Results 101 to 110 of about 4,304,575 (311)

The MidSouth Partnership for Rural Community Colleges : building public policy while building rural communities [PDF]

Rural areas ; Rural ...
J. Charles Lee
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

The Histria Sud Sector. Recent Archaeological Research on an ‘Imposing’ Early Roman Public Building

Materiale și Cercetări Arheologice, 2014
In 1961, Nubar Hamparţumian resumed the archaeological research in the Basilica extra muros Sector at Histria. Among the discoveries made between 1961– 1964 were the ruins of an ‘ imposing’ Early Roman public building dated to the 3rd c. AD.
Dabîca, M.
doaj   +1 more source

Research and innovation in power electronics systems applied to energy management [PDF]

, 2008
The Power Electronics Systems Group (GSEP) at University Carlos III de Madrid (Spain) offers its wide experience and background in consultancy, R&D projects with private and public funding and pre-industrial prototype building in four main topics: energy
Barrado Bautista, Andrés
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

An Interpretable Modeling Method for Occupancy in Public Buildings Based on Typical Occupancy Data

Buildings
Occupancy, defined as the count of occupants, plays an important role in building design and operation stages. Obtaining reliable occupancy data for public buildings remains a challenging problem due to the lack of available on-site data.
Jiefan Gu, Yi Zhu, Ying Ji, Peng Xu, Linxue Li   +4 more
doaj   +1 more source

‘Sink or Swim’: A Qualitative Study to Understand How and Why Nurses Adapt to Support the Implementation of Integrated Diabetes Care

International Journal of Integrated Care, 2019
Background: Integrated care, organising care delivery within and between services, is an approach to improve the quality of care. Existing specialist roles have evolved to work across settings and services to integrate care.
Fiona Riordan, Niamh McGrath, Sean F. Dinneen, Patricia M. Kearney, Sheena M. McHugh   +4 more
doaj   +1 more source

Finding Meaning in the Flag: Contextualizing the Confederate Flag

, 2017
When I first learned about the removal of the Confederate flag from South Carolina’s state building in July of 2015, I was angry like many other people. For me, it wasn’t about the actual removal of the flag, but rather the arguments sparked around it. I
Ortman, Olivia J.
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Building Public Confidence: Ending Racial Profiling in Nebraska [PDF]

, 2014
The report reviewed data collected by the Nebraska Crime Commission. The ACLU's analysis of the data found that "profiling in Nebraska traffic stops disproportionately and negatively affects communities of colors." The ACLU report focuses on three ...

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Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source