Results 51 to 60 of about 2,567,640 (311)

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

The district operation centres in one of the largest local health authorities in Italy to manage COVID-19 surveillance and homecare: first implementation and results of a survey addressed to general practitioners

BMC Health Services Research, 2023
Background COVID-19 pandemic represented a shock for healthcare systems. Italy was one of the first country to deal with a huge number of patients to be diagnosed, isolated, and treated with scarce evidence-based guidelines and resources.
Emanuela Maria Frisicale, Andrea Barbara, Alessio Perilli, Elettra Carini, Adriano Grossi, Leonardo Simonetti, Giulia Tammam, Svetlana Axelrod, Angelo Tanese, Mauro Goletti, Paolo Parente   +10 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Challenges facing green space: is statute the answer? [PDF]

, 2019
Against a backdrop of austerity, characterised by public-sector funding cuts and a devolutionary agenda, this paper explores how legislation might address two, inter-related challenges which face public urban green space ('greenspace') in England and ...
Bennett, Ellen, Dickinson, Jill, Marson, James   +2 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Two-year retrospective review of costs associated with COVID-19 case management in Regina, Saskatchewan

Health Economics Review
Background The COVID-19 pandemic, declared in March 2020, caused significant morbidity and mortality globally. This study aims to estimate the costs associated with managing COVID-19 infected patients in Regina. Method The study focuses on the direct and
Olanrewaju Medu, Molly Trecker, Tania Diener, Maurice Hennink, Doug Coyle, Jessica Minion, Cara Benz, Amanda Lang, Maureen Anderson, Thomas Stewart, Tandi Steenkamp   +10 more
doaj   +1 more source

Moving Along the Learning Curve: From Values to Public Judgment: Citizen Dialogues on K-12 Education Reform [PDF]

, 2008
Based on dialogues with California's public, policy makers, and other stakeholders, assesses the public's priorities for K-12 reform and support for giving districts more authority and resources to meet state standards.
Heidi Gantwerk, Isabella Furth, Steven A. Rosell   +2 more
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

History Making: The Historian as Consultant

Public History Review, 2013
History is not just a genre of knowledge but also a basic feature of human life. Accounting for the past, or creating histories, to quote David Thelen, is ‘as natural a part of life as eating or breathing’.
Jorma Kalela
doaj   +3 more sources

A Kantian Conception of Free Speech [PDF]

, 2010
In this paper I provide an interpretation of Kant’s conception of free speech. Free speech is understood as the kind of speech that is constitutive of interaction respectful of everybody’s right to freedom, and it requires what we with John Rawls may ...
Varden, Helga
core   +1 more source