes para uma análise adequada de eficiência e qualidade do gasto. Em países de referência a implementação dessa metodologia teve caráter mais abrangente, não focado apenas em questões técnicas.
Thiago Bernardo Borges   +2 more
doaj  

Organizational Black Hole Phenomenology: Politicization of Education System [PDF]

open access: yesفرایند مدیریت و توسعه, 2023
Purpose: The purpose of the current research was to investigate the nature of the black hole of politicization in the Education Ministry of Iran and to identify its causes and outcomes.
Mahdi Mohammadreza'i   +3 more
doaj  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Branding model of organizational leadership with employee experience management approach [PDF]

open access: yesمطالعات مدیریت بهبود و تحول
The aim of this research is to identify the effective factors on organizational leadership branding with the approach of employee experience management, which led to the design of a model in Iran's automotive research and development centers.
Davoud Hosseinpour   +3 more
doaj   +1 more source

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