Results 41 to 50 of about 4,168,338 (311)

Foundation Facts & Figures Across the EU: Associating Private Wealth for Public Benefit [PDF]

, 2005
This leaflet provides a summary of key data from the EFC Research Task Force survey conducted in 2003/04 on the dimensions of the foundation sector in the European ...

core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Research ethics during infectious disease outbreaks: A survey of African research stakeholders using the Ebola virus disease outbreak as a case

Journal of Public Health in Africa, 2023
Conducting research during disease outbreaks can be ethically challenging as evidenced in the 2014‑2016 Ebola outbreak in West Africa and COVID‑19 pandemic.
Raji Tajudeen, Blessing Silaigwana, Alexei Yavlinsky, Sarah J.L. Edwards   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Public Benefit as Community Wellbeing in Archaeology

Internet Archaeology, 2021
This article outlines the theory and strategy behind Historic England's (HE) Wellbeing Strategy. It acknowledges the relevance of wellbeing to HE's core purpose, and proposes ways in which wellbeing can be built into archaeological and heritage projects.
Linda Monckton
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Evidencing and ensuring impactful research from developer-funded archaeology

Internet Archaeology
The developer-funded (or contracting) sector of the archaeological profession produces the vast majority of datasets from investigations across the UK, and the formally published outputs from these projects are acknowledged as being of an academic ...
Sadie Watson
doaj   +1 more source

Synergy and Group Size in Microbial Cooperation [PDF]

, 2012
Microbes produce many molecules that are important for their growth and development, and the consumption of these secretions by nonproducers has recently become an important paradigm in microbial social evolution.
Brannstrom, Ake, Brown, Sam P., Cornforth, Daniel M., Sumpter, David J. T.   +3 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Revisiting the relationship between the principle of benevolence and beneficence

Вестник Майкопского государственного технологического университета
The relevance of the research is substantiated by the fact that the principles of the educational process are almost always interconnected in their essence.
A. A. Stenishcheva
doaj   +1 more source