Results 91 to 100 of about 7,445,022 (369)

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

The innovative development of urban space: the building in the Krymskiy Val

RUDN Journal of Public Administration, 2017
The object of the research of this work are the practices of the transforming of the urban environment into a common space comfortable and attractive for different groups of the population of Moscow.
I M Sakhno, A E Orlova
doaj   +1 more source

Behavioral Public Administration

, 2020
Behavioral public administration is an interdisciplinary research field that studies public administration topics by connecting insights from public administration with psychology and, more broadly, the behavioral sciences. Behavioral public administration scholars study important public problems such as discrimination, corruption, and burnout. Various
openaire   +2 more sources

Citizen Participation in Public Administration: Investigating Open Government for Social Innovation

R&D Management, 2019
In recent years, public sector organizations have increasingly focused on citizen contribution by adopting instruments known from open innovation. By collaborating with the periphery and leveraging external knowledge, government institutions initiate ...
Lisa Schmidthuber, F. Piller, M. Bogers, D. Hilgers   +3 more
semanticscholar   +1 more source

Germline variants in CDKN2A wild‐type melanoma prone families

Molecular Oncology, EarlyView.
Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen, Marie Loeng, Amalie Lund Holth, Per E. Lønning, Jürgen Geisler, Stian Knappskog   +5 more
wiley   +1 more source

Public–private partnership in Public Administration discipline: a literature review

, 2018
Public–private partnerships (PPPs) have become popular tools to deliver infrastructure and public services around the world. As an innovative public procurement approach, PPPs have drawn considerable attention from academic circles.
Huanming Wang, Weibo Xiong, Guangdong Wu, Dajian Zhu   +3 more
semanticscholar   +1 more source

The Living Lab as a Methodology for Public Administration Research: a Systematic Literature Review of its Applications in the Social Sciences

International Journal of Public Administration, 2019
Living labs have become a promising methodology for public administration research to design and study public innovations. Surprisingly, public administration research has paid scant attention to living labs to date.
R. Dekker, Juan Franco Contreras, A. Meijer   +2 more
semanticscholar   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Eye Tracking: Potential Applications for Public Management, Political Branding and Election Campaigns

RUDN Journal of Public Administration, 2020
The article analyzes potential of applying contemporary eye-tracking technologies in the areas of analytical support of political activities and public administration.
Yaroslav R. Ignatovskiy, Vladimir G. Ivanov   +1 more
doaj   +1 more source