Results 171 to 180 of about 3,481,293 (343)

Editorial: One Step at a Time: Advances in Osteoarthritis

open access: yesFrontiers in Veterinary Science, 2021
Ali Mobasheri   +6 more
doaj   +1 more source

Achieving Optimal Health With Host‐Directed Therapies (HDTs) in Infectious Diseases—A New Horizon

open access: yesAdvanced Therapeutics, EarlyView.
Host‐directed therapies (HDTs) represent a transformative approach in infectious disease management by targeting host factors to enhance immune responses and inhibit viral replication. This innovative strategy leverages advanced genomics and gene editing technologies, offering promising avenues for improved patient outcomes and a new horizon in ...
Amol D. Gholap   +10 more
wiley   +1 more source

Clinically Relevant Metallic Nanoparticles in Tuberculosis Diagnosis and Therapy

open access: yesAdvanced Therapeutics, EarlyView.
Tuberculosis (TB) remains a global health challenge, with drug‐resistant strains exacerbating the issue. Metallic nanoparticles (MNPs) show promise in TB diagnosis as sensor probes and in combination therapy with antimycobacterial drugs, requiring further pre‐clinical and clinical research for clinical translation.
Christianah Aarinola Akinnawo   +1 more
wiley   +1 more source

Biomedical Application of Cold Plasma: Navigating Through Plasma Types and Devices by Antimicrobial Effectiveness and Tissue Tolerance

open access: yesAdvanced Therapeutics, EarlyView.
Cold plasma devices (J‐Plasma, Piezo Brush PZ3, Plasma Care) generate unique reactive species that penetrate tissues differently, enabling biofilm eradication while preserving tissue health. This study uncovers plasma‐device interactions with biofilms and surfaces, highlighting tailored applications for precision medicine and infection control ...
Thomas P. Thompson   +14 more
wiley   +1 more source

On the Relentless Pursuit of an Oral Insulin Delivery System: How Far is Too Far?

open access: yesAdvanced Therapeutics, EarlyView.
Injectable insulin preparations have far outpaced oral ones by virtue of adequate bioavailability and are driven by innovations, including insulin pumps, real‐time blood glucose monitoring, and artificial intelligence. In contrast, oral insulin delivery systems, including nanomedicines, continue to struggle and lag due to varied reasons.
Sourav Bhattacharjee
wiley   +1 more source

Insights into the Dynamics and Binding Mechanisms of the Alkhumra Virus NS2B/NS3 Protease: A Molecular Dynamics Study

open access: yesAdvanced Theory and Simulations, EarlyView.
The ΔRMSF$\Delta {\rm RMSF}$ analysis reveals significant flexibility differences between free NS3 and the NS2B/NS3 complex, with notable deviations in specific regions. Key residues driving NS2B binding are identified, and the protonation state of catalytic serine affects oxyanion hole formation.
Jurica Novak   +2 more
wiley   +1 more source

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