Results 221 to 230 of about 4,570,917 (333)

Explainable Deep Multilevel Attention Learning for Predicting Protein Carbonylation Sites

open access: yesAdvanced Science, EarlyView.
Selective carbonylation sites (SCANS) are conceptualized, designed, evaluated, and released. SCANS captures segment‐level, protein‐level, and residue embeddings features. It utilizes elaborate loss function to penalize cross‐predictions at the residue level.
Jian Zhang   +6 more
wiley   +1 more source

The Impact of Social Work on the Management of Chronic Respiratory Diseases. [PDF]

open access: yesOpen Respir Arch
Gómez Pedrajas EM   +4 more
europepmc   +1 more source

Mechanical Load‐Induced Upregulation of Talin2 through Non‐Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis

open access: yesAdvanced Science, EarlyView.
Facet joint osteoarthritis (FJOA), prevalent in the elderly, involves Talin2 upregulation promoting ECM degradation while suppressing synthesis. Mechanical load stabilizes Talin2 via OTUB1‐mediated non‐canonical deubiquitination, driving CCL2 expression that recruits immune cells, exacerbating inflammatory joint degeneration.
Yizhen Huang   +11 more
wiley   +1 more source

Plasma DNMT1 Activity for Assessing Tumor Burden and Predicting Neoadjuvant Therapy Response in Breast Cancer

open access: yesAdvanced Science, EarlyView.
In this work, a detection method is presented for the activity of plasma DNA methyltransferase 1 (DNMT1), namely DNMT1 Identification by Variable Activity (DIVA). DIVA can detect plasma DNMT1 at levels as low as 10−7 U mL−1, also it successfully evaluated tumor burden and predicted the neoadjuvant therapy responses of breast cancer patients.
Yingran Wang   +10 more
wiley   +1 more source

Piezoresistive Effect: A New Concept for Hearing Aids

open access: yesAdvanced Science, EarlyView.
An MXene/PVA sound sensor utilizing piezoresistive effects has been proposed with a detection limit of 60 dB and a frequency response of 20–4000 Hz, which is comparable to the performance of commercial hearing aids. By combining the sensor with machine learning, the accuracy rate of voiceprint recognition of wildlife conservation can reach up to 99 ...
Mengyao Gao   +8 more
wiley   +1 more source

Nanogenerator Neuromodulation to Enable Locomotion Rehabilitation for Spinal Cord Injury via Epidural Electrical Stimulation

open access: yesAdvanced Science, EarlyView.
A hybrid nanogenerator (H‐NG) has been developed to be applied in epidural electrical stimulation (EES). Compared with a commercial stimulus generator (SG), the H‐NG can elicit hindlimb locomotion in rats with much lower electrical parameters and much smaller individual differences.
Cong Li   +12 more
wiley   +1 more source

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