Results 61 to 70 of about 2,567,640 (311)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Anonymous and Adaptively Secure Revocable IBE with Constant Size Public Parameters [PDF]

, 2012
In Identity-Based Encryption (IBE) systems, key revocation is non-trivial. This is because a user's identity is itself a public key. Moreover, the private key corresponding to the identity needs to be obtained from a trusted key authority through an ...
Chen, Jie, Lim, Hoon Wei, Ling, San, Su, Le, Wang, Huaxiong   +4 more
core  

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Vaccination Coverages Among Splenectomized Patients: A Retrospective Study from an Italian Southern Province

Vaccines
Background: Splenectomized patients have a higher risk compared to the general population of developing post-splenectomy infection, particularly by capsulated bacteria.
Giuseppe Di Martino, Riccardo Mazzocca, Tania Masci, Lisa Berghella, Jacopo Del Papa, Francesco D’Aloisio, Mario Messinese, Fabrizio Cedrone, Patrizia Marani Toro, Graziella Soldato   +9 more
doaj   +1 more source

Health Care Opinion Leaders' Views on Health Reform [PDF]

, 2009
Presents results of a survey of healthcare experts on insurance, payment, and delivery system reforms, including a national insurance exchange with broad authority, a public plan option with a bundled payment system, and a standard benefits ...
Cathy Schoen, Karen Davis, Kristof Stremikis, Sara R. Collins   +3 more
core  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Herpes Zoster Vaccine Uptake and Active Campaign Impact, a Multicenter Retrospective Study in Italy

Vaccines
The Herpes Zoster (HZ) vaccination has proven both safe and effective in alleviating conditions related to HZ, leading to significant cost savings in national healthcare and social systems.
Andrea Ceccarelli, Federica Tamarri, Raffaella Angelini, Elizabeth Bakken, Ilaria Concari, Elsa Giannoccaro, Giada Domeniconi, Michela Morri, Chiara Reali, Francesca Righi, Silvia Serra, Gianmaria Semprini, Giulia Silvestrini, Valentina Turri, Davide Gori, Marco Montalti   +15 more
doaj   +1 more source

PENYELESAIAN KERUGIAN KEUANGAN NEGARA

Masalah-Masalah Hukum, 2010
In order to implement governance and development to realize people prosperity, Government us bestowedauthority to manage public finance. The authority is classified as administrative authority and treasuryauthority.
Henny Juliani
doaj   +1 more source

Assessing the Oral Health Needs of Public Housing Residents [PDF]

, 2011
Objectives: “Tooth Smart Healthy Start” is a randomized clinical trial which aims to reduce the incidence of early childhood caries (ECC) in Boston public housing residents as part of the NIH funded Northeast Center for Research to Evaluate and Eliminate
Garibyan, Ilya, Ghulam, Ayesha, Henshaw, Michelle   +2 more
core   +1 more source