Results 51 to 60 of about 2,254,914 (312)
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Game theory approach to optimizing of public transport traffic under conditions of travel mode choice by passengers [PDF]
Transport Problems, 2014 Consideration was given to the problem of making decisions on public transport management. Three parties making decisions were marked out: passenger flow, transport operator and municipal authorities.
Mark KORYAGIN
doaj
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Современная наука и инновации, 2022 The paper examines the importance of the methodological debates of the 2010s, occurring in the study of electoral governance Until the mid-2000s subjectivist approach of the theory of rational choice almost unchallenged dominated in this scientific field
Nikolai Vladimirovich Grishin +1 more
doaj
THE ECONOMIC ROLE OF THE STATE IN THE NEW POLITICAL ECONOMY
Ekonomia i Prawo, 2006 The New Political Economy deals with human behaviour and responsiveness when it comes to the political aspects of public affairs. According to the New Political Economy all modern democratic tendencies create the foreground and make it possible for ...
Gabriela Przesławska
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
The two social philosophies of Ostroms' institutionalism [PDF]
The article argues that Ostroms’ institutionalism has a dimension that is complex and profound enough to deserve to be considered a “social theory” or a “social philosophy”.
Boettke, Peter
core +1 more source
Public choice theory and antitrust policy
Public Choice, 2009 We survey the pioneering contributions of Robert Tollison to the theory and practice of antitrust law enforcement. Inspired by his period of service during Ronald Reagan’s first administration as Director of the Federal Trade Commission’s Bureau of Economics, Tollison was the first scholar to apply public choice reasoning to the question why antitrust ...
Shughart, William F., II +1 more
openaire +2 more sources