Results 51 to 60 of about 228,162 (258)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Developing the Public Speaking Anxiety Scale (PSAS) for Adolescents: The Mediating Role of Dysfunctional Emotion Regulation in the Effect of Irrational Beliefs on Public Speaking Anxiety

Behavioral Sciences
Public speaking anxiety, which is closely related to social anxiety, is a crucial factor in the development of adolescents. It affects their ability to regulate their emotions and irrational beliefs, which in turn shapes their relationships and academic ...
Sezai Demir, Mustafa Onur Kan
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Perceived consequences of disseminating evidence on untreated recovery and moderate drinking after resolving alcohol concerns

Harm Reduction Journal
Aims There is substantial evidence that many people recover from serious alcohol concerns without treatment and further, return to moderate alcohol consumption.
John A. Cunningham
doaj   +1 more source

Can beliefs about musculoskeletal pain and work be changed at the national level? Prospective evaluation of the Danish national Job & Body campaign

Scandinavian Journal of Work, Environment & Health, 2018
OBJECTIVES: This study evaluates the Danish national Job & Body campaign on beliefs about musculoskeletal pain and work. METHODS: Initiated in 2011, a national campaign in Denmark targeted public sector employees with a mixture of networking activities ...
Lars L Andersen, Niels Geisle, Brian Knudsen   +2 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Neighborhood Conditions in a New Destination Context and Latine Youth’s Ethnic–Racial Identity: What’s Gender Got to Do with It?

Behavioral Sciences
This exploratory pilot study examined how Latine adolescents’ ethnic–racial identity (ERI)—specifically, centrality, private regard, and public regard—was shaped by parents’ gender role socialization (GRS) beliefs and perceptions of neighborhood ...
Olivia C. Goldstein, Dawn P. Witherspoon, Mayra Y. Bámaca   +2 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Sorcery and witchcraft beliefs on the front line of public health response in Papua New Guinea and beyond

Western Pacific Surveillance and Response
Problem: Many communities refer to sorcery or witchcraft to explain misfortunes such as sickness, death and disability. The effects of these beliefs on public health service delivery have long been overlooked.
Miranda Forsyth, Joanne Taylor, Tambri Housen, Celeste Marsh, Philip Gibbs, William Kipongi   +5 more
doaj   +1 more source