Results 61 to 70 of about 2,254,914 (312)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Critica asupra modelarii economice si progresul stiintific

open access: yesPerspective Politice, 2015
In this paper I intend to bring some academic focus on the main criticisms of the methodology used by public choice theory. The purpose of this is aimed at discovering if the current methodological trend may be considered desirable from the point of view
Horia Andrei POPESCU
doaj  

THE INSTITUTIONS OF THE EUROPEAN UNION – AN ANALYTICAL APPROACH OF PUBLIC CHOICE THEORY AND INSTITUTIONAL ECONOMICS [PDF]

open access: yes
The paper is developing an analysis of the delegation of decisionmaking competencies towards different political levels of the multi-levelgovernance in the European Union.
Lars O. Pilz
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Remarks on network public theory

open access: yesManagerial Economics, 2014
This paper is a trial of capturing of a relation between traditional public sphere atrophy and the augmentation of a network public sphere. A thesis is advanced that the traditional public sphere is subject of the atrophy, however, the entire network ...
Marcin Brol, Sławomir Czetwertyński
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Review of Howard DeLong (1991), "A refutation of Arrow’s theorem", with a reaction, also on its relevance in 2008 for the European Union [PDF]

open access: yes
There will be many researchers who discover voting theory afresh and who will want to understand it and its interesting paradoxes. Arrow's theorem (1951, 1963) is the most celebrated result in social choice theory. It has been criticized a lot but Howard
Colignatus, Thomas
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Democracia vs. eficiência: a teoria da escolha pública Democracy and efficiency: the public choice theory

open access: yesLua Nova: Revista de Cultura e Política, 2001
Analisa-se o modo como a ênfase da teoria da escolha pública na eficiência gerencial mediante o desenvolvimento da organização burocrática entra em conflito com a dimensão política da vida social, sobretudo na sua vertente democrática.
André Borges
doaj   +1 more source

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