Results 211 to 220 of about 4,518,842 (353)
hESCs‐derived Organoids Achieve Liver Zonation Features through LSEC Modulation
This article addresses the absence of zonation features in current organoid models by co‐culturing human embryonic stem cell‐derived hepatocytes with liver sinusoidal endothelial cells exhibiting distinct zonal characteristics. It demonstrates that differential WNT2 signaling from endothelial cells modulates hepatocyte zonation and metabolic functions,
Yuying Zhang+13 more
wiley +1 more source
Revisiting What Constitutes a Neglected Tropical Disease? [PDF]
Brindley PJ, Hotez PJ, Kamhawi S.
europepmc +1 more source
This work utilizes spatial transcriptomics to map the transcriptional landscape of adenomyosis with obvious invagination structure from the invaginating site to deep lesions. By integrating with single‐cell RNA sequencing, this study elucidates the molecular features of invagination, invasion, and fibrosis, and finds the major participants and vital ...
Boyu Li+19 more
wiley +1 more source
Enhancing patient satisfaction and experience through bedside interdisciplinary rounds: a quality improvement study. [PDF]
Ghali W+5 more
europepmc +1 more source
Human induced pluripotent stem cell‐derived retinal pigment epithelial (hiPSC‐RPE) cells, cultured on a clinically relevant PDLLA scaffold, are transplanted into immunosuppressed minipigs. The study demonstrates the viability, integration, and preservation of RPE‐specific features without gliosis or neuroinflammation, supporting their potential as a ...
Anna Macečková Brymová+27 more
wiley +1 more source
Polysubstance Use Is Not Synonymous With Poly Substance Use Disorder. [PDF]
Xu KY, Lin LA, Grucza RA.
europepmc +1 more source
Low‐Irradiance Antimicrobial Blue Light‐Bathing Therapy for Wound Infection Control
Antimicrobial blue light has been shown as an appealing non‐pharmacological antimicrobial alternative. However, its clinical applications have been hindered by high irradiance‐associated photothermal risks. In this work, a low‐irradiance blue light‐bathing concept and a wearable photonic wound patch are established to address this challenge in terms of
Jie Hui+12 more
wiley +1 more source
This work proposes a novel strategy targeting gut microbiota for managing polycystic ovary syndrome (PCOS). Inulin, a gut microbiota modulator, notably boosts the growth of short‐chain fatty acids (SCFAs)‐producers, represented by Bifidobacterium, thereby improving glucolipid metabolism and ovarian function of PCOS through suppressing the inflammatory ...
Lulu Geng+8 more
wiley +1 more source
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong+20 more
wiley +1 more source