Results 81 to 90 of about 14,528,667 (243)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Laying the Foundation for the Hensley Public Safety Building

, 1981
Cement + Products Corp. of Ellenton lays cement for what would be the Robert Hensley Public Safety Building, also known as the Manatee County ...

core  

Associations between indoor environmental parameters and occupant satisfaction: evidence from public buildings in Zhejiang, China

Journal of Asian Architecture and Building Engineering
The quality of indoor environment significantly impacts human health and satisfaction. However, the relationship between indoor environmental parameters and occupant satisfaction remains insufficiently explored. This study utilized the simultaneous point-
Jiantao Weng, Qiyuan Li, Yujie Zhao, Jingqi Zhao, Xuechen Gui, Xiaoyu Ying   +5 more
doaj   +1 more source

Evacuation Optimization Strategy for Large-Scale Public Building Considering Plane Partition and Multi-Floor Layout. [PDF]

Front Public Health, 2022
Fang H, Lv W, Cheng H, Li X, Yu B, Shen Z.   +5 more
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

The Histria Sud Sector. Recent Archaeological Research on an ‘Imposing’ Early Roman Public Building

Materiale și Cercetări Arheologice, 2014
In 1961, Nubar Hamparţumian resumed the archaeological research in the Basilica extra muros Sector at Histria. Among the discoveries made between 1961– 1964 were the ruins of an ‘ imposing’ Early Roman public building dated to the 3rd c. AD.
Dabîca, M.
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Bricks, Steel, and Education : The What and Why of the Portland School Building Program [PDF]

, 1959
This 30 page booklet describes the public school facilities renovation plan for Portland Public Schools, to be completed in 1960. At the time (1959) the money appropriated ($2,150,000) was the largest single appropriation for public school construction ...
School Building Committee, [Portland, Maine]
core  

Forecast of Electric Power Consumed by Public Buildings: Univariate and Multivariate Approaches Based on Quantile Regression Models

Energies
Load forecasting has become a key tool, especially for distribution system operators, to ensure optimal grid management and control. In recent years, attention has shifted toward probabilistic load forecasting (PLF), as it can model forecast uncertainty.
Sara Perna, Anna Rita Di Fazio, Andrea Iacovacci, Francesco Conte, Pasquale De Falco   +4 more
doaj   +1 more source