Results 41 to 50 of about 10,277,087 (391)

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Beyond the State: Global Policy and Transnational Administration

International Review of Public Policy, 2019
The conceptual distance between the sovereign state and the global domain of policy making and administration is narrowing, challenging the prevailing methodological nationalism. The rise of global policy and transnational administration necessitates new
Kim Moloney, Diane Stone
doaj   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Virtual public administration: improving public administration procedures through project management [PDF]

, 2008
The best way to contribute electronic and mobile Government is by creating a public administration network in virtual communities. This is essentially the definition of Virtual Public Administration (VPA).
Kapogiannis, GT, Polychronakis, NE, Polychronakis, Y   +2 more
core  

Considerations on the Remuneration System of the Public Administration – an Analysis on Electoral Cycles and Scenarios Development [PDF]

Theoretical and Applied Economics, 2009
The paper aims to identify trends in the characteristics of the number of employees and the average salary in public administration in the last two election cycles in the period 2000-2008 compared with other sectors and proposes a series of three ...
Tudorel Andrei, Marius Profiroiu, Bogdan Oancea, Monica Nedelcu   +3 more
doaj   +1 more source

Teaching in uncertain times: The future of public administration education

Teaching Public Administration, 2020
The outbreak of severe acute respiratory syndrome coronavirus (SARS-CoV-2), and its resulting coronavirus disease 19 (COVID-19), needs no introduction.
Bruce D. McDonald
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Ethics of Public Administration in the Administration of Governance in Indonesia [PDF]

, 2018
Ethics is an important element which determines the successful implementation of organizations activities and public administration actors. The importance to implement public administration ethics in the Indonesia government bureaucracy was based to the ...
Nawawi, Z. (Zaidan)
core  

The perception of public servants about the practice of the principles LIMPE: a study at the University of Brasilia

Economia & Região, 2021
The aim of this paper is to seek evidence on the perception of public servants of the University of Brasilia regarding the practice of explicit constitutional principles of public administration in the caput of article 37 of the Federal Constitution ...
Alisson Assis de Lima, Luiz Honorato da Silva Júnior   +1 more
doaj  

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source