Results 91 to 100 of about 17,702,281 (301)
Mechanism choice can generally be described as the selection of some way to structure rules for social behavior. Nobel Laureate Eric Maskin recently described a mechanism as “an institution, procedure, or game for determining outcomes” (Maskin 2008: 568).
Richman, Barak D., Wiener, Jonathan B.
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Lua Nova: Revista de Cultura e Política, 2001 Analisa-se o modo como a ênfase da teoria da escolha pública na eficiência gerencial mediante o desenvolvimento da organização burocrática entra em conflito com a dimensão política da vida social, sobretudo na sua vertente democrática.
André Borges
doaj +1 more source
Impact of Local Public Services and Taxes on Dwelling Choice within a Single Taxing Jurisdiction: A Discrete Choice Model [PDF]
Discrete choice models of household location assume local public finance variables remain the same within a given taxing jurisdiction. Thus far, no such model has tested the validity of this assumption. This study employs McFadden’s (1978, 2001) discrete
Bulent Uyar, Kenneth H. Brown
core
Public Choice Theory and Legal Institutions
, 2017 This article asks what public choice can teach about legal institutions and their governing framework of public law. It begins with an overview and assessment of two important components of public choice: social choice theory (stemming from Arrow's ...
Daniel A. Farber
core +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Microeconomic Models of Overlapping Competing Jurisdictions (FOCJs)
Eesti Majanduspoliitilised Väitlused, 2017 One of the newer suggestions for the design of public economic units refers to Functional Overlapping Competing Jurisdictions (FOCJs), which are instruments to shape cooperation of jurisdictions, e.g. municipalities.
Mariia Chebotareva, Peter Friedrich
doaj +1 more source
Strategic Behavior in Contests: A Review of Dixit and Subsequent Commentaries
This study revisits the seminal proposition of strategic commitment in contest theory advanced by Avinash Dixit (1987) and provides a comprehensive review of strategic behavior in contests, focusing on the critical subsequent comments by Baik and Shogren
Korea Public Choice Association +1 more
core +1 more source