Results 171 to 180 of about 1,919,659 (338)

Physiological Considerations for Maximum Indoor Temperatures. [PDF]

J Physiol
Addison TEJ, Blake DM, Coleman P, Lock F, Loud E, Mackenzie A, Pande S, Tipton M.   +7 more
europepmc   +1 more source

NAD+‐Boosters Improve Mitochondria Quality Control In Parkinson's Disease Models Via Mitochondrial UPR

Advanced Science, EarlyView.
Treatment of MPTP‐incubated cells with NAD+‐boosters increase the UPRmt/mitophagy‐related mitochondria quality control (MQC). Disturbed plasma UPRmt‐mitophagy‐mediated MQC profiles in PD patient samples. NMN inhibits motor deficit and forestalls neuropathology phenotypes of PD mice, which is required the atf4‐medicated UPRmt pathway.
Shuoting Zhou, Xi Xiong, Jialong Hou, Qi Duan, Yi Zheng, Tao Jiang, Jiani Huang, Haijun He, Jiaxue Xu, Keke Chen, Wenwen Wang, Jinlai Cai, Jingjing Qian, Huijun Chen, Weihong Song, XinShi Wang, Chenglong Xie   +16 more
wiley   +1 more source

Editorial: One Step at a Time: Advances in Osteoarthritis

Frontiers in Veterinary Science, 2021
Ali Mobasheri, Ali Mobasheri, Ali Mobasheri, Ali Mobasheri, Ali Mobasheri, Troy N. Trumble, Christopher R. Byron   +6 more
doaj   +1 more source

Genetic Deconvolution of Embryonic and Maternal Cell‐Free DNA in Spent Culture Medium of Human Preimplantation Embryo Through Deep Learning

Advanced Science, EarlyView.
DECENT is a deep learning method that enhances noninvasive preimplantation genetic testing by accurately reconstructing embryonic copy number variations (CNVs) from cell‐free DNA in spent embryo culture media. By mitigating maternal contamination, DECENT improves diagnostic accuracy, even with high contamination levels, offering a reliable, noninvasive
Zhenyi Zhang, Jie Qiao, Yidong Chen, Peijie Zhou   +3 more
wiley   +1 more source

Preparedness and Response Considerations for High-Consequence Infectious Disease. [PDF]

Emerg Infect Dis
Chan J, Levine CB, Herstein JJ, Cloutier N, Sauer L, Mehta AK, Evans J, Basic and Translational State of the Science Working Group of the National Emerging Special Pathogens Training and Education Center’s Special Pathogens Research Network.   +7 more
europepmc   +1 more source

Prediction of Microstructural Representativity From A Single Image

Advanced Science, EarlyView.
Accurately estimating the reliability of phase fraction measurements from limited microstructural data remains a key challenge and is rarely reported for this reason. ImageRep addresses the problem by adapting the Two‐Point Correlation function to assess representativity from a single image.
Amir Dahari, Ronan Docherty, Steve Kench, Samuel J. Cooper   +3 more
wiley   +1 more source

Charting the future of PLOS Medicine: Priorities for evidence, impact, and equity. [PDF]

PLoS Med
Lumbard H, Baernighausen T.
europepmc   +1 more source

The man and the vision. Sir Dugald Baird: three decades of transforming work in reproductive health, [PDF]

, 2005
van Teijlingen, Edwin
core  

Disruption of ARID1B Recruitment to the Nuclear Pore Complex as a New Anticancer Therapeutic Strategy

Advanced Science, EarlyView.
This study identifies ARID1B as a chromatin‐bound driver of tumor growth in TNBC. ARID1B impairs ARID1A function and directly activates oncogenic programs through SWI/SNF remodeling. Its nuclear localization, mediated by the KPNA2–KPNB1–RANBP2 import machinery, is essential for its tumor‐promoting activity.
Olena Odnokoz, Anupam Banerjee, Xin Cui, Lidan Zeng, Amad Uddin, Christopher Li, Yueming Zhu, Mengyuan Zhang, Xiaodong Lu, Nagendra S. Yarla, Lu Wang, Jindan Yu, Jonathan C. Zhao, Ivet Bahar, Yong Wan   +14 more
wiley   +1 more source

Training in the speciality of General and Family Medicine in Angola: A cross-sectional study. [PDF]

Afr J Prim Health Care Fam Med
Da Silva Fernandes CTL, Da Mata Ferreira IN, Dos Santos MFD, Santos P.   +3 more
europepmc   +1 more source